Results 11 to 20 of about 5,518 (179)
Magnetic Resonance Imaging in Tauopathy Animal Models [PDF]
Frontiers in Aging Neuroscience, 2022 The microtubule-associated protein tau plays an important role in tauopathic diseases such as Alzheimer’s disease and primary tauopathies such as progressive supranuclear palsy and corticobasal degeneration.
Ruiqing Ni, Ruiqing Ni
doaj +2 more sources
Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and function
Aging BrainTauopathies are neurodegenerative disorders in which the pathological intracellular aggregation of the protein tau causes cognitive deficits. Additionally, clinical studies report muscle weakness in populations with tauopathy.
Bryan Alava +6 more
doaj +2 more sources
Cell ReportsSummary: Traumatic brain injury (TBI) increases one’s risk of developing Alzheimer’s disease and tauopathy. Yet, the mechanisms linking TBI to neurodegenerative disease remain poorly defined.
Ana Royo Marco +6 more
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Zebrafish models of Tauopathy [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2011 Tauopathies are a group of incurable neurodegenerative diseases, in which loss of neurons is accompanied by intracellular deposition of fibrillar material composed of hyperphosphorylated forms of the microtubule-associated protein Tau. A zebrafish model of Tauopathy could complement existing murine models by providing a platform for genetic and ...
Bai, Qing, Burton, Edward A.
openaire +3 more sources
Galectin-3 aggravates microglial activation and tau transmission in tauopathy
The Journal of Clinical InvestigationAlzheimer’s disease is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (pTau), and microglia activation.
Jian Jing Siew +21 more
doaj +2 more sources
Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy [PDF]
, 2022 Tauopathies such as Alzheimer’s disease are characterized by the accumulation of neurotoxic aggregates of tau protein. With aging and, especially, in Alzheimer’s patients, the inducible enzyme heme oxygenase 1 (HO-1) progressively increases ...
del Sastre, Eric +44 more
core +1 more source
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy [PDF]
, 2009 Neurofibrillary tangles (NFTs) are associated with neuronal loss and correlate with cognitive impairment in Alzheimer disease, but how NFTs relate to neuronal death is not clear.
Carlson, George A +4 more
core +1 more source
Initiation and spreading of Tau pathology. is β-Amyloid the only key? [PDF]
, 2009 Neurodegenerative diseases associated with dementia affect 5-10 % of individuals over the age of 65 in the Western world and represent one of the main health-related socioeconomic burdens.
Clavaguera, Florence
core +1 more source
Tuberous sclerosis complex is associated with a novel human tauopathy [PDF]
, 2023 Tuberous sclerosis complex (TSC) is a neurogenetic disorder leading to epilepsy, developmental delay, and neurobehavioral dysfunction. The syndrome is caused by pathogenic variants in TSC1 (coding for hamartin) or TSC2 (coding for tuberin).
Ramos, Eliana M +12 more
core +1 more source
Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy [PDF]
, 2021 Tauopathies are a group of more than twenty known disorders that involve progressive neurodegeneration, cognitive decline and pathological tau accumulation. Current therapeutic strategies provide only limited, late-stage symptomatic treatment.
Vandsburger, Moriel +54 more
core +1 more source