Results 61 to 70 of about 31,957 (244)

Possible Mechanisms of Tau Spread and Toxicity in Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2021
Tau is a protein that associates with microtubules (MTs) and promotes their assembly and stability. The protein loses its ability to bind MTs in tauopathies, and detached tau can misfold and induce the pathological changes that characterize Alzheimer’s ...
Huiqin Zhang, Yu Cao, Lina Ma, Yun Wei, Hao Li   +4 more
doaj   +1 more source

Label‐Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva

Advanced Materials, EarlyView.
Galvanic molecular entrapment (GME) is a label‐free method for detecting and quantifying neuroprotein conformational states. This technique enables direct surface binding and in situ hotspot generation around molecules, effectively overcoming challenges related to target localization and mismatched hotspot geometries.
Muhammad Shalahuddin Al Ja'farawy, Jun‐Yeong Yang, Chaewon Mun, Seunghun Lee, Chul Bum Cho, Yoo Hyun Um, Min‐Young Lee, Sung‐Gyu Park, Dong‐Ho Kim, Seung Ho Yang, Ho Sang Jung   +10 more
wiley   +1 more source

Tau and tauopathies

Brain Research Bulletin, 2016
Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly understood; current nosological concepts are largely based on these molecular signatures of protein aggregates which also provide valuable tools for neuropathological ...
Thomas, Arendt, Jens T, Stieler, Max, Holzer   +2 more
openaire   +2 more sources

Applications of Immunomagnetic Reduction Technology as a Biosensor in Therapeutic Evaluation of Chinese Herbal Medicine in Tauopathy Alleviation of an AD Drosophila Model

Biosensors, 2022
Alzheimer’s disease (AD) is the most common form of dementia. The most convincing biomarkers in the blood for AD are currently β-amyloid (Aβ) and Tau protein because amyloid plaques and neurofibrillary tangles are pathological hallmarks in the brains of ...
Ming-Tsan Su, Chen-Wen Lu, Wen-Jhen Wu, Yong-Sin Jheng, Shieh-Yueh Yang, Wu-Chang Chuang, Ming-Chung Lee, Chung-Hsin Wu   +7 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Dysregulation of microtubule stability impairs morphofunctional connectivity in primary neuronal networks [PDF]

, 2017
Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated.
Jacobine Kuijlaars, Jan R. Detrez, Jean-Pierre Timmermans, Marlies Verschuuren, Peter Verstraelen, Rony Nuydens, Winnok H. De Vos, Winnok H. De Vos   +7 more
core   +2 more sources

Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers

FEBS Open Bio
The deposition of highly phosphorylated and aggregated tau is a characteristic of tauopathies, including Alzheimer's disease. It has long been known that different isoforms of tau are aggregated in different cell types and brain regions in each tauopathy.
Taeko Kimura, Haruaki Sato, Maria Kano, Lisa Tatsumi, Taisuke Tomita   +4 more
doaj   +1 more source

Involvement of Glycogen Synthase Kinase 3β (GSK3β) in Formation of Phosphorylated Tau and Death of Retinal Ganglion Cells of Rats Caused by Optic Nerve Crush

Current Issues in Molecular Biology, 2023
Tauopathy is a neurodegenerative condition associated with oligomeric tau formation through abnormal phosphorylation. We previously showed that tauopathy is involved in death of retinal ganglion cells (RGCs) after optic nerve crush (ONC).
Yurie Fukiyama, Takahisa Hirokawa, Shinji Takai, Teruyo Kida, Hidehiro Oku   +4 more
doaj   +1 more source

Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Advanced Science, EarlyView.
Nanoplastics are pervasive environmental contaminants with potentially profound implications for human health. Emerging evidence suggests a possible link between nanoplastic exposure and neurodegeneration, a key driver of ageing and dementia, yet causality remains unresolved.
Yuhuan Li, Yue Wang, Xiufang Liang, Mengze Xu, David T. Leong, Pu Chun Ke   +5 more
wiley   +1 more source

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. [PDF]

, 2018
Alzheimer's disease (AD), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. Hemizygous missense variants in Triggering Receptor Expressed on
Akassoglou, Katerina, Clelland, Claire, Cooper, Yonatan A, Coppola, Giovanni, Davalos, Dimitrios, Gan, Li, Gao, Fuying, Hauduc, Axel, Kodama, Lay, Le, David, Li, Yaqiao, Ludwig, Connor, Sayed, Faten A, Telpoukhovskaia, Maria, Zhan, Lihong, Zhou, Yungui   +15 more
core   +1 more source