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PrionHome: a database of prions and other sequences relevant to prion phenomena.
PLoS ONE, 2012 Prions are units of propagation of an altered state of a protein or proteins; prions can propagate from organism to organism, through cooption of other protein copies.
Djamel Harbi +7 more
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Creutzfeldt-Jakob Disease Incidence, South Korea, 2001–2019
Emerging Infectious Diseases, 2022 We found increasing trends of Creutzfeldt-Jakob disease (CJD) cases and annual incidence in South Korea during 2001–2019. We noted relatively low (5.7%) distribution of familial CJD.
Yong-Chan Kim, Byung-Hoon Jeong
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Immunomodulation for prion and prion-related diseases [PDF]
Expert Review of Vaccines, 2010 Prion diseases are a unique category of illness, affecting both animals and humans, where the underlying pathogenesis is related to a conformational change of a normal self protein called cellular prion protein to a pathological and infectious conformer known as scrapie prion protein (PrP(Sc)). Currently, all prion diseases lack effective treatment and
Thomas, Wisniewski, Fernando, Goñi
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Human J-Domain Protein DnaJB6 Protects Yeast from [PSI+] Prion Toxicity
Biology, 2022 Human J-domain protein (JDP) DnaJB6 has a broad and potent activity that prevents formation of amyloid by polypeptides such as polyglutamine, A-beta, and alpha-synuclein, related to Huntington’s, Alzheimer’s, and Parkinson’s diseases, respectively.
Richard E. Dolder +3 more
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Nanoimaging for prion related diseases [PDF]
Prion, 2010 Misfolding and aggregation of prion proteins is linked to a number of neurodegenerative disorders such as Creutzfeldt-Jacob disease (CJD) and its variants: Kuru, Gerstmann-Straussler-Scheinker syndrome and fatal familial insomnia. In prion diseases, infectious particles are proteins that propagate by transmitting a misfolded state of a protein, leading
Alexey V, Krasnoslobodtsev +4 more
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Uptake, Retention, and Excretion of Infectious Prions by Experimentally Exposed Earthworms
Emerging Infectious Diseases, 2021 Prions are proteinaceous infectious agents that can be transmitted through various components of the environment, including soil particles. We found that earthworms exposed to prion-contaminated soil can bind, retain, and excrete prions, which remain ...
Sandra Pritzkow +3 more
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Neural Regeneration Research, 2021 The baker’s yeast Saccharomyces (S.) cerevisiae is a single-celled eukaryotic model organism widely used in research on life sciences. Being a unicellular organism, S. cerevisiae has some evident limitations in application to neuroscience. However, yeast
Takao Ishikawa
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THERPA: A small molecule database related to prion protein regulation and prion diseases progression [PDF]
Prion, 2018 Prion diseases are fatal neurodegenerative disorders that affect humans and animals. Although various small molecules have been evaluated for application in the treatment of prion diseases, none have been shown to be efficacious. Expanding our knowledge of these molecules is important for understanding of the complex mechanisms of prion diseases.
Sol Moe Lee +6 more
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Identification of Prion Disease-Related Somatic Mutations in the Prion Protein Gene (PRNP) in Cancer Patients [PDF]
Cells, 2020 Prion diseases are caused by misfolded prion protein (PrPSc) and are accompanied by spongiform vacuolation of brain lesions. Approximately three centuries have passed since prion diseases were first discovered around the world; however, the exact role of certain factors affecting the causative agent of prion diseases is still debatable.
Yong-Chan Kim +2 more
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Stability and Cu(II) Binding of Prion Protein Variants Related to Inherited Human Prion Diseases [PDF]
Biophysical Journal, 2003 All inherited forms of human prion diseases are linked with mutations in the prion protein (PrP) gene. Here we have investigated the stability and Cu(II) binding properties of three recombinant variants of murine full-length PrP(23-231)-containing destabilizing point mutations that are associated with human Gerstmann-Sträussler-Scheinker disease (F198S)
Cereghetti GM +3 more
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