Results 31 to 40 of about 15,715 (261)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Creep and mechanical behavior after sustained loading of red mud-slag based geopolymer concrete at early-age

Case Studies in Construction Materials
To investigate the effects of stress levels, silica fume contents, fiber types, and fiber contents on the drying shrinkage, creep, and mechanical properties of early-age Red mud-Slag based GeoPolymer Concrete (RS-GPC), a comprehensive series of ...
Xiaolei Zhang, Yongbao Wang, Jianglong Han, Xu Li   +3 more
doaj   +1 more source

Large-scale field creep tests on moraine soil

Yantu gongcheng xuebao, 2023
The sediment of the Kangding Bank of Xingkkang Bridge of Sichuan-Tibet Expressway is mostly consisted of very thick moraine soil. In order to study the creep characteristics of the moraine soil, the large-scale field creep tests in meters are carried out
GUO Xifeng , WANG Zhonghao
doaj   +1 more source

Relationship between the Torsion or Bending Creep Strength and the Tension Creep Strength of 13%Cr Steel

Journal of the Society of Materials Science, Japan, 1966
In order to find the correlation of the torsion or bending creep strength with the tensile creep strength for hardened and tempered 13%Cr steel, creep tests in tension, torsion and pure bending have been made at temperatures 400°C and 500°C. And then, these experimental results were compared with the analytical results by calculation based on von Mises
UEDA, Taro, MATSUO, Tetsuo
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Catalog of NIMS creep data sheets

Science and Technology of Advanced Materials, 2019
The background of the NIMS Creep Data Sheet Project, together with the preliminary study and facilities, material selection, and testing method, is summarized.
Kota Sawada, Kazuhiro Kimura, Fujio Abe, Yasushi Taniuchi, Kaoru Sekido, Takehiro Nojima, Toshio Ohba, Hideaki Kushima, Hideko Miyazaki, Hiromichi Hongo, Takashi Watanabe   +10 more
doaj   +1 more source

Evaluation equation for creep rupture life of Gr. 91 steel considering region classification and difference in creep strength between heats

Nihon Kikai Gakkai ronbunshu, 2022
A creep rupture life evaluation equation for Gr. 91 steel was proposed, taking account of the region classification and the creep strength difference between heats. The creep rupture life evaluation equation consists of three parts.
Kenichi KIZU
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Experimental study of creep properties of silty mudstone under triaxial compression

工程科学与技术, 2012
:In order to reveal the creep properties of silty mudstone in Badong Formation strata in the Three Gorges area, the creep test of saturated silty mudstone under triaxial compression was carried out on the RLJW-2000 rock microcomputer-controlled rheology ...
Li ya-li
doaj