Results 41 to 50 of about 1,903 (188)

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, EarlyView.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur, Jashvant D. Unadkat, Emily E. Fay, Nina Isoherranen, Mary F. Hebert   +4 more
wiley   +1 more source

Enantiospecific Acid‐Catalysed Hydroperoxidation of Scalemic Tertiary Benzylic Alcohols Facilitating a Concise Asymmetric Synthesis of Yingzhaosu C

European Journal of Organic Chemistry, EarlyView.
Asymmetric synthesis of antimalarial yingzhaosu C was achieved in 4–5 steps by asymmetric Grignard synthesis of (R)‐gossonorol followed by novel enantiospecific hydroperoxidation. We report a concise asymmetric synthesis of antimalarial yingzhaosu C in 59% ee.
Saranna E. Kavanagh, Claudio Monasterolo, Declan G. Gilheany   +2 more
wiley   +1 more source

Imidazole-rich copper peptides as catalysts in xenobiotic degradation.

PLoS ONE, 2020
Laccases, oxidative copper-enzymes found in fungi and bacteria were used as the basis in the design of nona- and tetrapeptides. Laccases are known to be excellent catalysts for the degradation of phenolic xenobiotic waste.
Sharifa Zaithun Begum, Nurul Shairah Mohd Nizam, Azira Muhamad, Mohd Izham Saiman, Karen Anne Crouse, Mohd Basyaruddin Abdul Rahman   +5 more
doaj   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

Food Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao, Jiayao Wang, Yilian Huang, Na Zhang, Xiaodan Shi, Zongcai Tu, Zuohua Xie, Tao Yuan, Hongmei Yin   +8 more
wiley   +1 more source

Odorants in Fish Feeds: A Potential Source of Malodors in Aquaculture

Frontiers in Chemistry, 2018
Although the microbiota is considered to be the primary source of off-flavors in farmed fish, there is a lack of information about the possible contribution of feeds to fish malodor.
Mohamed A. A. Mahmoud, Mohamed A. A. Mahmoud, Mohamed A. A. Mahmoud, Thorsten Tybussek, Helene M. Loos, Helene M. Loos, Maria Wagenstaller, Andrea Buettner, Andrea Buettner   +8 more
doaj   +1 more source

Thermal Degradation and Thermal Decomposition of Plasticized PVC Including POSS Additives for PVC Compounds: Mechanisms, Impact, and Performance of Standards

Journal of Vinyl and Additive Technology, EarlyView.
Additives' structures. ABSTRACT Poly(vinyl chloride) has been a key polymeric material since its commercial production in 1931, demonstrating versatility across numerous industries due to its compatibility with various additives. PVC's inherent properties, flame retardance, durability, and recyclability make it ideal for building and construction ...
Stefano Gardi, Gianluca Sarti, Luca Palin, Enrico Boccaleri, Alberto Frache   +4 more
wiley   +1 more source

Hypersensitivity to Excipients in Drugs: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Drugs contain active pharmaceutical ingredients and excipients, compounds which enhance the pharmacokinetics, stability and palatability of the pharmaceutical formulation. While most drug hypersensitivity reactions (DHR) are caused by active ingredients, excipients may also be involved.
Lene H. Garvey, Knut Brockow, Annick Barbaud, Charlotte G. Mortz, Gianfranco Calogiuri, Asli Gelincik, Osman O. Yeğit, Alla Nakonechna, Annette Wagner, Rik Schrijvers, Toon Ieven   +10 more
wiley   +1 more source

Role of adjunctive methacryloyloxydecyl dihydrogen phosphate primers on dentin bond strength of universal adhesives under saliva and artificial aging

European Journal of Oral Sciences, EarlyView.
Abstract This study evaluated whether adjunctive 10‐methacryloyloxydecyl dihydrogen phosphate (MDP) primers enhance the microtensile bond strength (µTBS) of two universal adhesives (UAs) to dentin under artificial aging and repeated salivary contamination applied at each bonding step.
Marjorie Zanini, Amélie Mainjot, Stéphane Le Goff, Jean‐François Nguyen   +3 more
wiley   +1 more source