Results 61 to 70 of about 20,345 (260)

Analysis of Shear Characteristics of Deep, Anchored Rock Mass under Creep Fatigue Loading

open access: yesAdvances in Civil Engineering, 2021
To study the influence of earthquakes and engineering disturbances on the deformation of deeply buried rock masses, shear tests were carried out on anchored sandstone rock masses, anchored marble rock masses, and anchored granite rock masses under creep ...
Xiaofeng Li, Zhixiang Yin
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Creep Behavior of Saturated Clay in Triaxial Test and a Hyperbolic Model

open access: yesGeofluids, 2021
As one of the basic mechanical properties of soil, the creep property of a given type soil is related to stress path, and stress level. In this paper, triaxial shear creep tests under different deviatoric stress levels were performed on both intact ...
Bin Xiao   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Nonlinear Viscoelastic-Plastic Creep Model of Rock Based on Fractional Calculus

open access: yesAdvances in Civil Engineering, 2022
A rock creep constitutive model is the core content of rock rheological mechanics theory and is of great significance for studying the long-term stability of engineering.
Erjian Wei   +6 more
doaj   +1 more source

A New Model of Nonlinear Dynamic Creep [PDF]

open access: yes, 1995
The creep of structures is a nonlinear mathematical problem and the adequate simulation of creep processes involves several difficulties. In order to overcome them, computer numerical methods involving three simulation steps which are all equally important have been used: accurate simulation of the kinematic (possibly nonlinear) and the quasi static ...
Breslavsky, D., Morachkovsky, O.
openaire   +2 more sources

Creep motion of a model frictional system [PDF]

open access: yesPhysical Review E, 2011
We report on the dynamics of a model frictional system submitted to minute external perturbations. The system consists of a chain of sliders connected through elastic springs that rest on an incline. By introducing cyclic expansions and contractions of the springs we observe a reptation of the chain.
Blanc, Baptiste   +2 more
openaire   +6 more sources

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