Biomarkers of systemic inflammation and growth in early infancy are associated with stunting in young Tanzanian children [PDF]
, 2018 Stunting can afflict up to one-third of children in resource-constrained countries. We hypothesized that low-grade systemic inflammation (defined as elevations in serum C-reactive protein or alpha-1-acid glycoprotein) in infancy suppresses the growth ...
Aboud, Said +9 more
core +1 more source
Exposure Risk of Chronic Wasting Disease in Humans
Viruses, 2020 The majority of human prion diseases are sporadic, but acquired disease can occur, as seen with variant Creutzfeldt–Jakob disease (vCJD) following consumption of bovine spongiform encephalopathy (BSE).
Satish K. Nemani +4 more
doaj +1 more source
Large animal models for chronic wasting disease [PDF]
Cell and Tissue Research, 2022 Chronic wasting disease (CWD) is a fatal neurodegenerative prion disease of cervid species including deer, elk, moose and reindeer. The disease has shown both geographic and species expansion since its discovery in the late 1960's and is now recognized in captive and free-ranging cervid populations in North America, Asia and Europe.
openaire +2 more sources
Invariant algebraic surfaces of a chronic wasting disease model
上海师范大学学报. 自然科学版, 2021 In this paper we study a chronic wasting disease (CWD) model of three dimensional ordinary differential equations. We use the method of characteristic curves to give a complete classification of this system with invariant algebraic surfaces. In addition,
YANG Yang, XIE Feng
doaj +1 more source
Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]
, 2018 Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter +7 more
core +1 more source
Susceptibilities of Nonhuman Primates to Chronic Wasting Disease
Emerging Infectious Diseases, 2009 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. Human susceptibility to CWD remains unproven despite likely exposure to CWD-infected cervids.
Brent Race +16 more
doaj +1 more source
Spatiotemporal epizootiology of chronic wasting disease in Wisconsin deer
Ecosphere, 2023 Chronic wasting disease (CWD) is a fatal neurological disease of cervids caused by a misfolded protein with no vaccines or other cures to prevent infection and death.
Michael D. Samuel
doaj +1 more source
Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk [PDF]
, 2019 BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα ...
Dong, Jiangling +7 more
core +2 more sources
Prion seeding activity in DNA extractions: implications for laboratory biosafety
PrionInfectious prions (PrPSc) are largely resistant to proteolytic digestion, including proteinase K (PK) digestion. While nucleic acid extracts are generally considered non-infectious from a classical microbiology context (i.e.
Sarah C. Gresch +10 more
doaj +1 more source
Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models
Journal of Cachexia, Sarcopenia and Muscle, 2023 Skeletal muscle wasting, whether related to physiological ageing, muscle disuse or to an underlying chronic disease, is a key determinant to quality of life and mortality.
Pauline Henrot +8 more
doaj +1 more source