Results 51 to 60 of about 54,330 (142)
Mechanisms of muscle wasting in chronic kidney disease [PDF]
Nature Reviews Nephrology, 2014 In patients with chronic kidney disease (CKD), loss of cellular proteins increases the risks of morbidity and mortality. Persistence of muscle protein catabolism in CKD results in striking losses of muscle proteins as whole-body protein turnover is great; even small but persistent imbalances between protein synthesis and degradation cause substantial ...
Xiaonan H, Wang, William E, Mitch
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Prospective fecal microbiomic biomarkers for chronic wasting disease
Microbiology SpectrumChronic wasting disease (CWD) is a naturally occurring prion disease in cervids that has been rapidly proliferating in the United States. Here, we investigated a potential link between CWD infection and gut microbiome by analyzing 50 fecal samples ...
Adam Didier +12 more
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Occurrence, Transmission, and Zoonotic Potential of Chronic Wasting Disease
Emerging Infectious Diseases, 2012 Chronic wasting disease (CWD) is a fatal, transmissible prion disease that affects captive and free-ranging deer, elk, and moose. Although the zoonotic potential of CWD is considered low, identification of multiple CWD strains and the potential for agent
Samuel E. Saunders +2 more
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Inactivation of chronic wasting disease prions using sodium hypochlorite.
PLoS ONE, 2019 Chronic wasting disease (CWD) is a fatal prion disease that can infect deer, elk and moose. CWD has now been detected in 26 states of the USA, 3 Canadian provinces, South Korea, Norway, Sweden and Finland.
Katie Williams +3 more
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Chronic Wasting Disease: Current Assessment of Transmissibility [PDF]
Current Issues in Molecular Biology, 2019 Chronic wasting disease (CWD) is a prion disease of cervids characterized by clini- cal symptoms of progressive weight loss, abnormal behaviour and excessive salivation. Incidents have been reported in North America and Korea as well as in Europe. Current knowledge, based on in vitro and in vivo experiments, suggests direct CWD transmis- sion to humans
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Molecular Barriers to Zoonotic Transmission of Prions
Emerging Infectious Diseases, 2014 The risks posed to human health by individual animal prion diseases cannot be determined a priori and are difficult to address empirically. The fundamental event in prion disease pathogenesis is thought to be the seeded conversion of normal prion protein
Marcelo A. Barria +8 more
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Aggregation and environmental transmission in chronic wasting disease
Mathematical Biosciences and Engineering, 2015 Disease transmission depends on the interplay between the infectious agent and the behavior of the host. Some diseases, such as Chronic Wasting Disease, can be transmitted directly between hosts as well as indirectly via the environment. The social behavior of hosts affects both of these pathways, and a successful intervention requires knowledge of the
Olga Vasilyeva +2 more
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Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
Emerging Infectious Diseases, 2017 Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95+, into mice resulted in infection. Thus, emergent CWD
Allen Herbst +4 more
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Wasting in Chronic Gastrointestinal Diseases [PDF]
The Journal of Nutrition, 1999 openaire +2 more sources
Cachexia with ascites: a diagnostic dilemma—a case report
MGM Journal of Medical SciencesCachexia, also known as “wasting syndrome,” is a complex condition characterized by severe weight loss, muscle wasting, fatigue, and often a decrease in body fat. It is commonly associated with chronic illnesses such as cancer, chronic kidney disease, or
Harvinder Kaur Palaha +7 more
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