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Chronic Wasting Disease: State of the Science [PDF]

Pathogens
Chronic wasting disease (CWD) is a prion disease affecting cervid species, both free-ranging and captive populations. As the geographic range continues to expand and disease prevalence continues to increase, CWD will have an impact on cervid populations,
Jason C. Bartz, Rebeca Benavente, Byron Caughey, Sonja Christensen, Allen Herbst, Edward A. Hoover, Candace K. Mathiason, Debbie McKenzie, Rodrigo Morales, Marc D. Schwabenlander, Daniel P. Walsh, the NC1209: North American Interdisciplinary Chronic Wasting Disease Research Consortium Members   +11 more
doaj   +6 more sources

Spatiotemporal occupancy patterns of chronic wasting disease [PDF]

Frontiers in Veterinary Science
IntroductionChronic wasting disease (CWD) among cervids in Kansas has seen a consistent rise over the years, both in terms of the number of infections and its geographical spread.
Amy J. Davis, Shane Hesting, Levi Jaster, Joseph E. Mosley, Akila Raghavan, Ram K. Raghavan, Ram K. Raghavan   +6 more
doaj   +4 more sources

Susceptibility of Beavers to Chronic Wasting Disease

Biology, 2022
Chronic wasting disease (CWD) is a contagious, fatal, neurodegenerative prion disease of cervids. The expanding geographical range and rising prevalence of CWD are increasing the risk of pathogen transfer and spillover of CWD to non-cervid sympatric ...
Allen Herbst, Serene Wohlgemuth, Jing Yang, Andrew R. Castle, Diana Martinez Moreno, Alicia Otero, Judd M. Aiken, David Westaway, Debbie McKenzie   +8 more
doaj   +5 more sources

Monitoring of chronic wasting disease (CWD) (IV)

EFSA Journal, 2023
The European Commission requested an analysis of the Chronic Wasting Disease (CWD) monitoring programme in Norway, Sweden, Finland, Iceland, Estonia, Latvia, Lithuania and Poland (9 January 2017–28 February 2022). Thirteen cases were detected in reindeer,
EFSA Panel on Biological Hazards (BIOHAZ), Konstantinos Koutsoumanis, Ana Allende, Avelino Alvarez‐Ordoñez, Declan Bolton, Sara Bover‐Cid, Marianne Chemaly, Robert Davies, Alessandra De Cesare, Lieve Herman, Friederike Hilbert, Roland Lindqvist, Maarten Nauta, Luisa Peixe, Panagiotis Skandamis, Elisabetta Suffredini, Michael W Miller, Atle Mysterud, Maria Nöremark, Marion Simmons, Michael A Tranulis, Gabriele Vaccari, Hildegunn Viljugrein, Angel Ortiz‐Pelaez, Giuseppe Ru   +24 more
doaj   +7 more sources

Prion shedding is reduced by chronic wasting disease vaccination. [PDF]

PLoS Pathogens
Chronic wasting disease (CWD) is a strictly fatal and highly contagious prion disease of wild and farmed cervids currently expanding in North America. Prion diseases are caused by conversion of the cellular prion protein to its pathological isoform PrPSc.
Hanaa Ahmed-Hassan, Dalia Abdelaziz, Yo-Ching Cheng, Kevin Low, Shirley Phan, Byron Kruger, Chimoné S Dalton, Lech Kaczmarczyk, Walker S Jackson, Sabine Gilch, Hermann M Schätzl   +10 more
doaj   +2 more sources

Genetic Variation and Strain Dynamics in Chronic Wasting Disease [PDF]

Viruses
Chronic wasting disease (CWD) is a prion disease of cervids marked by growing strain diversity and variation in host susceptibility. Central to this complexity are prion protein gene (Prnp) polymorphisms, which can modulate pathogenesis by altering the ...
Irina Zemlyankina, Melissa Razcon-Echeagaray, Gokhan Yilmaz, Kristen B. Gregg, Sabine Gilch, Samia Hannaoui   +5 more
doaj   +2 more sources

Scrapie versus Chronic Wasting Disease in White-Tailed Deer [PDF]

Emerging Infectious Diseases
White-tailed deer are susceptible to scrapie (WTD scrapie) after oronasal inoculation with the classical scrapie agent from sheep. Deer affected by WTD scrapie are difficult to differentiate from deer infected with chronic wasting disease (CWD).
Zoe J. Lambert, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, Justin J. Greenlee   +4 more
doaj   +2 more sources

Association Study of the M132L Single Nucleotide Polymorphism With Susceptibility to Chronic Wasting Disease in Korean Elk: A Meta-Analysis

Frontiers in Veterinary Science, 2022
Chronic wasting disease (CWD) is a deleterious brain proteinopathy caused by a pathogenic form of prion protein (PrPSc), which is converted from a benign form of prion protein (PrPC) encoded by the prion protein gene (PRNP).
In-Soon Roh, Yong-Chan Kim, Yong-Chan Kim, Sae-Young Won, Sae-Young Won, Kyung-Je Park, Hoo-Chang Park, Ji-Yong Hwang, Hae-Eun Kang, Hyun-Joo Sohn, Byung-Hoon Jeong, Byung-Hoon Jeong   +11 more
doaj   +1 more source

Chronic wasting disease: Emerging prions and their potential risk. [PDF]

PLoS Pathogens, 2017
Samia Hannaoui, Hermann M Schatzl, Sabine Gilch   +2 more
doaj   +3 more sources

Mouse models of chronic wasting disease: A review

Frontiers in Virology, 2023
Animal models are essential tools for investigating and understanding complex prion diseases like chronic wasting disease (CWD), an infectious prion disease of cervids (elk, deer, moose, and reindeer). Over the past several decades, numerous mouse models
Makayla Cook, Tiffany Hensley-McBain, Andrea Grindeland   +2 more
doaj   +1 more source