Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models
Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis +11 more
wiley +1 more source
Effect of reinforcement type and viscoelasticity on static crack growth, fatigue, and creep resistance in acrylonitrile butadiene rubber (NBR) elastomers. [PDF]
Tavosi S +3 more
europepmc +1 more source
Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes +10 more
wiley +1 more source
A Variable-Order Fractional Derivative Approach-Defined Zener Model and Its Application in Predicting the Compressive Creep Strain of Bamboo Scrimber. [PDF]
Xiao W, Sun S, Gong X, Fu J.
europepmc +1 more source
Objective To develop, externally validate, and simplify a machine learning model to predict remission between 6 and 24 months in patients with rheumatoid arthritis (RA) initiating tumor necrosis factor inhibitors, JAK inhibitors, interleukin‐6 inhibitors, abatacept, or rituximab using data from 11 international registries in the JAK‐pot collaboration ...
Zubeyir Salis +22 more
wiley +1 more source
Evaluation of Aging Effects on Asphalt Binders and Pavements: Rheological Responses to Rejuvenators and Numerical Analysis of Polymer Modification. [PDF]
Karakas AS.
europepmc +1 more source
Objective The purpose of this study was to estimate the prevalence of difficult‐to‐manage (D2M) and treatment‐refractory (TR) axial spondyloarthritis (axSpA) and to identify factors associated with D2M and TR disease in a longitudinal cohort. Methods We performed a cross‐sectional analysis on data from the Schroeder Arthritis Institute Spondylitis ...
Patricia Remalante‐Rayco +8 more
wiley +1 more source
Nanomaterial Composite Compatibilized Rubber-Plastic Elastomer-Asphalt Interface Mechanism and Performance Evaluation. [PDF]
Xie T +5 more
europepmc +1 more source
Associating cognitive abilities with naturalistic search behavior
Abstract Differences in cognitive abilities affect search behaviors, but this has mostly been observed in laboratory experiments. There is limited research on how users search for information in real‐world, naturalistic settings and how real‐world search behaviors relate to cognitive abilities.
Tung Vuong +2 more
wiley +1 more source
Multi-Dimensional Performance Evaluation and Basalt Fiber Strengthening Effect of Secondary Hot In-Place Recycled Asphalt Mixtures. [PDF]
Su B, Hu J, Kang A, Zhang Y.
europepmc +1 more source

