Results 21 to 30 of about 22,537 (257)
DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice [PDF]
Molecular NeurodegenerationBackground Pathogenic tau accumulation drives neurodegeneration in Alzheimer’s disease (AD). Enhancing the aging brain’s resilience to tau pathology would lead to novel therapeutic strategies.
Hao Chen +21 more
doaj +2 more sources
Seminars in Neurology, 2019 Tauopathies are rare neurodegenerative disorders related to microtubule-associated protein tau, which functions to stabilize microtubules. Pathological changes caused by overexpression or hyperphosphorylation of tau lead to the disengagement of tau from microtubules and accumulation of toxic intracellular inclusions.
Farwa, Ali, Keith, Josephs
openaire +2 more sources
Immunotherapy for Tauopathies [PDF]
Journal of Molecular Neuroscience, 2011 Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach.
Jiaping, Gu, Einar M, Sigurdsson
openaire +2 more sources
Tuberous sclerosis complex is associated with a novel human tauopathy [PDF]
, 2023 Tuberous sclerosis complex (TSC) is a neurogenetic disorder leading to epilepsy, developmental delay, and neurobehavioral dysfunction. The syndrome is caused by pathogenic variants in TSC1 (coding for hamartin) or TSC2 (coding for tuberin).
Ramos, Eliana M +12 more
core +1 more source
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy [PDF]
, 2009 Neurofibrillary tangles (NFTs) are associated with neuronal loss and correlate with cognitive impairment in Alzheimer disease, but how NFTs relate to neuronal death is not clear.
Carlson, George A +4 more
core +1 more source
Cellular and Molecular Life Sciences, 2007 Tau is a microtubule-associated protein predominantly expressed in nerve cells that promote microtubule assembly and microtubule stabilization. Tau is a cytosolic protein mainly present in axons and involved in anterograde axonal transport. In several neurodegenerative diseases, as for example Alzheimer's disease, tau metabolism is altered.
Hernández, Félix, Ávila, Jesús
openaire +3 more sources
Initiation and spreading of Tau pathology. is β-Amyloid the only key? [PDF]
, 2009 Neurodegenerative diseases associated with dementia affect 5-10 % of individuals over the age of 65 in the Western world and represent one of the main health-related socioeconomic burdens.
Clavaguera, Florence
core +1 more source
Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy
, 2022 Tauopathies such as Alzheimer’s disease are characterized by the accumulation of neurotoxic aggregates of tau protein. With aging and, especially, in Alzheimer’s patients, the inducible enzyme heme oxygenase 1 (HO-1) progressively increases ...
del Sastre, Eric +44 more
core +1 more source
Frontiers in Physiology, 2023 Rationale: Although sleep apnea occurs in over 50% of individuals with Alzheimer’s Disease (AD) or related tauopathies, little is known concerning the potential role of tauopathy in the pathogenesis of sleep apnea.
Alexandria B. Marciante +5 more
doaj +1 more source
Sex-Related Motor Deficits in the Tau-P301L Mouse Model
Biomedicines, 2021 The contribution of mouse models for basic and translational research at different levels is important to understand neurodegenerative diseases, including tauopathies, by studying the alterations in the corresponding mouse models in detail.
Luana Cristina Camargo +8 more
doaj +1 more source