Results 11 to 20 of about 22,537 (257)

Astrocytes in Tauopathies [PDF]

Frontiers in Neurology, 2020
Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and
Matthew J. Reid, Paula Beltran-Lobo, Louisa Johnson, Beatriz Gomez Perez-Nievas, Wendy Noble   +4 more
doaj   +4 more sources

Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and function

Aging Brain
Tauopathies are neurodegenerative disorders in which the pathological intracellular aggregation of the protein tau causes cognitive deficits. Additionally, clinical studies report muscle weakness in populations with tauopathy.
Bryan Alava, Gabriela Hery, Silvana Sidhom, Miguel Gutierrez-Monreal, Stefan Prokop, Karyn A. Esser, Jose Abisambra   +6 more
doaj   +2 more sources

Therapeutic VEGFC treatment provides protection against traumatic-brain-injury-driven tauopathy pathogenesis

Cell Reports
Summary: Traumatic brain injury (TBI) increases one’s risk of developing Alzheimer’s disease and tauopathy. Yet, the mechanisms linking TBI to neurodegenerative disease remain poorly defined.
Ana Royo Marco, Katherine R. Bruch, Maureen N. Cowan, Julia G. Dill, Katelyn A. Moore, Ashley C. Bolte, John R. Lukens   +6 more
doaj   +2 more sources

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

Nature Communications, 2020
Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes
M. Catarina Silva, Ghata A. Nandi, Sharon Tentarelli, Ian K. Gurrell, Tanguy Jamier, Diane Lucente, Bradford C. Dickerson, Dean G. Brown, Nicholas J. Brandon, Stephen J. Haggarty   +9 more
doaj   +2 more sources

Emerging directions in tauopathy research. [PDF]

Alzheimers Dement
Abstract The Tau Global Conference 2025, hosted by the Alzheimer's Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of
Buée L, Wildsmith KR, Alladi S, Bertucci T, Boche D, Bowles KR, Boxer A, Brummet J, DeVos SL, Diaz K, Dreyer AJ, Duff K, Duran-Aniotz C, Durrant CS, Farrell K, Fontana IC, Franzmeier N, Frost B, Horie K, Kaňovský P, Kao AW, Mahinrad S, Malpetti M, Morris HR, Palleis C, Petrucelli L, Rexach J, Reyderman L, Rommel A, Rowe JB, Sanabria Bohórquez SM, Sato C, Schöll M, Schneider A, de Silva R, Snyder HM, VandeVrede L, Varga AW, Vogel JW, Yeh FL, Yoo AS, Carrillo MC.   +41 more
europepmc   +2 more sources

Tau positron emission tomography analysis methods for the quantification of tau spread in preclinical and early Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Inhibition of pathological tau spread may slow cognitive decline in Alzheimer's disease. Here, we evaluate two tau positron emission tomography (PET) analysis methods designed for detecting tau spread. METHODS Spatial progression of tauopathy (SPOT) and tau‐naïve anatomical region of interest (tau‐naïve ROI) methods were assessed ...
Wong J, Wang T, Datta R, Abdollahi RO, Li J, Rowe CC, Henley D, Kolb HC, Saad ZS, Alzheimer's Disease Neuroimaging Initiative.   +9 more
europepmc   +2 more sources

Loss of SMARCAD1 Mitigates Tauopathy. [PDF]

Aging Cell
Using genetics approaches in a C. elegans transgenic model of tauopathy, we uncover a role for the homolog of human SMARCAD1, a regulator of chromatin dynamics. ABSTRACT Tauopathies are neurodegenerative diseases characterized by the accumulation of misfolded tau protein and include Alzheimer's disease (AD) and related dementia disorders.
Jadhav VS, Kow RL, Beale AD, Baum M, McMillan PJ, Latimer CS, Liachko NF, Kraemer BC.   +7 more
europepmc   +2 more sources

Zebrafish models of Tauopathy

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2011
Tauopathies are a group of incurable neurodegenerative diseases, in which loss of neurons is accompanied by intracellular deposition of fibrillar material composed of hyperphosphorylated forms of the microtubule-associated protein Tau.
Edward A. Burton, Qing Bai, Burton, Edward A., Bai, Qing   +3 more
core   +3 more sources

Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy

Communications Biology
Pathological tau disrupts protein homeostasis (proteostasis) within neurons in Alzheimer’s disease (AD) and related disorders. We previously showed constitutive activation of the endoplasmic reticulum unfolded protein response (UPRER) transcription ...
Sarah M. Waldherr, Marina Han, Aleen D. Saxton, Taylor A. Vadset, Pamela J. McMillan, Jeanna M. Wheeler, Nicole F. Liachko, Brian C. Kraemer   +7 more
doaj   +2 more sources

Galectin-3 aggravates microglial activation and tau transmission in tauopathy

The Journal of Clinical Investigation
Alzheimer’s disease is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (pTau), and microglia activation.
Jian Jing Siew, Hui-Mei Chen, Feng-Lan Chiu, Chia-Wei Lee, Yao-Ming Chang, Hung-Lin Chen, Thi Ngoc Anh Nguyen, Hung-Ting Liao, Mengyu Liu, Hsiao-Tien Hagar, Yung-Chen Sun, Hsing-Lin Lai, Min-Hao Kuo, David Blum, Luc Buée, Lee-Way Jin, Shih-Yu Chen, Tai-Ming Ko, Jie-Rong Huang, Hung-Chih Kuo, Fu-Tong Liu, Yijuang Chern   +21 more
doaj   +2 more sources