Results 51 to 60 of about 161,193 (307)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Experimental study on the shear creep behavior of residual soil with varying rock content.

PLoS ONE
Using residual soil from the Shanghecun landslide in the western Henan Province, shear creep tests of residual soil samples with different rock contents (RCs) were performed to explore the creep characteristics, creep rate, and long-term strength of the ...
Chuang Wang, Jinyu Dong, Shengwen Qi, Jiancang Zhao, Lei Xue, Dengpo Fan   +5 more
doaj   +1 more source

Microstructure and Hardness Effects on Behavior of Copper Alloy under Creep – Fatigue Interaction [PDF]

Engineering and Technology Journal, 2011
The microstructure and hardness of copper alloy after fatigue-creep interaction testing have been investigated. Experiments were carried out in the temperature range from room temperature to 300oC.
Mairb R. Abdul Hassan
doaj   +1 more source

Spatial fluctuations in transient creep deformation

, 2011
We study the spatial fluctuations of transient creep deformation of materials as a function of time, both by Digital Image Correlation (DIC) measurements of paper samples and by numerical simulations of a crystal plasticity or discrete dislocation ...
Alava M J, Amandine Miksic, Barrat J L, Berthier L, Coffin D W, Csikor F F, Dauchot O, Jari Rosti, Juha Koivisto, Lasse Laurson, Louchet F, Mikko J Alava, Monkman F C, Mustalahti M, Nabarro F R N, Pertsinidis A, Salminen L I, Van der Giessen E, Zaiser M   +18 more
core   +1 more source

Tensile Creep of High-Strength Concrete

Journal of Advanced Concrete Technology, 2006
Tensile creep tests on high-strength concrete have been performed. Besides up-to-date creep data which have been generated a new phenomenon has been discovered, i. e. shrinkage of loaded specimens is larger than of non-loaded ones. It seems that this phenomenon is in agreement with Powers' creep theory.
Hans-Wolf Reinhardt, Tassilo Rinder
openaire   +2 more sources

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A creep model for metallic composites based on matrix testing: Application to Kanthal composites [PDF]

An anisotropic creep model is formulated for metallic composites with strong fibers and low to moderate fiber volume percent (less than 40 percent).
Arnold, S. M., Bartolotta, Paul A., Binienda, W. K., Robinson, D. N.   +3 more
core   +1 more source