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New implications for prion diseases therapy and prophylaxis [PDF]
Frontiers in Molecular NeurosciencePrion diseases are rare, fatal, progressive neurodegenerative disorders that affect both animal and human. Human prion diseases mainly present as Creutzfeldt-Jakob disease (CJD).
Fangzhou Liu, Wenqi Lü, Ling Liu
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Potential Therapeutic Use of Stem Cells for Prion Diseases [PDF]
Cells, 2023 Prion diseases are neurodegenerative disorders that are progressive, incurable, and deadly. The prion consists of PrPSc, the misfolded pathogenic isoform of the cellular prion protein (PrPC).
Mohammed Zayed +2 more
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Genetic aspects of human prion diseases [PDF]
Frontiers in Neurology, 2022 Human prion diseases are rapidly progressive and fatal neurodegenerative conditions caused by a disease-causing isoform of the native prion protein. The prion protein gene (PRNP) encodes for the cellular prion protein, which is the biological substrate ...
Brian S. Appleby +4 more
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Identification of an altered gut microbiome and the protective effect of microbiome changer in prion diseases [PDF]
Veterinary ResearchPrion diseases are fatal and contagious brain disorders caused by a pathogenic prion protein (PrPSc) derived from the benign prion protein (PrPC). To date, there are no therapeutic substances to completely block prion diseases. Thus, the development of a
Yong-Chan Kim +2 more
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Loss of Homeostatic Microglia Signature in Prion Diseases [PDF]
Cells, 2022 Prion diseases are neurodegenerative diseases that affect humans and animals. They are always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology is the misfolding of an endogenous protein, the cellular prion protein ...
Yue Wang +7 more
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Human prion diseases and the prion protein – what is the current state of knowledge? [PDF]
Translational Neuroscience, 2023 Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge.
Nafe Reinhold +2 more
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Scientific Reports, 2022 Transgenic mice over-expressing human PRNP or murine Prnp transgenes on a mouse prion protein knockout background have made key contributions to the understanding of human prion diseases and have provided the basis for many of the fundamental advances in
Graham S. Jackson +5 more
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Scientific Reports, 2021 The cerebrospinal fluid (CSF) real-time quaking-induced conversion assay (RT-QuIC) is an ultrasensitive prion amyloid seeding assay for diagnosis of sporadic Creutzfeldt–Jakob disease (CJD) but several prion strains remain unexplored or resistant to ...
Tze How Mok +7 more
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Scientific Reports, 2022 There is an urgent need to develop disease-modifying therapies to treat neurodegenerative diseases which pose increasing challenges to global healthcare systems.
Madeleine Reilly +7 more
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Prion protein gene mutation detection using long-read Nanopore sequencing
Scientific Reports, 2022 Prion diseases are fatal neurodegenerative conditions that affect humans and animals. Rapid and accurate sequencing of the prion gene PRNP is paramount to human prion disease diagnosis and for animal surveillance programmes.
François Kroll +6 more
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