Results 81 to 90 of about 5,518 (179)

Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains

Frontiers in Pharmacology, 2018
Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1-/- mouse ...
Taiki Shimizu, Kenta Kanai, Yui Sugawara, Chiyoko Uchida, Takafumi Uchida   +4 more
doaj   +1 more source

Lewy Body Disease Across Aging: Clinical and Neuropathological Correlates in a Population Brain Bank

Movement Disorders, EarlyView.
Abstract Background Lewy body disease (LBD) is defined by neuronal α‐synuclein pathology, but how Braak‐staged LBD relates to mixed neuropathology and clinical manifestations within a single population‐based cohort remains incompletely characterized. This is especially relevant in cohorts enriched for younger individuals, which may better inform real ...
Vitor Ribeiro Paes, Felipe Luiz Pereira, Caroline Matos Silva, Filipe Oto Cunha de Moraes, Inês Liguori Padrão, Alberto Fernando Oliveira Justo, Roberta Diehl Rodriguez, Michel Satya Naslavsky, Renata Elaine Paraizo Leite, Carlos Augusto Gonçalves Pasqualucci, Mayana Zatz, Eduardo Ferriolli, Claudia Kimie Suemoto, Lea Tenenholz Grinberg   +13 more
wiley   +1 more source

DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice

Molecular Neurodegeneration
Background Pathogenic tau accumulation drives neurodegeneration in Alzheimer’s disease (AD). Enhancing the aging brain’s resilience to tau pathology would lead to novel therapeutic strategies.
Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Jingjie Zhu, Nessa Foxe, Winston Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Tark Patel, Sue-Ann Mok, Won-min Song, Bin Zhang, Shiaoching Gong, Qin Ma, Hongjun Fu, Li Gan, Wenjie Luo   +21 more
doaj   +1 more source

Globular Glial Tauopathy Type I Presenting as Atypical Progressive Aphasia, With Comorbid Limbic-Predominant Age-Related TDP-43 Encephalopathy

Frontiers in Aging Neuroscience, 2019
Globular glial tauopathies (GGTs) have heterogeneous presentations with little available information regarding typical clinical manifestations. We report on a case of atypical primary progressive aphasia (PPA) due to comorbid GGT and limbic transactive ...
Robert Rusina, Robert Rusina, Zsolt Csefalvay, Gabor G. Kovacs, Gabor G. Kovacs, Gabor G. Kovacs, Jiri Keller, Jiri Keller, Alena Javurkova, Alena Javurkova, Radoslav Matej, Radoslav Matej   +11 more
doaj   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Defining patient\u2010centered amyloid PET thresholds for the onset of tauopathy in Alzheimer's disease

INTRODUCTION: Amyloid-induced tauopathy drives clinical decline in Alzheimer's disease (AD). Because age and sex shape tau trajectories, defining patient-centered amyloid thresholds for tauopathy onset could facilitate pre-tauopathy AD identification and
Biel, Davina, Zhu, Zeyu, Steward, Anna, Sch\uf6ll, Michael, Ossenkoppele, Rik, Gn\uf6rich, Johannes, Franzmeier, Nicolai, Xie, Fang, Höglinger, Günter, Klonowski, Madleen, Roemer\u2010Cassiano, Sebastian N., Hirsch, Fabian, Dewenter, Anna, Roemer-Cassiano, Sebastian N., Schöll, Michael, Buckley, Rachel, Pescoller, Julia, Guo, Tengfei, Shcherbinin, Sergey, H\uf6glinger, G\ufcnter, Brendel, Matthias, Alzheimer's Disease Neuroimaging Initiative (ADNI), Frontzkowski, Lukas, Gnörich, Johannes, Pontecorvo, Michael J., Dehsarvi, Amir   +25 more
core   +1 more source

Caenorhabditis elegans models of tauopathy

, 2017
One of the hallmarks of the tauopathies, which include the neurodegenerative disorders, such as Alzheimer disease (AD), corticobasal degeneration, frontotemporal dementia, and progressive supranuclear palsy (PSP), is the abnormal accumulation of post ...
Ghulam Jeelani Pir, Choudhary, B., Eckhard Mandelkow, Bikash Choudhary, Mandelkow, E., Pir, G.   +5 more
core   +1 more source

Abnormal Lipid Metabolism in Tauopathy Brains: Dysregulation and Intervention [PDF]

Dysregulation of lipid metabolism is implicated in neurodegenerative diseases like Alzheimer's disease (AD). Lipid droplets (LDs) are dynamic organelles essential for cellular lipid metabolism and homeostasis.
Nie, Yuhang
core   +1 more source

Role of FK506 binding protein 51 in central nervous system diseases

Frontiers in Molecular Neuroscience
FK506-binding protein 51 (FKBP51) is a pivotal molecular chaperone and scaffolding protein that integrates and modulates multiple signaling pathways—including those involving HSP90, the glucocorticoid receptor, AKT, and NF-κB—through its FK1, FK2, and ...
Haokun Peng, Yanhao Wei, Yanmei Qiu, Rentang Bi, Longhai Zeng, Bo Hu, Yanan Li   +6 more
doaj   +1 more source

Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death

Frontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by cognitive impairment and memory loss. Amyloid β1-42 (Aβ) and hyper-phosphorylation of microtubule-associated protein tau have been considered as major histological features in AD.
Ki Hoon Lee, Sei-Jung Lee, Hyun Jik Lee, Gee Euhn Choi, Young Hyun Jung, Dah Ihm Kim, Amr Ahmed Gabr, Amr Ahmed Gabr, Jung Min Ryu, Ho Jae Han   +9 more
doaj   +1 more source