Results 1 to 10 of about 5,518 (179)
Implication of type 4 NADPH oxidase (NOX4) in tauopathy [PDF]
Redox Biology, 2022 Aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as Alzheimer's disease (AD) and frontotemporal dementia.
Pilar Negredo +2 more
exaly +4 more sources
Astrocytes in Tauopathies [PDF]
Frontiers in Neurology, 2020 Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and
Matthew J. Reid +4 more
doaj +4 more sources
Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes.
Neurobiology of Disease, 2021 Aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like Alzheimer's disease. Previously we showed loss of function mutations in the gene encoding the poly(A) RNA binding protein SUT-2/MSUT2 ...
Rebecca L. Kow +8 more
doaj +1 more source
Positron Emission Tomography in Animal Models of Tauopathies
Frontiers in Aging Neuroscience, 2022 The microtubule-associated protein tau (MAPT) plays an important role in Alzheimer’s disease and primary tauopathy diseases. The abnormal accumulation of tau contributes to the development of neurotoxicity, inflammation, neurodegeneration, and cognitive ...
Lei Cao +7 more
doaj +1 more source
Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders. [PDF]
PLoS ONE, 2011 Tauopathies, including Alzheimer's Disease, are the most frequent neurodegenerative diseases in elderly people and cause various cognitive, behavioural and motor defects, but also progressive language disorders. For communication and social interactions,
Clément Menuet +7 more
doaj +1 more source
Seizures are a druggable mechanistic link between TBI and subsequent tauopathy
eLife, 2021 Traumatic brain injury (TBI) is a prominent risk factor for dementias including tauopathies like chronic traumatic encephalopathy (CTE). The mechanisms that promote prion-like spreading of Tau aggregates after TBI are not fully understood, in part due to
Hadeel Alyenbaawi +8 more
doaj +1 more source
Immunotherapy for Tauopathies [PDF]
Journal of Molecular Neuroscience, 2011 Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach.
Jiaping, Gu, Einar M, Sigurdsson
openaire +2 more sources
Neurobiology of Disease, 2021 Perturbed neuronal Ca2+ homeostasis is implicated in Alzheimer's disease, which has primarily been demonstrated in mice with amyloid-β deposits but to a lesser and more variable extent in tauopathy models.In this study, we injected AAV to express Ca2 ...
Qian Wu +8 more
doaj +1 more source
Seminars in Neurology, 2019 Tauopathies are rare neurodegenerative disorders related to microtubule-associated protein tau, which functions to stabilize microtubules. Pathological changes caused by overexpression or hyperphosphorylation of tau lead to the disengagement of tau from microtubules and accumulation of toxic intracellular inclusions.
Farwa, Ali, Keith, Josephs
openaire +2 more sources
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
Signal Transduction and Targeted Therapy, 2023 Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer’s disease.
Zhuchi Tu +13 more
doaj +1 more source