Results 41 to 50 of about 23,863,179 (302)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Viscoelastic plastic creep constitutive model based on energy conservation law and strain energy theory

Scientific Reports
On the basis of the law of conservation of energy, the three stages of rock creep are analyzed. The reasons for the difficulty in studying the accelerated creep stage of rocks using the traditional creep model are expounded.
Di Zhou, Xiangjin Tian, Shuguang Zhang, Wang Zeng, Minye Zhang, Yanchao Feng, Wenbo Liu, Xiang Huang, Mingzhuo Fan, Ye Sun   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Creep constitutive model of strain energy density considering the whole process of creep deformation.

PLoS ONE
Aiming at the problem that the traditional creep model is difficult to reflect the characteristics of accelerated creep stage of rock, the influence of stress state on accelerated creep is fully considered, and a constitutive model which can describe ...
Yuemei Li
doaj   +1 more source

Study on symmetric creep model based on creep curves and parametric sensitivity analysis

Meitan kexue jishu
In order to obtain the creep characteristics of the surrounding rock of the Dianzhong water diversion tunnel and to study the long-term stability of the surrounding rock of the tunnel, a fully automated triaxial developed by Wuhan Institute of ...
Wenbo LIU, Shuguang ZHANG, Xiang HUANG, Yipin LIU   +3 more
doaj   +1 more source

Study on the Allowable Exposure Time of Temporary Goaf in the Open Stope and Backfill Mining Method with Large Structure Parameters

Advances in Civil Engineering, 2020
Based on the uniaxial rheological experiment data of iron ore rock mass and filling body in large-scale stope obtained by using the rock servo controlling creep equipment, the characteristics of the creep curve were analyzed. The creep models of iron ore
Xiaosheng Liu, Weijun Wang, Yizhong Luo, Jin Zhan   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Creep Behavior of Saturated Clay in Triaxial Test and a Hyperbolic Model

Geofluids, 2021
As one of the basic mechanical properties of soil, the creep property of a given type soil is related to stress path, and stress level. In this paper, triaxial shear creep tests under different deviatoric stress levels were performed on both intact ...
Bin Xiao, Minyun Hu, Peijiao Zhou, Yuke Lu, Yong Zhang   +4 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source