Results 41 to 50 of about 22,537 (257)
Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy
, 2021 Tauopathies are a group of more than twenty known disorders that involve progressive neurodegeneration, cognitive decline and pathological tau accumulation. Current therapeutic strategies provide only limited, late-stage symptomatic treatment.Vandsburger, Moriel, Laping, Nicholas J, Tal Frolinger, Michelle Bell, Seyfried, Nicholas T., Chishti, Emad, Nicholas Zulia, Hamm, Matthew J., Matthew J. Hamm, Fontaine, Sarah N, Galvis-Escobar, Sara M., Di Domenico, Fabio, Frolinger, Tal, Bell, Michelle, Jennifer Rodriguez-Rivera, Zulia, Nicholas, Duong, Duc, Rodriguez-Rivera, Jennifer, Chiara Lanzillotta, Fabio Di Domenico, Koren, John, III, Shon A. Koren, Sarah N. Fontaine, Alexandria Ingram, Hamm, Matthew J, Nicholas T. Seyfried, Fontaine, Sarah N., Cloyd, Ryan, Jose F. Abisambra, Abisambra, Jose F, Powell, David K., Moriel Vandsburger, Anika M. S. Hartz, Laping, Nicholas J., Ingram, Alexandria, Ryan Cloyd, John Koren, Seyfried, Nicholas T, Hartz, Anika M S, Nicholas J. Laping, Axten, Jeffrey M., Galvis-Escobar, Sara M, Koren, John, Sara M. Galvis-Escobar, Powell, David, Koren, Shon A., Koren, Shon A, David Powell, Lanzillotta, Chiara, Hartz, Anika M. S., Emad Chishti, Jeffrey M. Axten, Duc Duong, Axten, Jeffrey M, Abisambra, Jose F. +54 morecore +1 more sourcePersistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration
Frontiers in Neuroscience, 2019 ObjectiveWhile Alzheimer’s disease is associated with inner retina thinning measured by spectral-domain optical coherence tomography (SD-OCT), our previous cross-sectional study suggested outer retina thinning in frontotemporal degeneration (FTD ...Benjamin J. Kim, Murray Grossman, Delu Song, Samantha Saludades, Wei Pan, Sophia Dominguez-Perez, Joshua L. Dunaief, Tomas S. Aleman, Gui-Shuang Ying, David J. Irwin +9 moredoaj +1 more sourcePrimary retinal tauopathy: A tauopathy with a distinct molecular pattern
Alzheimer's & Dementia, 2023 AbstractBACKGROUNDPhosphorylated tau (p‐tau) accumulation, a hallmark of Alzheimer's disease (AD), can also be found in the retina. However, it is uncertain whether it is linked to AD or another tauopathy.METHODSRetinas from 164 individuals, with and without AD, were analyzed for p‐tau accumulation and its relationship with age, dementia, and vision ...Walkiewicz, Grzegorz, Ronisz, Alicja, Van Ginderdeuren, Rita, Lemmens, Sophie, Bouwman, Femke H., Hoozemans, Jeroen J.M., Morrema, Tjado H.J., Rozemuller, Annemieke J., Hart de Ruyter, Frederique J., De Groef, Lies, Stalmans, Ingeborg, Thal, Dietmar Rudolf +11 moreopenaire +2 more sourcesAtypical astroglial pTDP-43 pathology in astroglial predominant tauopathy
, 2021 We observed atypical astrocytic pTDP-43 pathology in astroglial predominant ...Gelpi, Ellen, Abellan‐Vidal, Maria Teresa, Antonell Boixader, Anna, Ellen Gelpi, Andres-Benito, Pol, Mercadel Fañanas, Pilar, Abellan-Vidal, María Teresa, Rovelet Lecrux, Anne, Lopez‐Villegas, Dolores, Laura Molina‐Porcel, Aldecoa, Iban, Sigrid Klotz, Pol Andres‐Benito, Antonell, Anna, Molina-Porcel, Laura, López Villegas, Dolores, Maria Teresa Abellan‐Vidal, Molina‐Porcel, Laura, Gomez-Anson, Beatriz, Borrego, Sergi, Sanchez‐Valle, Raquel, Dolores Lopez‐Villegas, Sanchez-Valle, Raquel, Morenas-Rodriguez, Estrella, Klotz, Sigrid, Pilar Mercadel‐Fañanas, Anne Rovelet‐Lecrux, Beatriz Gomez‐Anson, Molina Porcel, Laura, Rovelet‐Lecrux, Anne, Andres‐Benito, Pol, Gomez‐Anson, Beatriz, Anna Antonell, Lopez-Villegas, Dolores, Sánchez Valle, Raquel, Fortea, Juan, Ribosa, Roser, Ferrer, Isidre, Raquel Sanchez‐Valle, Teresa Ximelis, Ximelis, Teresa, Rovelet-Lecrux, Anne, Gómez Anson, Beatriz, Isidre Ferrer, Juan Fortea, Iban Aldecoa, Estrella Morenas, Mercadel‐Fañanas, Pilar, Sergi Borrego, Roser Ribosa, Mercadel-Fañanas, Pilar, Andrés Benito, Pol, Borrego-Ecija, Sergi, Morenas, Estrella +53 morecore +1 more sourceDetection of cerebral tauopathy in P301L mice using high-resolution large-field multifocal illumination fluorescence microscopy [PDF]
, 2020 Current intravital microscopy techniques visualize tauopathy with high-resolution, but have a small field-of-view and depth-of-focus. Herein, we report a transcranial detection of tauopathy over the entire cortex of P301L tauopathy mice using large-field Riek, Roland,, Nilsson, Peter,, Shi, Gloria,, Razansky, Daniel,, Klohs, Jan,, Chen, Zhenyue,, Gerez, Juan A.,, Ni, Ruiqing,, Zhou, Quanyu, +8 morecore +2 more sourcesPhosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L × GSK3β mice by delaying brainstem tauopathy
Neurobiology of Disease, 2014 Tau.P301L transgenic mice suffer precocious mortality between ages 8 and 11 months, resulting from upper airway defects caused by tauopathy in autonomic brainstem circuits that control breathing (Dutschmann et al., 2010). In individual mice, the clinical Natalia Crespo-Biel, Clara Theunis, Peter Borghgraef, Benoit Lechat, Herman Devijver, Hervé Maurin, Fred Van Leuven +6 moredoaj +1 more sourceMicroglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy.
, 2018 Tauopathy is characterized by the fibrillar tau accumulation in neurons and glial cells. In order to advance our understanding of the causative mechanisms of tauopathy, neuroinflammation, which has been suggested to play important roles in disease ...864886, 864876, 864887, 864877, 864878, 864879, Sahara, Naruhiko, Ishikawa, Ai, Higuchi, Makoto, Maeda, Jun, Suhara, Tetsuya, 864880, 864881, 864882, 864883, 864884, Tokunaga, Masaki, 864885 +17 morecore +1 more sourceBrainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction
Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding +8 morewiley +1 more sourceIncreased Cerebral Level of P2X7R in a Tauopathy Mouse Model by PET Using [18F]GSK1482160. [PDF]
Neuroinflammation plays an important role in Alzheimer's disease and primary tauopathies. The aim of the current study was to map [18F]GSK1482160 for imaging of purinergic P2X7R in Alzheimer's disease and primary tauopathy mouse models.Kong, Yanyan, Zhuang, Junyi, Huang, Qi, Wang, Jiao, Rominger, Axel, Ni, Ruiqing; id_orcid, Jin, Hongjun, Rominger, Axel; https://orcid.org/, Shi, Kuangyu, Xie, Fang, Qiu, Yifan, Guan, Yihui, Ni, Ruiqing; https://orcid.org/, Ni, Ruiqing, Hou, Yuyi, Liu, Yongshan, Bi, Lei, Rominger, Axel Oliver, Shi, Kuangyu; https://orcid.org/, Yang, Yunhao, Cao, Lei +20 morecore +1 more source
