Results 11 to 20 of about 19,301 (220)
Astrocytes in Tauopathies [PDF]
Frontiers in Neurology, 2020 Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and
Matthew J. Reid +4 more
doaj +4 more sources
Immunotherapy for Tauopathies [PDF]
Journal of Molecular Neuroscience, 2011 Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach.
Jiaping, Gu, Einar M, Sigurdsson
openaire +2 more sources
Seminars in Neurology, 2019 Tauopathies are rare neurodegenerative disorders related to microtubule-associated protein tau, which functions to stabilize microtubules. Pathological changes caused by overexpression or hyperphosphorylation of tau lead to the disengagement of tau from microtubules and accumulation of toxic intracellular inclusions.
Farwa, Ali, Keith, Josephs
openaire +2 more sources
Frontiers in Neuroscience, 2023 Neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases, collectively termed tauopathy.
Naruhiko Sahara, Rin Yanai
doaj +1 more source
Frontiers in Physiology, 2023 Rationale: Although sleep apnea occurs in over 50% of individuals with Alzheimer’s Disease (AD) or related tauopathies, little is known concerning the potential role of tauopathy in the pathogenesis of sleep apnea.
Alexandria B. Marciante +5 more
doaj +1 more source
Sex-Related Motor Deficits in the Tau-P301L Mouse Model
Biomedicines, 2021 The contribution of mouse models for basic and translational research at different levels is important to understand neurodegenerative diseases, including tauopathies, by studying the alterations in the corresponding mouse models in detail.
Luana Cristina Camargo +8 more
doaj +1 more source
Neurobiology of Disease, 2012 The postoperative cognitive decline resulting from volatile anesthesia is gaining acceptance as a major health problem. The common anesthetic isoflurane is suspected to precipitate neurodegeneration in Alzheimer's disease by unknown mechanisms.
Clément Menuet +8 more
doaj +1 more source
Nature Communications, 2020 Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes
M. Catarina Silva +9 more
doaj +1 more source
Early alterations of neurovascular unit in the retina in mouse models of tauopathy
Acta Neuropathologica Communications, 2021 The retina, as the only visually accessible tissue in the central nervous system, has attracted significant attention for evaluating it as a biomarker for neurodegenerative diseases.
Fan Xia +9 more
doaj +1 more source
, 2012 Tauopathies are age-related neurodegenerative diseases that are characterized by the presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered as a microtubule-associated protein, it has been hypothesized that neurodegeneration results from a loss of the ability of tau to associate with microtubules.
Gloria, Lee, Chad J, Leugers
openaire +2 more sources