Results 71 to 80 of about 59,618 (284)

Chronic Wasting Disease Drives Population Decline of White-Tailed Deer. [PDF]

PLoS ONE, 2016
Chronic wasting disease (CWD) is an invariably fatal transmissible spongiform encephalopathy of white-tailed deer, mule deer, elk, and moose. Despite a 100% fatality rate, areas of high prevalence, and increasingly expanding geographic endemic areas ...
David R Edmunds, Matthew J Kauffman, Brant A Schumaker, Frederick G Lindzey, Walter E Cook, Terry J Kreeger, Ronald G Grogan, Todd E Cornish   +7 more
doaj   +1 more source

Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure. [PDF]

, 2009
Rationale Cigarette smoking is the most commonly encountered risk factor for COPD, reflected by irreversible airflow limitation frequently associated with airspace enlargement and pulmonary inflammation.
Brusselle, G.G., Wouters, E.F., Bracke, K.R., Joos, G.F., Ward, K.A., Steele, C., Gosker, H.R.; id_orcid, Langen, R.C., Schols, A.M., Gosker, H.R.   +9 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Susceptibility of Domestic Cats to Chronic Wasting Disease [PDF]

Journal of Virology, 2013
ABSTRACT Domestic and nondomestic cats have been shown to be susceptible to feline spongiform encephalopathy (FSE), almost certainly caused by consumption of bovine spongiform encephalopathy (BSE)-contaminated meat. Because domestic and free-ranging nondomestic felids scavenge cervid carcasses, including those in areas affected ...
Candace K, Mathiason, Amy V, Nalls, Davis M, Seelig, Susan L, Kraft, Kevin, Carnes, Kelly R, Anderson, Jeanette, Hayes-Klug, Edward A, Hoover   +7 more
openaire   +2 more sources

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Mechanisms of muscle wasting in chronic kidney disease [PDF]

Nature Reviews Nephrology, 2014
In patients with chronic kidney disease (CKD), loss of cellular proteins increases the risks of morbidity and mortality. Persistence of muscle protein catabolism in CKD results in striking losses of muscle proteins as whole-body protein turnover is great; even small but persistent imbalances between protein synthesis and degradation cause substantial ...
Xiaonan H, Wang, William E, Mitch
openaire   +2 more sources

Characterization of the prion protein in relation to normal cellular function and in disease [PDF]

, 2012
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of rare and fatal neurodegenerative disorders that can affect both human and animals.
Wik, Lotta
core  

Nutritional targets to enhance exercise performance in chronic obstructive pulmonary disease

, 2012
PURPOSE OF REVIEW: This review presents current knowledge regarding the rationale and efficacy of nutrition as an ergogenic aid to enhance the effects of exercise and training in chronic obstructive pulmonary disease (COPD). RECENT FINDINGS: Altered body
Schols, A.M.W.J., Steiner, M.C., van de Bool, C.   +2 more
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

The role of exercise and PGC1alpha in inflammation and chronic disease [PDF]

, 2008
Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1alpha has recently been shown to regulate several exercise-associated aspects of ...
Handschin, Christoph, Spiegelman, Bruce M.   +1 more
core