Results 31 to 40 of about 5,518 (179)

Multi-organ comparison and quantification parameters of [18F]THK-5317 uptake in preclinical mouse models of tau pathology

Frontiers in Physics, 2023
Introduction: Current small-animal PET instrumentation provides sufficient resolution, sensitivity, and quantitative accurate information on the radiotracer distribution within the whole body.
Thomas Wanek, Thomas Wanek, Severin Mairinger, Severin Mairinger, Thomas Filip, Thomas Filip, Mathilde Löbsch, Mathilde Löbsch, Johann Stanek, Johann Stanek, Claudia Kuntner, Claudia Kuntner, Claudia Kuntner   +12 more
doaj   +1 more source

Astrogliopathy in Tauopathies [PDF]

Neuroglia, 2018
Astrocytes are involved in many diseases of the central nervous system, not only as reactive cells to neuronal damage but also as primary actors in the pathological process. Astrogliopathy is a term used to designate the involvement of astrocytes as key elements in the pathogenesis and pathology of diseases and injuries of the central nervous system ...
openaire   +2 more sources

Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures

Biomolecules, 2022
Tau pathology extends throughout the brain in a prion-like fashion through connected brain regions. However, the details of the underlying mechanisms are incompletely understood.
Dhwani S. Korde, Christian Humpel
doaj   +1 more source

Targeting tauopathy with engineered tau-degrading intrabodies [PDF]

, 2019
BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies.
Mann, Carolyn N, Gallardo, Gilbert, Lin, Kent H, Wong, Connie H, Ricardez, Sara M, Jiang, Hong, Holtzman, David M, Leyns, Cheryl E G   +7 more
core   +1 more source

Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.

PLoS ONE, 2013
Cell adhesion molecules are important structural substrates, required for synaptic plasticity and synaptogenesis. CAMs differ widely in their expression throughout different brain regions and their specific structural and functional roles in the brain ...
Hervé Maurin, Claire Marie Seymour, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, Mathias V Schmidt, Sebastian Kuegler, Fred Van Leuven   +8 more
doaj   +1 more source

Curcumin as a Holistic Treatment for Tau Pathology

Frontiers in Pharmacology, 2022
Global forecasts for prevalence of Alzheimer’s Disease (AD) estimate that 152.8 million people will have dementia in 2050, a sharp rise from 57.4 million in 2019 (GBD 2019).
Lovesha Sivanantharajah, Amritpal Mudher
doaj   +1 more source

Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration

Frontiers in Neuroscience, 2019
ObjectiveWhile Alzheimer’s disease is associated with inner retina thinning measured by spectral-domain optical coherence tomography (SD-OCT), our previous cross-sectional study suggested outer retina thinning in frontotemporal degeneration (FTD ...
Benjamin J. Kim, Murray Grossman, Delu Song, Samantha Saludades, Wei Pan, Sophia Dominguez-Perez, Joshua L. Dunaief, Tomas S. Aleman, Gui-Shuang Ying, David J. Irwin   +9 more
doaj   +1 more source

Clinical Spectrum of Tauopathies

Frontiers in Neurology, 2022
Tauopathies are both clinical and pathological heterogeneous disorders characterized by neuronal and/or glial accumulation of misfolded tau protein. It is now well understood that every pathologic tauopathy may present with various clinical phenotypes based on the primary site of involvement and the spread and distribution of the pathology in the ...
Nahid Olfati, Nahid Olfati, Ali Shoeibi, Irene Litvan   +3 more
openaire   +5 more sources

Autophagy gridlock in tauopathy [PDF]

, 2016
Tauopathies are a group of neurodegenerative diseases characterized by the presence of intracellular aggregates containing the microtubule associated protein tau. Bulk degradation of aggregation-prone proteins can occur via autophagy.
Bakhoum, Mathieu 1985-
core   +2 more sources

Microglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy.

, 2018
Tauopathy is characterized by the fibrillar tau accumulation in neurons and glial cells. In order to advance our understanding of the causative mechanisms of tauopathy, neuroinflammation, which has been suggested to play important roles in disease ...
864886, 864876, 864887, 864877, 864878, 864879, Sahara, Naruhiko, Ishikawa, Ai, Higuchi, Makoto, Maeda, Jun, Suhara, Tetsuya, 864880, 864881, 864882, 864883, 864884, Tokunaga, Masaki, 864885   +17 more
core   +1 more source