Bioassay studies support the potential for iatrogenic transmission of variant Creutzfeldt Jakob Disease through dental procedures [PDF]
, 2012 <p>Background: Evidence is required to quantify the potential risks of transmission of variant Creutzfeldt Jakob (vCJD) through dental procedures. Studies, using animal models relevant to vCJD, were performed to address two questions.
Elizabeth Kirby (115076) +54 more
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Creutzfeldt-Jakob disease: literature review based on three case reports
, 2022 . Creutzfeldt-Jakob disease (CJD) is one of the transmissible spongiform encephalopathies that lead to rapidly progressive dementia. CJD has a low prevalence, and the average survival is only 1 year after the onset of symptoms.
Mateus Aragão Esmeraldo (10351394) +3 more
core +3 more sources
No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease
Emerging Infectious Diseases, 2020 We investigated a clinical case of variant Creutzfeldt-Jakob Disease in a person heterozygous for methionine/valine at codon 129 of the prion protein gene and identified the same strain properties in variant Creutzfeldt-Jakob disease in methionine ...
Aileen Boyle +6 more
doaj +1 more source
CSF concentrations of cAMP and cGMP are lower in patients with Creutzfeldt-Jakob disease but not Parkinson's disease and amyotrophic lateral sclerosis. [PDF]
, 2012 The cyclic nucleotides cyclic adenosine-3',5'-monophosphate (cAMP) and cyclic guanosine-3',5'-monophosphate (cGMP) are important second messengers and are potential biomarkers for Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and ...
Oeckl, Patrick +23 more
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Evidence for a pathogenic role of different mutations at codon 188 of PRNP [PDF]
, 2008 Clinical and pathological changes in familial Creutzfeldt-Jakob disease (CJD) cases may be similar or indistinguishable from sporadic CJD. Therefore determination of novel mutations in PRNP remains of major importance.
Eva-Maria Grasbon-Frodl +49 more
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Creutzfeldt-Jakob Disease Presenting as Nonconvulsive Status Epilepticus
Case Reports in Neurological Medicine, 2018 Creutzfeldt-Jakob disease is a rare, rapidly progressive spongiform encephalopathy in humans. EEG plays an important role in diagnosing this disease. In some patients, epileptic activity and encephalopathy from various aetiologies may share morphological
Aleksei Rakitin +5 more
doaj +1 more source
Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease
Emerging Infectious Diseases, 2014 We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease.
Jean Yves Douet +11 more
doaj +1 more source
Frontiers in Neurology, 2023 The most frequently utilized biomarkers to support a pre-mortem clinical diagnosis of sporadic Creutzfeldt–Jakob disease (sCJD) include concentrations of the 14-3-3 and total tau (T-tau) proteins, as well as the application of protein amplification ...
Matteo Senesi +18 more
doaj +1 more source
Creutzfeldt-Jakob disease [PDF]
Journal of Clinical Pathology, 1972 This label is applied to a group of patients whose neurological and psychiatric symptoms are somewhat varied and whose brains show pathological changes which are basically similar, although their distribution and extent in the nervous system may vary (Siedler and Malamud, 1963). In the early 19203 A.
openaire +3 more sources
Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]
, 2010 Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Meissner, Bettina +19 more
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