Results 21 to 30 of about 5,518 (179)
Neurobiology of Disease, 2012 The postoperative cognitive decline resulting from volatile anesthesia is gaining acceptance as a major health problem. The common anesthetic isoflurane is suspected to precipitate neurodegeneration in Alzheimer's disease by unknown mechanisms.
Clément Menuet +8 more
doaj +1 more source
Frontiers in Neuroscience, 2023 Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases, collectively termed tauopathy.
Naruhiko Sahara, Rin Yanai
doaj +1 more source
Modeling tauopathy: a range of complementary approaches [PDF]
, 2005 The large group of neurodegenerative diseases which feature abnormal metabolism and accumulation of tau protein (tauopathies) characteristically produce a multiplicity of cellular and systemic abnormalities in human patients.
Hall, Garth F., Yao, Jun
core +1 more source
Nature Communications, 2020 Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes
M. Catarina Silva +9 more
doaj +1 more source
Frontiers in Physiology, 2023 Rationale: Although sleep apnea occurs in over 50% of individuals with Alzheimer’s Disease (AD) or related tauopathies, little is known concerning the potential role of tauopathy in the pathogenesis of sleep apnea.
Alexandria B. Marciante +5 more
doaj +1 more source
Brain Research Bulletin, 2016 Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly understood; current nosological concepts are largely based on these molecular signatures of protein aggregates which also provide valuable tools for neuropathological ...
Thomas, Arendt +2 more
openaire +2 more sources
Sex-Related Motor Deficits in the Tau-P301L Mouse Model
Biomedicines, 2021 The contribution of mouse models for basic and translational research at different levels is important to understand neurodegenerative diseases, including tauopathies, by studying the alterations in the corresponding mouse models in detail.
Luana Cristina Camargo +8 more
doaj +1 more source
Early alterations of neurovascular unit in the retina in mouse models of tauopathy
Acta Neuropathologica Communications, 2021 The retina, as the only visually accessible tissue in the central nervous system, has attracted significant attention for evaluating it as a biomarker for neurodegenerative diseases.
Fan Xia +9 more
doaj +1 more source
, 2012 Tauopathies are age-related neurodegenerative diseases that are characterized by the presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered as a microtubule-associated protein, it has been hypothesized that neurodegeneration results from a loss of the ability of tau to associate with microtubules.
Gloria, Lee, Chad J, Leugers
openaire +2 more sources
Altered synapse stability in the early stages of tauopathy [PDF]
, 2017 Synapse loss is a key feature of dementia but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that, even before any decrease in synapse density, there is abnormal turnover of cortical axonal boutons ...
J Jackson (7781468) +9 more
core +7 more sources