Results 11 to 20 of about 2,165,687 (231)
Genetic aspects of human prion diseases [PDF]
Frontiers in Neurology, 2022 Human prion diseases are rapidly progressive and fatal neurodegenerative conditions caused by a disease-causing isoform of the native prion protein. The prion protein gene (PRNP) encodes for the cellular prion protein, which is the biological substrate ...
Brian S. Appleby +4 more
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Potential Therapeutic Use of Stem Cells for Prion Diseases [PDF]
Cells, 2023 Prion diseases are neurodegenerative disorders that are progressive, incurable, and deadly. The prion consists of PrPSc, the misfolded pathogenic isoform of the cellular prion protein (PrPC).
Mohammed Zayed +2 more
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Identification of an altered gut microbiome and the protective effect of microbiome changer in prion diseases [PDF]
Veterinary ResearchPrion diseases are fatal and contagious brain disorders caused by a pathogenic prion protein (PrPSc) derived from the benign prion protein (PrPC). To date, there are no therapeutic substances to completely block prion diseases. Thus, the development of a
Yong-Chan Kim +2 more
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New implications for prion diseases therapy and prophylaxis [PDF]
Frontiers in Molecular NeurosciencePrion diseases are rare, fatal, progressive neurodegenerative disorders that affect both animal and human. Human prion diseases mainly present as Creutzfeldt-Jakob disease (CJD).
Fangzhou Liu, Wenqi Lü, Ling Liu
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The Future of Seed Amplification Assays and Clinical Trials
Frontiers in Aging Neuroscience, 2022 Prion-like seeded misfolding of host proteins is the leading hypothesised cause of neurodegenerative diseases. The exploitation of the mechanism in the protein misfolding cyclic amplification (PMCA) and real-time quaking-induced conversion (RT-QuIC ...
Thomas Coysh +3 more
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Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence
Scientific Reports, 2021 Cellular senescence is a stable cell cycle arrest that normal cells undergo after a finite number of divisions, in response to a variety of intrinsic and extrinsic stimuli. Although senescence is largely established and maintained by the p53/p21WAF1/CIP1
Ruchi Kumari +7 more
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PRION DISEASES. PATHOGENS OF PRION DISEASES
Актуальные проблемы теоретической и клинической медицины, 2023 Prion diseases are diseases associated with pathological proteins and based on a protein with an abnormal tertiary structure. Prions are a special class of infectious pathogens that do not have nucleic acids in their composition.
G. Seribekkyzy, V. Galimullin
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NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression
Cells, 2021 This study investigates the diagnostic and prognostic potential of different forms of tau in biofluids from patients with Creutzfeldt-Jakob disease (CJD).
David Mengel +9 more
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A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis
Nature Communications, 2020 Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive dementia. No clinical blood tests are available for diagnosis. The authors identified three miRNAs in whole-blood that are downregulated in sCJD patients, and discriminate sCJD from ...
Penny J. Norsworthy +10 more
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Structural insights into how augmin augments the mitotic spindle
Nature Communications, 2023 Cell division critically requires amplification of microtubules (MTs) in the bipolar mitotic spindle. This relies on the filamentous augmin complex that enables MT branching. Studies by Gabel et al., Zupa et al. and Travis et al.
Szymon W. Manka
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