Results 1 to 10 of about 37,766 (292)

Prions Ex Vivo: What Cell Culture Models Tell Us about Infectious Proteins

International Journal of Cell Biology, 2013
Prions are unconventional infectious agents that are composed of misfolded aggregated prion protein. Prions replicate their conformation by template-assisted conversion of the endogenous prion protein PrP.
Sybille Krauss, Ina Vorberg
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Are amyloids infectious? Prions and prion-like proteins: myths and facts [PDF]

, 2018
Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders affecting mammals. Albeit their low incidence in humans, prion diseases are a subject of passionate research due to their unorthodox ...
Morales Loyola, Rodrigo
core  

Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease

Journal of Nanobiotechnology, 2023
Evidence suggests that increased level/aggregation of β-amyloid (Aβ) peptide, together with enhanced phosphorylation/aggregation of tau protein, play a critical role in the development of Alzheimer’s disease (AD), the leading cause of dementia in the ...
Karthivashan Govindarajan, Satyabrata Kar   +1 more
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Spatial Sequestration and Oligomer Remodeling During \u3cem\u3ede novo\u3c/em\u3e [\u3cem\u3ePSI\u3c/em\u3e\u3csup\u3e+\u3c/sup\u3e] Formation [PDF]

, 2017
Prions are misfolded, aggregated, infectious proteins found in a range of organisms from mammals to bacteria. In mammals, prion formation is difficult to study because misfolding and aggregation take place prior to symptom presentation.
Lyke, Douglas, Manogaran, Anita L.
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On the statistical mechanics of prion diseases

, 2001
We simulate a two-dimensional, lattice based, protein-level statistical mechanical model for prion diseases (e.g., Mad Cow disease) with concommitant prion protein misfolding and aggregation.
A. Coghlan, A. Slepoy, C. I. Lasmézas, D. J. Stekel, D. L. Cox, D. O. V. Alonso, F. Pázmándi, H. Rudyk, J. H. Come, J. Masel, J. N. Onuchic, J. S. Griffith, K. Post, M. A. Nowak, M. Beekes, M. Eigen, M. Horiuchi, M. Horiuchi, M. Laurent, R. Demaimay, R. M. Anderson, R. R. P. Singh, R. V. Kulkarni, S. B. Prusiner, T. R. Serio, W. Swietnicki   +25 more
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Synthesis and structural characterization of a mimetic membrane-anchored prion protein [PDF]

, 2006
During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but
Andrew C. Gill, Ansari AA, Atvinder K. Rullay, Bertozzi CR, Blanch EW, Borchelt D, Caughey B, Caughey B, Caughey B, Caughey BW, Critchley P, David H. Crout, Eberl H, Ferris A, Georges C, Gill AC, Govaerts C, Haire LF, Harris DA, Hornemann S, Ian D. Sylvester, Imanpreet K. Bath, Kazlauskaite J, Kazlauskaite J, Kenyon GL, King SA, Kirby L, Klein TR, Kocienski PJ, Legname G, Matthew R. Hicks, Mui B, Nosjean O, Pan KM, Poss AJ, Safar J, Seddon AM, Shyng SL, Stahl N, Stahl N, Teresa J. T. Pinheiro, Whitesell JK, Wuthrich K, Zahn R, Zhang ZY   +44 more
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Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system

Scientific Reports
Prion diseases are fatal transmissible neurodegenerative diseases that affect many mammals, including humans, caused by the templated misfolding of the prion protein.
Hailey Pineau, Valerie L. Sim
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Improving the Predictive Value of Prion Inactivation Validation Methods to Minimize the Risks of Iatrogenic Transmission With Medical Instruments

Frontiers in Bioengineering and Biotechnology, 2020
Prions are pathogenic infectious agents responsible for fatal, incurable neurodegenerative diseases in animals and humans. Prions are composed exclusively of an aggregated and misfolded form (PrPSc) of the cellular prion protein (PrPC).
Mohammed Moudjou, Johan Castille, Bruno Passet, Laetitia Herzog, Fabienne Reine, Jean-Luc Vilotte, Human Rezaei, Vincent Béringue, Angélique Igel-Egalon, Angélique Igel-Egalon   +9 more
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The Way forward for the Origin of Life: Prions and Prion-Like Molecules First Hypothesis

Life, 2021
In this paper the hypothesis that prions and prion-like molecules could have initiated the chemical evolutionary process which led to the eventual emergence of life is reappraised.
Sohan Jheeta, Elias Chatzitheodoridis, Kevin Devine, Janice Block   +3 more
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Aerosols transmit prions to immunocompetent and immunodeficient mice. [PDF]

PLoS Pathogens, 2011
Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not generally considered to be airborne.
Johannes Haybaeck, Mathias Heikenwalder, Britta Klevenz, Petra Schwarz, Ilan Margalith, Claire Bridel, Kirsten Mertz, Elizabeta Zirdum, Benjamin Petsch, Thomas J Fuchs, Lothar Stitz, Adriano Aguzzi   +11 more
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