Results 61 to 70 of about 37,908 (346)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Ecological study of aquatic midges and some related insects with special reference to feeding habits [PDF]
, 1922 Die Schweiz ist ein reiches Land. Sie verfügt über viele Millionäre. Der große Reichtum konzentriert sich auf wenige Familien und Personen. In der Schweiz leben aber auch eine halbe Million der Bevölkerung (7,5 Mio.) in Haushalten von Erwerbstätigen, die
A. Diezinger +19 more
core +2 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Acta Scientiarum: Animal Sciences, 2009 O objetivo deste estudo foi avaliar o comportamento ingestivo de cordeiros em pastagem de Tifton-85 (Cynodon spp.) em três sistemas de produção: cordeiros desmamados aos 60 dias de idade e mantidos em pastagem; cordeiros mantidos com suas mães em ...
César Henrique Espírito Candal Poli +5 more
doaj +1 more source
Machining accuracy in creep feed grinding.
Journal of the Japan Society of Precision Engineering, 1985 This paper aims to clarify comprehensively and quantitatively the effects of elastic deflection between wheel and workpiece, wheel wear and thermal deformation of workpiece on the profile and dimensional errors of workpiece which is produced in one pass creep feed grinding.
Susumu OHISHI, Yuji FURUKAWA, Osamu SUGA
openaire +2 more sources
Kansas Agricultural Experiment Station Research Reports, 2007 A total of 54 sows (PIC Line 1050) and their litters were used in this study to determine the effects of varying durations of creep feeding on the rate of pigs consuming creep feed (eaters) and pre-weaning performance. Two groups of sows were blocked according to parity and date of farrowing and allotted to three experimental treatments using a ...
R C Sulabo +7 more
openaire +2 more sources
Knowledge synthesis: Animal health and welfare in organic pig production - Final Report COREPIG [PDF]
, 2011 This report reviews the available information on the welfare of pigs when maintained according to organic standards in Europe. It begins by overviewing the populations of organic pigs in different countries at the time of writing (2007), the organic ...
Bochicchio, David +17 more
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