Results 41 to 50 of about 2,870 (248)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Desempenho de cordeiros sob quatro sistemas de produção Performance of lambs under four production systems

Revista Brasileira de Zootecnia, 2005
Quarenta cordeiros mestiços "Texel" oriundos de partos simples foram distribuídos em quatro tratamentos, para se comparar o desempenho dos animais terminados a pasto, com e sem suplementação, e em confinamento.
José Reinaldo de Amorim Bernardi, João Batista Alves, Camila Motta Marin   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Effects of lactation feed intake and creep feeding on sow and piglet performance1

Journal of Animal Science, 2010
A total of 84 sows (PIC Line 1050) were blocked according to day of farrowing and parity and allotted in a 2 x 2 factorial arrangement of treatments with lactation feed intake (ad libitum vs. restricted) and creep feeding (no vs. yes) as factors. Sows fed for ad libitum intake (ad libitum-fed) were allowed free access to a common lactation diet (3,503 ...
R. C. Sulabo, J. Y. Jacela, M. D. Tokach, S. S. Dritz, R. D. Goodband, J. M. DeRouchey, J. L. Nelssen   +6 more
  +6 more sources

Risk factors for non-adapting weaner lambs entering South African feedlots

South African Journal of Animal Science
A growing concern in South African feedlot systems is the increased prevalence of non-adapting weaner lambs. This study aimed to identify on-farm risk factors associated with poor adaptation using retrospective production data and a structured ...
Jarred Morris, Geoffrey Fosgate, Lieza Odendaal, Edward Webb, Sarah Clift   +4 more
doaj   +1 more source

Efeito do creep feeding sobre o desempenho de bezerros e a eficiência reprodutiva de primíparas Nelore, em pastejo Effect of creep feeding on average daily gain and weaning weight of calves and on reproductive efficiency of primiparous Nelore cows under grazing

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2006
Avaliou-se o efeito da suplementação de bezerros em sistema de creep feeding, em pastagens de Brachiaria brizantha, durante o período de amamentação, sobre o ganho médio diário (GMD), peso à desmama (PD) e taxa de gestação, em delineamento inteiramente ...
E. Nogueira, M.G. Morais, V.J. Andrade, E.D.S. Rocha, A.S. Silva, A.T. Brito   +5 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source