Results 21 to 30 of about 19,301 (220)
Frontiers in Physics, 2023 Introduction: Current small-animal PET instrumentation provides sufficient resolution, sensitivity, and quantitative accurate information on the radiotracer distribution within the whole body.
Thomas Wanek +12 more
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Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures
Biomolecules, 2022 Tau pathology extends throughout the brain in a prion-like fashion through connected brain regions. However, the details of the underlying mechanisms are incompletely understood.
Dhwani S. Korde, Christian Humpel
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Brain Research Bulletin, 2016 Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly understood; current nosological concepts are largely based on these molecular signatures of protein aggregates which also provide valuable tools for neuropathological ...
Thomas, Arendt +2 more
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Astrogliopathy in Tauopathies [PDF]
Neuroglia, 2018 Astrocytes are involved in many diseases of the central nervous system, not only as reactive cells to neuronal damage but also as primary actors in the pathological process. Astrogliopathy is a term used to designate the involvement of astrocytes as key elements in the pathogenesis and pathology of diseases and injuries of the central nervous system ...
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Primary retinal tauopathy: A tauopathy with a distinct molecular pattern
Alzheimer's & Dementia, 2023 AbstractBACKGROUNDPhosphorylated tau (p‐tau) accumulation, a hallmark of Alzheimer's disease (AD), can also be found in the retina. However, it is uncertain whether it is linked to AD or another tauopathy.METHODSRetinas from 164 individuals, with and without AD, were analyzed for p‐tau accumulation and its relationship with age, dementia, and vision ...
Walkiewicz, Grzegorz +11 more
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Pneumonia initiates a tauopathy [PDF]
The FASEB Journal, 2021 Abstract Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment
Ron Balczon +15 more
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PLoS ONE, 2013 Cell adhesion molecules are important structural substrates, required for synaptic plasticity and synaptogenesis. CAMs differ widely in their expression throughout different brain regions and their specific structural and functional roles in the brain ...
Hervé Maurin +8 more
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Curcumin as a Holistic Treatment for Tau Pathology
Frontiers in Pharmacology, 2022 Global forecasts for prevalence of Alzheimer’s Disease (AD) estimate that 152.8 million people will have dementia in 2050, a sharp rise from 57.4 million in 2019 (GBD 2019).
Lovesha Sivanantharajah, Amritpal Mudher
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Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration
Frontiers in Neuroscience, 2019 ObjectiveWhile Alzheimer’s disease is associated with inner retina thinning measured by spectral-domain optical coherence tomography (SD-OCT), our previous cross-sectional study suggested outer retina thinning in frontotemporal degeneration (FTD ...
Benjamin J. Kim +9 more
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Neurobiology of Disease, 2014 Tau.P301L transgenic mice suffer precocious mortality between ages 8 and 11 months, resulting from upper airway defects caused by tauopathy in autonomic brainstem circuits that control breathing (Dutschmann et al., 2010). In individual mice, the clinical
Natalia Crespo-Biel +6 more
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