Results 61 to 70 of about 5,518 (179)
Communications BiologyPathological tau disrupts protein homeostasis (proteostasis) within neurons in Alzheimer’s disease (AD) and related disorders. We previously showed constitutive activation of the endoplasmic reticulum unfolded protein response (UPRER) transcription ...
Sarah M. Waldherr +7 more
doaj +1 more source
Advanced Science, EarlyView.This study establishes a universally applicable framework for vesicle surface analysis by combining engineered amyloid‐β‐displaying nanovesicles with machine‐learning‐optimized impedance spectroscopy. Equivalent‐circuit modeling reveals that membrane capacitance correlates with the surface protein states, enabling label‐free quantification of vesicle ...
Jaeyoon Song +5 more
wiley +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Hippocampal Sclerosis Dementia with Tauopathy
, 2003 In some elderly individuals with dementia, hippocampal sclerosis (HS) is the only remarkable autopsy finding. The cause of HS in this setting is puzzling, since known causes of HS such as seizures or global hypoxic-ischemic episodes are rarely present ...
Scott, Sarah +27 more
core +1 more source
Emerging roles for innate and adaptive immunity in tauopathies
Cell ReportsSummary: Tauopathies encompass a large majority of dementia diagnoses and are characterized by toxic neuronal or glial inclusions of the microtubule-associated protein tau. Tau has a high propensity to induce prion-like spreading throughout the brain via
Alexis M. Johnson, John R. Lukens
doaj +1 more source
Nature Communications, 2019 Blocking the PD-1 pathway was shown to be effective in amyloid beta mouse models, yet little is known about its therapeutic potential in models of tauopathy.
Neta Rosenzweig +11 more
doaj +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S Tau transgenic mice : a system for screening drugs against tauopathies [PDF]
, 2015 Intracellular tau aggregates are the neuropathological hallmark of several neurodegenerative diseases, including Alzheimer's disease, progressive supranuclear palsy, and cases of frontotemporal dementia, but the link between these aggregates and ...
Horne, Graeme +10 more
core +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
TDP-43 dysfunction facilitates the pathological conversion of tau
Molecular NeurodegenerationTDP-43 proteinopathy coexists with tauopathy in a variety of neurodegenerative disorders, including Alzheimer’s Disease (AD) and AD related dementia (ADRD).
Meghraj S. Baghel +13 more
doaj +1 more source