Results 11 to 20 of about 14,426 (178)

Resistance of Bovine Spongiform Encephalopathy (BSE) Prions to Inactivation [PDF]

PLoS Pathogens, 2008
Distinct prion strains often exhibit different incubation periods and patterns of neuropathological lesions. Strain characteristics are generally retained upon intraspecies transmission, but may change on transmission to another species.
David V Glidden, Stanley B. Prusiner, Kurt Giles   +2 more
exaly   +2 more sources

Protease-Sensitive Synthetic Prions [PDF]

PLoS Pathogens, 2010
Prions arise when the cellular prion protein (PrP(C)) undergoes a self-propagating conformational change; the resulting infectious conformer is designated PrP(Sc).
David W Colby, Giuseppe Legname, Stanley B. Prusiner   +2 more
exaly   +2 more sources

Artificial strain of human prions created in vitro

Nature Communications, 2018
Synthetic prions have previously been generated from recombinant rodent PrP. Here the authors generate synthetic human prions, by seeding human PrP with CJD prions, and characterize its infectivity in mice.
Witold Surewicz, Vytautas Smirnovas, Nicholas R Maurer   +2 more
exaly   +2 more sources

Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

BMC Biology, 2021
Background The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau folding pathways that ...
Sang-Gyun Kang, Zhuang Zhuang Han, Nathalie Daude, Emily McNamara, Serene Wohlgemuth, Laura Molina-Porcel, Jiri G. Safar, Sue-Ann Mok, David Westaway   +8 more
doaj   +1 more source

Innate Immune Status of Glia Modulates Prion Propagation in Early Stage of Infection

Cells, 2023
Prion diseases are progressive neurodegenerative disorders affecting humans and various mammals. The prominent neuropathological change in prion-affected brains is neuroinflammation, histopathologically characterized by reactive gliosis surrounding prion
Sang-Gyun Kang, Chiye Kim, Judd Aiken, Debbie McKenzie   +3 more
doaj   +1 more source

Susceptibility of Beavers to Chronic Wasting Disease

Biology, 2022
Chronic wasting disease (CWD) is a contagious, fatal, neurodegenerative prion disease of cervids. The expanding geographical range and rising prevalence of CWD are increasing the risk of pathogen transfer and spillover of CWD to non-cervid sympatric ...
Allen Herbst, Serene Wohlgemuth, Jing Yang, Andrew R. Castle, Diana Martinez Moreno, Alicia Otero, Judd M. Aiken, David Westaway, Debbie McKenzie   +8 more
doaj   +1 more source

Unconjugated PLGA nanoparticles attenuate temperature-dependent β-amyloid aggregation and protect neurons against toxicity: implications for Alzheimer’s disease pathology

Journal of Nanobiotechnology, 2022
Conversion of β-amyloid (Aβ) peptides from soluble random-coil to aggregated protein enriched with β-sheet-rich intermediates has been suggested to play a role in the degeneration of neurons and development of Alzheimer’s disease (AD) pathology ...
Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Mariana Kulka, Satyabrata Kar   +7 more
doaj   +1 more source

Prion-Like Propagation Mechanisms in Tauopathies and Traumatic Brain Injury: Challenges and Prospects

Biomolecules, 2020
The accumulation of tau protein in the form of filamentous aggregates is a hallmark of many neurodegenerative diseases such as Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE).
Hadeel Alyenbaawi, W. Ted Allison, Sue-Ann Mok   +2 more
doaj   +1 more source

RETRACTED ARTICLE: Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells

Scientific Reports, 2021
Misfolding of the cellular prion protein, PrPC, into the amyloidogenic isoform, PrPSc, which forms infectious protein aggregates, the so-called prions, is a key pathogenic event in prion diseases.
Hideyuki Hara, Junji Chida, Keiji Uchiyama, Agriani Dini Pasiana, Etsuhisa Takahashi, Hiroshi Kido, Suehiro Sakaguchi   +6 more
doaj   +1 more source

Reduction of Chronic Wasting Disease Prion Seeding Activity following Digestion by Mountain Lions

mSphere, 2021
Chronic wasting disease (CWD) is a transmissible prion disease first observed in the 1960s in North America. This invariably fatal disease affects multiple cervid species in the wild and in captivity.
Chase Baune, Lisa L. Wolfe, Kristen C. Schott, Karen A. Griffin, Andrew G. Hughson, Michael W. Miller, Brent Race   +6 more
doaj   +1 more source