Results 31 to 40 of about 22,537 (257)
Brain Research Bulletin, 2016 Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly understood; current nosological concepts are largely based on these molecular signatures of protein aggregates which also provide valuable tools for neuropathological ...
Thomas, Arendt +2 more
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Early alterations of neurovascular unit in the retina in mouse models of tauopathy
Acta Neuropathologica Communications, 2021 The retina, as the only visually accessible tissue in the central nervous system, has attracted significant attention for evaluating it as a biomarker for neurodegenerative diseases.
Fan Xia +9 more
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, 2012 Tauopathies are age-related neurodegenerative diseases that are characterized by the presence of aggregates of abnormally phosphorylated tau. As tau was originally discovered as a microtubule-associated protein, it has been hypothesized that neurodegeneration results from a loss of the ability of tau to associate with microtubules.
Gloria, Lee, Chad J, Leugers
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Pneumonia initiates a tauopathy [PDF]
The FASEB Journal, 2021 Abstract Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment
Ron Balczon +15 more
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Frontiers in Physics, 2023 Introduction: Current small-animal PET instrumentation provides sufficient resolution, sensitivity, and quantitative accurate information on the radiotracer distribution within the whole body.
Thomas Wanek +12 more
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Astrogliopathy in Tauopathies [PDF]
Neuroglia, 2018 Astrocytes are involved in many diseases of the central nervous system, not only as reactive cells to neuronal damage but also as primary actors in the pathological process. Astrogliopathy is a term used to designate the involvement of astrocytes as key elements in the pathogenesis and pathology of diseases and injuries of the central nervous system ...
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Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures
Biomolecules, 2022 Tau pathology extends throughout the brain in a prion-like fashion through connected brain regions. However, the details of the underlying mechanisms are incompletely understood.
Dhwani S. Korde, Christian Humpel
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Clinical Spectrum of Tauopathies
Frontiers in Neurology, 2022 Tauopathies are both clinical and pathological heterogeneous disorders characterized by neuronal and/or glial accumulation of misfolded tau protein. It is now well understood that every pathologic tauopathy may present with various clinical phenotypes based on the primary site of involvement and the spread and distribution of the pathology in the ...
Nahid Olfati +3 more
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PLoS ONE, 2013 Cell adhesion molecules are important structural substrates, required for synaptic plasticity and synaptogenesis. CAMs differ widely in their expression throughout different brain regions and their specific structural and functional roles in the brain ...
Hervé Maurin +8 more
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Curcumin as a Holistic Treatment for Tau Pathology
Frontiers in Pharmacology, 2022 Global forecasts for prevalence of Alzheimer’s Disease (AD) estimate that 152.8 million people will have dementia in 2050, a sharp rise from 57.4 million in 2019 (GBD 2019).
Lovesha Sivanantharajah, Amritpal Mudher
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