Silent Propagation of Classical Scrapie Prions in Homozygous K222 Transgenic Mice [PDF]
Emerging Infectious DiseasesClassical scrapie affects sheep and goats. To control prevalence in sheep, the European Union initiated breeding programs targeting resilient genotypes.
Natalia Fernández-Borges +5 more
doaj +2 more sources
Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness [PDF]
Acta Neuropathologica CommunicationsTransgenic mice overexpressing bank vole prion protein with the isoleucine 109 polymorphism, TgVole(I109)4x, develop spontaneous neurodegenerative disease with sex-dependent onset, averaging 170 days in females and 200 days in males at terminal stage ...
Hasier Eraña +31 more
doaj +2 more sources
Chronic Wasting Disease in Farmed Cervids, South Korea, 2001–2024 [PDF]
Emerging Infectious DiseasesChronic wasting disease (CWD) was identified in imported elk in South Korea in 2001 and has spread among cervids nationwide. The country’s surveillance and control policy culls cervids from any CWD-positive farms, and prevalence during 2020–2024 was
Young Pyo Choi +6 more
doaj +2 more sources
Detection of Chronic Wasting Disease Prions in Raw, Processed, and Cooked Elk Meat, Texas, USA [PDF]
Emerging Infectious DiseasesWe describe chronic wasting disease (CWD) prion detection in raw and cooked meat from a CWD-positive elk. We found limited zoonotic potential in CWD prions from those meat products.
Rebeca Benavente +8 more
doaj +2 more sources
Detection of Prions in Wild Pigs (Sus scrofa) from Areas with Reported Chronic Wasting Disease Cases, United States [PDF]
Emerging Infectious DiseasesUsing a prion amplification assay, we identified prions in tissues from wild pigs (Sus scrofa) living in areas of the United States with variable chronic wasting disease (CWD) epidemiology.
Paulina Soto +14 more
doaj +2 more sources
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
Emerging Infectious Diseases, 2017 Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95+, into mice resulted in infection. Thus, emergent CWD
Allen Herbst +4 more
doaj +1 more source
, 2016 Prions are infectious protein polymers that have been found to cause fatal diseases in mammals. Prions have also been identified in fungi (yeast and filamentous fungi), where they behave as cytoplasmic non-Mendelian genetic elements.
Aguzzi +122 more
core +2 more sources
Assessing Prion Infectivity of Human Urine in Sporadic Creutzfeldt-Jakob Disease
Emerging Infectious Diseases, 2012 Prion diseases are neurodegenerative conditions associated with a misfolded and infectious protein, scrapie prion protein (PrPSc). PrPSc propagate prion diseases within and between species and thus pose risks to public health.
Silvio Notari +12 more
doaj +1 more source
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]
, 2008 Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano +8 more
core +3 more sources
Yeast Models for Amyloids and Prions: Environmental Modulation and Drug Discovery
Molecules, 2019 Amyloids are self-perpetuating protein aggregates causing neurodegenerative diseases in mammals. Prions are transmissible protein isoforms (usually of amyloid nature).
Tatiana A. Chernova +2 more
doaj +1 more source