Results 31 to 40 of about 48,246 (290)
Bioactive Materials, 2021 Evidence suggests that increased level/aggregation of beta-amyloid (Aβ) peptides initiate neurodegeneration and subsequent development of Alzheimer's disease (AD). At present, there is no effective treatment for AD. In this study, we reported the effects
Bibin G. Anand +6 more
doaj +1 more source
Mineral licks as environmental reservoirs of chronic wasting disease prions
PLoS ONE, 2018 Chronic wasting disease (CWD) is a fatal neurodegenerative disease of deer, elk, moose, and reindeer (cervids) caused by misfolded prion proteins. The disease has been reported across North America and recently discovered in northern Europe. Transmission
Ian H Plummer +4 more
semanticscholar +1 more source
Resistance of soil-bound prions to rumen digestion. [PDF]
PLoS ONE, 2012 Before prion uptake and infection can occur in the lower gastrointestinal system, ingested prions are subjected to anaerobic digestion in the rumen of cervids and bovids.
Samuel E Saunders +2 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Prion diseases are a group of infectious neurodegenerative diseases produced by the conversion of the normal prion protein (PrPC) into the disease-associated form (PrPSc).
Luis Concha-Marambio +9 more
doaj +1 more source
Pathogens, 2018 PrPSc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt–Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer), as ...
H. Wille, J. Requena
semanticscholar +1 more source
Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. [PDF]
PLoS ONE, 2017 In our previous study, we demonstrated the propagation of mouse-passaged scrapie isolates with long incubation periods (L-type) derived from natural Japanese sheep scrapie cases in murine hypothalamic GT1-7 cells, along with disease-associated prion ...
Kohtaro Miyazawa +5 more
doaj +1 more source
Proceedings of the National Academy of Sciences, 1984 Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP).
openaire +3 more sources
Aβ prions and the pathobiology of Alzheimer’s disease
Cold Spring Harbor Perspectives in Medicine, 2018 Alzheimer’s disease (AD) is the most common neurodegenerative disease in humans and will pose a considerable challenge to healthcare systems in the coming years.
J. Watts, S. Prusiner
semanticscholar +1 more source
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source
Defining the conformational features of anchorless, poorly neuroinvasive prions. [PDF]
PLoS Pathogens, 2013 Infectious prions cause diverse clinical signs and form an extraordinary range of structures, from amorphous aggregates to fibrils. How the conformation of a prion dictates the disease phenotype remains unclear.
Cyrus Bett +9 more
doaj +1 more source