Results 41 to 50 of about 37,766 (292)

Heterologous prion-forming proteins interact to cross-seed aggregation in Saccharomyces cerevisiae [PDF]

, 2017
The early stages of protein misfolding remain incompletely understood, as most mammalian proteinopathies are only detected after irreversible protein aggregates have formed.
Keefer, Kathryn M, Stein, Kevin C, true, Heather L   +2 more
core   +2 more sources

Deposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie

Frontiers in Neuroscience, 2015
Organotypic cerebellar slices represent a suitable model for characterizing and manipulating prion replication in complex cell environments. Organotypic slices recapitulate prion pathology and are amenable to drug testing in the absence of a blood-brain ...
Hanna eWolf, Andre eHossinger, Andrea eFehlinger, Sven eBuettner, Valerie eSim, Debbie eMcKenzie, Ina Maja Vorberg, Ina Maja Vorberg   +7 more
doaj   +1 more source

Development of a methodology for large-scale production of prions for biological and structural studies

Frontiers in Molecular Biosciences, 2023
Prion diseases are a group of infectious neurodegenerative diseases produced by the conversion of the normal prion protein (PrPC) into the disease-associated form (PrPSc).
Luis Concha-Marambio, Luis Concha-Marambio, Fei Wang, Enrique Armijo, Damian Gorski, Frank Ramirez, Andrew Scowcroft, Sandra Pritzkow, Claudio Soto, Claudio Soto   +9 more
doaj   +1 more source

Efficient interspecies transmission of synthetic prions.

PLoS Pathogens, 2021
Prions are comprised solely of PrPSc, the misfolded self-propagating conformation of the cellular protein, PrPC. Synthetic prions are generated in vitro from minimal components and cause bona fide prion disease in animals.
Alyssa J Block, Ronald A Shikiya, Thomas E Eckland, Anthony E Kincaid, Ryan W Walters, Jiyan Ma, Jason C Bartz   +6 more
doaj   +1 more source

Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. [PDF]

PLoS ONE, 2017
In our previous study, we demonstrated the propagation of mouse-passaged scrapie isolates with long incubation periods (L-type) derived from natural Japanese sheep scrapie cases in murine hypothalamic GT1-7 cells, along with disease-associated prion ...
Kohtaro Miyazawa, Kentaro Masujin, Hiroyuki Okada, Yuko Ushiki-Kaku, Yuichi Matsuura, Takashi Yokoyama   +5 more
doaj   +1 more source

MicroRNAs and depression

Neurobiology of Disease, 2012
With an estimated life-time prevalence of 15 to 17% and an incapacitating illness in 50% of cases, depressive spectrum disorders represent a heavy public health burden.
Sophie Mouillet-Richard, Anne Baudry, Jean-Marie Launay, Odile Kellermann   +3 more
doaj   +1 more source

Cross infection control measures and the treatment of patients at risk of Creutzfeldt Jakob disease in UK general dental practice [PDF]

, 2001
AIMS: To determine the suitability of key infection control measures currently employed in UK dental practice for delivery of dental care to patients at risk of prion diseases.
A Smith, AF Hill, AF Hill, C P Sweeney, CM Van Duijn, DH Adams, DM Taylor, F Blanquet-Gossard, H Ashraf, IF Laurenson, J Bagg, K Arakawa, K M Roy, L Ingrosso, ME Bruce, R Dobson, RG Will, RG Will, RI Carp, RT Johnson, S Collins, T Sharp, Z Davanipour   +22 more
core   +1 more source

Protease-sensitive synthetic prions. [PDF]

PLoS Pathogens, 2010
Prions arise when the cellular prion protein (PrP(C)) undergoes a self-propagating conformational change; the resulting infectious conformer is designated PrP(Sc).
David W Colby, Rachel Wain, Ilia V Baskakov, Giuseppe Legname, Christina G Palmer, Hoang-Oanh B Nguyen, Azucena Lemus, Fred E Cohen, Stephen J DeArmond, Stanley B Prusiner   +9 more
doaj   +1 more source

Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner. [PDF]

, 2017
Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD). The absence of a human cell culture model that replicates human prions has hampered prion disease research for decades.
Alibhai, James, Chandran, Siddharthan, Head, Mark W, Ironside, James W, Krejciova, Zuzana, Krencik, Robert, Manson, Jean, Rzechorzek, Nina M, Ullian, Erik M, Zhao, Chen   +9 more
core   +1 more source

Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration

Biomolecules
Slow-onset neurodegenerative disease in a low-expresser 2N4R P301L transgenic (Tg) mouse model is marked by neuroinflammation and by differing patterns of CNS deposition and accumulation of tau conformers, with such heterogeneities present even within ...
Nathalie Daude, Ivana Machado, Luis Arce, Jing Yang, David Westaway   +4 more
doaj   +1 more source