Results 141 to 150 of about 13,018 (313)
Theoretical backgrounds of durability analysis by normalized equivalent stress functionals
, 2003 Generalized durability diagrams and their properties are considered for a material under a multiaxial loading given by an arbitrary function of time. Material strength and durability under such loading are described in terms of durability, safety factor ...
Mikhailov, SE
core +1 more source
Advanced Science, EarlyView.This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li +7 more
wiley +1 more source
, 2012 The research carried out as part of this EngD is aimed at understanding the high temperature materials used in modern gas turbine applications and providing QinetiQ with the information required to assess component performance in new propulsion systems ...
Everitt, S., Everitt, Stewart
core
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Mechanical Engineering JournalThis study conducted a three-dimensional crack propagation simulation based on a nonlocal algorithm of P91 steel under fatigue and creep–fatigue loading. A damage-coupled inelastic constitutive model incorporating fatigue and creep damage parameters into
Akihiro MOTOKI, Masayuki ARAI
doaj +1 more source
The role of uncertainty in creep mechanics
, 2013 The development of constitutive models for the analysis of the creep (and fatigue) of structures at high temperature has a long history. Nevertheless, with a few exceptions, it is common in engineering practice to use relatively simple models, typically ...
Boyle, James
core
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, EarlyView.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Fatigue, Creep-Fatigue, and Thermomechanical Fatigue Life Testing of Alloys
, 2000 The fatigue crack initiation resistance of an alloy is determined by conducting a series of tests over a range of values of stress amplitude or strain range. The observed number of cycles to failure is plotted against the stress amplitude or strain range
McGaw, Michael A. +2 more
core
Advanced Science, Volume 13, Issue 36, 29 June 2026.We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong +8 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen +18 more
wiley +1 more source