Results 11 to 20 of about 35,863 (248)

Peripheral Signatures of Multidimensional Pathology in Symptomatic and Asymptomatic Creutzfeldt-Jakob Disease. [PDF]

CNS Neurosci Ther
Plasma biomarkers in CJD reveal multisystem involvement, with neuronal injury markers showing strong discriminative performance and vascular proteins indicating blood–brain barrier dysfunction. In asymptomatic PRNP mutation carriers, biomarker changes are minimal and emerge mainly near disease onset ABSTRACT Background Plasma markers of neuronal injury
Chen ZY, Chu M, Wang YH, Liu R, Zhang J, Yue AL, Lu H, He QQ, Hou JH, Chen YF, Ye H, Wu LY.   +11 more
europepmc   +2 more sources

Creutzfeldt-Jakob disease [PDF]

Journal of Clinical Pathology, 1972
This label is applied to a group of patients whose neurological and psychiatric symptoms are somewhat varied and whose brains show pathological changes which are basically similar, although their distribution and extent in the nervous system may vary (Siedler and Malamud, 1963). In the early 19203 A.
L J, Burger, A J, Rowan, E S, Goldensohn
openaire   +5 more sources

The First Sporadic Creutzfeldt–Jakob Disease Case with a Rare Molecular Subtype VV1 and 1-Octapeptide Repeat Deletion in PRNP

Viruses, 2021
In the present manuscript, we report the clinical presentation and challenging diagnostic work-up of a sporadic Creutzfeldt–Jakob disease patient with confirmed VV1 subtype and heterozygous 1-octapeptide repeat deletion in the prion protein gene.
Aušrinė Areškevičiūtė, Eva Løbner Lund, Sabina Capellari, Piero Parchi, Christian Tersbøl Pinkowsky   +4 more
doaj   +1 more source

Characterization of Prion Disease Associated with a Two-Octapeptide Repeat Insertion

Viruses, 2021
Genetic prion disease accounts for 10–15% of prion disease. While insertion of four or more octapeptide repeats are clearly pathogenic, smaller repeat insertions have an unclear pathogenicity.
Nicholas Brennecke, Ignazio Cali, Tze How Mok, Helen Speedy, Genomics England Research Consortium, Laszlo L. P. Hosszu, Christiane Stehmann, Laura Cracco, Gianfranco Puoti, Thomas W. Prior, Mark L. Cohen, Steven J. Collins, Simon Mead, Brian S. Appleby   +13 more
doaj   +1 more source

Creutzfeldt–Jakob disease [PDF]

Psychogeriatrics, 2011
AbstractCreutzfeldt–Jakob disease (CJD) is a progressive, degenerative, and fatal disease of the central nervous system. It is caused by abnormal accumulation of prion proteins and is characterized mainly by progressive dementia, myoclonus, and cerebellar, pyramidal, and extrapyramidal findings. Psychiatric symptoms may also accompany CJD and are often
Ali Görkem, Gençer, Zerrin, Pelin, Cem İsmail, Küçükali, Ozgür Bilgin, Topçuoğlu, Nuriye, Yilmaz   +4 more
openaire   +2 more sources

Variant Creutzfeldt–Jakob disease [PDF]

Haemophilia, 2003
Summary.  Variant Creutzfeldt–Jakob disease (CJD) is an emerging form of human prion disease caused by oral exposure to the bovine spongiform encephalopathy agent. Most cases have occurred in the UK, but smaller numbers of cases have been identified in 10 other countries worldwide.
H J T, Ward, M W, Head, R G, Will, J W, Ironside   +3 more
openaire   +5 more sources

Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease [PDF]

, 2013
Blood transfusion has been identified as a source of human-to-human transmission of variant Creutzfeldt–Jakob disease. Three cases of variant Creutzfeldt–Jakob disease have been identified following red cell transfusions from donors who subsequently ...
Abigail B. Diack, Bishop, Brown, Bruce, Bruce, Bruce, Clarke, Diack, Diane L. Ritchie, Fraser, Garske, Head, Hill, Hilton, HPA, James W. Ironside, Jean C. Manson, Llewelyn, Matthew T. Bishop, Peden, Pocchiari, Prusiner, Ritchie, Robert G. Will, Wadsworth, Will, Wroe   +26 more
core   +1 more source

Creutzfeldt-Jakob Disease Mimicking Wernicke Encephalopathy [PDF]

Journal of Neurocritical Care, 2015
Background: Creutzfeldt-Jakob disease (CJD) is the prototype of a family of rare and fatal human degenerative conditions characterized by rapidly progressive dementia, myoclonus and akinetic mutism.
Min Suck Kim, Sung Je Kim, Youngrok Do
doaj   +1 more source

Detection of Type 1 Prion Protein in Variant Creutzfeldt-Jakob Disease [PDF]

, 2006
Molecular typing of the abnormal form of the prion protein (PrP(Sc)) has come to be regarded as a powerful tool in the investigation of the prion diseases.
Bruce, Moira E., Head, Mark W., Ironside, James W., Langeveld, Jan P.m., Ritchie, Diane L., Van Zijderveld, Fred G., Yull, Helen M.   +6 more
core   +2 more sources

Etymologia: Creutzfeldt-Jakob Disease

Emerging Infectious Diseases, 2017
Ronnie Henry, Frederick A. Murphy
doaj   +5 more sources