Results 41 to 50 of about 59,618 (284)

Spatiotemporal epizootiology of chronic wasting disease in Wisconsin deer

Ecosphere, 2023
Chronic wasting disease (CWD) is a fatal neurological disease of cervids caused by a misfolded protein with no vaccines or other cures to prevent infection and death.
Michael D. Samuel
doaj   +1 more source

Prion seeding activity in DNA extractions: implications for laboratory biosafety

Prion
Infectious prions (PrPSc) are largely resistant to proteolytic digestion, including proteinase K (PK) digestion. While nucleic acid extracts are generally considered non-infectious from a classical microbiology context (i.e.
Sarah C. Gresch, Tamara Morrill, Maddy Ellis-Cramer, Maria Arifin, Lexi E. Frank, Jason C. Bartz, Marc D. Schwabenlander, Tiffany M. Wolf, Gordon B. Mitchell, Jiewen Guan, Peter A. Larsen   +10 more
doaj   +1 more source

Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models

Journal of Cachexia, Sarcopenia and Muscle, 2023
Skeletal muscle wasting, whether related to physiological ageing, muscle disuse or to an underlying chronic disease, is a key determinant to quality of life and mortality.
Pauline Henrot, Léo Blervaque, Isabelle Dupin, Maéva Zysman, Pauline Esteves, Fares Gouzi, Maurice Hayot, Pascal Pomiès, Patrick Berger   +8 more
doaj   +1 more source

PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer

, 2002
Up to 15% of free-ranging mule deer in northeastern Colorado and southeastern Wyoming, USA, are afflicted with a prion disease, or transmissible spongiform encephalopathy (TSE), known as chronic wasting disease (CWD).
Keulen, L.J.M., van, van Keulen, L.J.M., Miller, M.W., Oesch, B., Hoover, E.A., Langeveld, J.P.M., Sigurdson, C.J., Barillas-Mury, C.   +7 more
core   +1 more source

Prevalence and associated factors of protein- energy wasting among patients with chronic kidney disease at Mulago hospital, Kampala-Uganda: a cross-sectional study

BMC Nephrology, 2018
Background Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20–25% of patients with chronic kidney disease and can lead to a high morbidity and mortality
Lydia Namuyimbwa, Collins Atuheire, Joel Okullo, Robert Kalyesubula   +3 more
doaj   +1 more source

Failure To Detect Prion Infectivity in Ticks following Prion-Infected Blood Meal

mSphere, 2020
Chronic wasting disease (CWD) is an emerging and fatal contagious prion disease that affects cervids, including mule deer, white-tailed deer, black-tailed deer, red deer reindeer, elk, and moose. CWD prions are widely distributed throughout the bodies of
Ronald A. Shikiya, Anthony E. Kincaid, Jason C. Bartz, Travis J. Bourret   +3 more
doaj   +1 more source

Chronic kidney disease and premature ageing

, 2014
Chronic kidney disease (CKD) shares many phenotypic similarities with other chronic diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and rheumatoid arthritis.
Shiels, PG, Kotanko, P., Shiels, P.G., Stenvinkel, P,, Stenvinkel, P., Kotanko, P, Kooman, JP, Schols, A.M., Kooman, J.P., Schols, AMWJ   +9 more
core   +1 more source

Generation of human chronic wasting disease in transgenic mice

Acta Neuropathologica Communications, 2021
Chronic wasting disease (CWD) is a cervid prion disease caused by the accumulation of an infectious misfolded conformer (PrPSc) of cellular prion protein (PrPC). It has been spreading rapidly in North America and also found in Asia and Europe.
Zerui Wang, Kefeng Qin, Manuel V. Camacho, Ignazio Cali, Jue Yuan, Pingping Shen, Justin Greenlee, Qingzhong Kong, James A. Mastrianni, Wen-Quan Zou   +9 more
doaj   +1 more source

Premature aging in chronic kidney disease and chronic obstructive pulmonary disease

, 2015
Purpose of review: There is increasing clinical and pathophysiological evidence that a premature aging process is involved in the pathogenesis of systemic complications of many chronic organ diseases, which result in analogous phenotypes, including ...
Shiels, PG, Stenvinkel, Peter, Kooman, Jeroen P., Shiels, P.G., Stenvinkel, P,, Stenvinkel, P., Kooman, JP, Shiels, Paul G., Kooman, J.P.   +8 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source