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Chronic Wasting Disease: State of the Science [PDF]

Pathogens
Chronic wasting disease (CWD) is a prion disease affecting cervid species, both free-ranging and captive populations. As the geographic range continues to expand and disease prevalence continues to increase, CWD will have an impact on cervid populations,
Jason C. Bartz, Rebeca Benavente, Byron Caughey, Sonja Christensen, Allen Herbst, Edward A. Hoover, Candace K. Mathiason, Debbie McKenzie, Rodrigo Morales, Marc D. Schwabenlander, Daniel P. Walsh, the NC1209: North American Interdisciplinary Chronic Wasting Disease Research Consortium Members   +11 more
doaj   +2 more sources

Horizontal Transmission of Chronic Wasting Disease in Reindeer

Emerging Infectious Diseases, 2016
We challenged reindeer by the intracranial route with the agent of chronic wasting disease sourced from white-tailed deer, mule deer, or elk and tested for horizontal transmission to naive reindeer.
S. Jo Moore, Robert Kunkle, M. Heather West Greenlee, Eric Nicholson, Jürgen Richt, Amir Hamir, W. Ray Waters, Justin Greenlee   +7 more
doaj   +2 more sources

Chronic Wasting Disease Agents in Nonhuman Primates

Emerging Infectious Diseases, 2014
Chronic wasting disease is a prion disease of cervids. Assessment of its zoonotic potential is critical. To evaluate primate susceptibility, we tested monkeys from 2 genera.
Brent Race, Kimberly D. Meade-White, Katie Phillips, James Striebel, Richard Race, Bruce Chesebro   +5 more
doaj   +2 more sources

Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease. [PDF]

, 2013
Skeletal muscle wasting contributes to impaired exercise capacity, health-related quality of life and is an independent determinant of chronic obstructive pulmonary disease.
Langen, R.C.J., Schols, A.M.W.J., Remels, A.H.V., Gosker, H.R.; id_orcid, Gosker, H.R.   +4 more
core   +2 more sources

Preventing Chronic Disease (PCD) [PDF]

This collection of articles in Preventing Chronic Disease (PCD) brings together scientists and practitioners from the breadth of public health and the social sciences to demonstrate how geospatial perspectives can contribute to understanding and ...

core   +6 more sources

PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer [PDF]

, 2002
Up to 15% of free-ranging mule deer in northeastern Colorado and southeastern Wyoming, USA, are afflicted with a prion disease, or transmissible spongiform encephalopathy (TSE), known as chronic wasting disease (CWD).
Keulen, L.J.M., van, van Keulen, L.J.M., Miller, M.W., Oesch, B., Hoover, E.A., Langeveld, J.P.M., Sigurdson, C.J., Barillas-Mury, C.   +7 more
core   +1 more source

Prion protein polymorphisms affect chronic wasting disease progression. [PDF]

PLoS ONE, 2011
Analysis of the PRNP gene in cervids naturally infected with chronic wasting disease (CWD) suggested that PRNP polymorphisms affect the susceptibility of deer to infection.
Chad J Johnson, Allen Herbst, Camilo Duque-Velasquez, Joshua P Vanderloo, Phil Bochsler, Rick Chappell, Debbie McKenzie   +6 more
doaj   +1 more source

Ticks harbor and excrete chronic wasting disease prions

Scientific Reports, 2023
Chronic wasting disease (CWD) is a fatal neurodegenerative disease caused by infectious prions (PrPCWD) affecting cervids. Circulating PrPCWD in blood may pose a risk for indirect transmission by way of hematophagous ectoparasites acting as mechanical ...
H. N. Inzalaco, F. Bravo-Risi, R. Morales, D. P. Walsh, D. J. Storm, J. A. Pedersen, W. C. Turner, S. S. Lichtenberg   +7 more
doaj   +1 more source

Genetic variability of the prion protein gene (PRNP) in wild ruminants from Italy and Scotland [PDF]

, 2009
The genetics of the prion protein gene (PRNP) play a crucial role in determining the relative susceptibility to transmissible spongiform encephalopathies (TSEs) in several mammalian species.
Acutis, Pier Luigi, Pier Luigi Acutis, Ezio Ferroglio, Simone Peletto, Hugh W. Reid, Perucchini, Matteo, Serena Robetto, Acin, Cristina, Bozzetta, Elena, Reid, Hugh W., Dalgleish, Mark P., Orusa, Riccardo, Elena Bozzetta, Ferroglio, Ezio, Sacchi, Paola, Paula Stewart, Daniela Meloni, Wilfred Goldmann, Meloni, Daniela, Gennero, Silvia, Riccardo Orusa, Roberto Rasero, Rasero, Roberto, Cristina Acín, Matteo Perucchini, Mark P. Dalgleish, Goldmann, Wilfred, Stewart, Paula, Maria Caramelli, Silvia Gennero, Caramelli, Maria, Robetto, Serena, Peletto, Simone, Paola Sacchi   +33 more
core   +1 more source

Gene-Edited Cell Models to Study Chronic Wasting Disease

Viruses, 2022
Prion diseases are fatal infectious neurodegenerative disorders affecting both humans and animals. They are caused by the misfolded isoform of the cellular prion protein (PrPC), PrPSc, and currently no options exist to prevent or cure prion diseases ...
Simrika Thapa, Cristobal Marrero Winkens, Waqas Tahir, Maria I. Arifin, Sabine Gilch, Hermann M. Schatzl   +5 more
doaj   +1 more source