Results 81 to 90 of about 22,537 (257)

Cognition in menopausal women

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Cognitive health in postmenopausal women is significantly affected by hormonal shifts, especially the drop in estrogen levels. This review explores the intricate relationship between menopause and cognitive functions across six domains: perception, attention, memory, language, executive functioning, and motor skills.
Suvarna Khadilkar, Jharna Mahajan (Bhanushali), Anuradha P. Mahto, Satish Khadilkar   +3 more
wiley   +1 more source

The reverse transcriptase inhibitor 3TC modulates hippocampal transcriptome signatures of inflammation in tauopathy model mice

Experimental Gerontology
Reducing neuroinflammation, a key contributor to brain aging and neurodegenerative diseases, is a promising strategy for improving cognitive function in these settings. The FDA-approved nucleoside reverse transcriptase inhibitor 3TC (Lamivudine) has been
Devin Wahl, Randy A. Grant, Thomas J. LaRocca   +2 more
doaj   +1 more source

Evaluation of Aging and Genetic Mutation Variants on Tauopathy

, 2020
Alzheimer’s disease (AD) is characterized by amyloid β plaques and neurofibrillary tau tangles (NFTs). While research has demonstrated amyloid pathology occurs prior to tau pathology, or tauopathy, tau has proven to be more toxic. Tauopathy is associated
Tetlow, Amber M.
core  

Voice and Speech in Atypical Parkinsonian Disorders

Movement Disorders Clinical Practice, EarlyView.
Background Motor speech disorders are early, common, and functionally limiting features of atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA). These impairments are underrecognized and undertreated in neurology clinics.
Federico Rodriguez‐Porcel, Farwa Ali, Michiko Bruno, Heather Davis Cuevas, Rohit Dhall, Kylie Dunne‐Platero, Lawrence I. Golbe, Ihtsham Haq, Nicole Herndon, Lawrence S. Honig, Kyurim Kang, Sarah Kremen, Guillaume Lamotte, Nikolaus R. McFarland, Michela Mir, Leila Montaser‐Kouhsari, Alexander Pantelyat, Joel Page, Hylan Pickett, Laura Purcell Verdun, Kelly Richardson, Jessica Shurer, Michelle Troche, Rene L. Utianski, Katya Villarreal‐Cavazos, Tuhin Virmani, Anne‐Marie Wills, as the Diagnosis and Treatment Working Group, CurePSP Center of Care (CoC) Network, Farwa Ali, Michiko Bruno, Timothy Chang, Rohit Dhall, Kimiko Domoto‐Reilly, Lawrence I. Golbe, Ihtsham Haq, Lawrence S. Honig, Sarah Kremen, Guillaume Lamotte, Zoltan Mari, Nikolaus R. McFarland, Leila Montaser‐Kouhsari, Alexander Pantelyat, Federico Rodriguez‐Porcel, Junaid Siddiqui, Jessica Shurer, Christopher Spears, Tuhin Virmani, Anne‐Marie Wills   +48 more
wiley   +1 more source

Progressive Supranuclear Palsy in India: Insights from a Large Multicenter Clinical Cohort (Project PAIR‐PSP)

Movement Disorders Clinical Practice, EarlyView.
Background Progressive supranuclear palsy (PSP) is a rare and devastating tauopathy with limited global data. Given India's large population, genetic diversity, and clinical heterogeneity, large multicenter datasets are crucial to enrich global understanding of PSP. Objective To characterize the demographic, clinical, and phenotypic profiles of a large
Prashanth Lingappa Kukkle, Divyani Garg, Jacky Ganguly, Soaham Desai, Rukmini Mridula Kandadai, Sahil Mehta, Pettarusp Murzban Wadia, Deepika Joshi, Lulup Sahoo, Vijayashankar Paramanandam, Taallapalli Ashok Vardhan Reddy, Adreesh Mukherjee, Syam Krishnan, Kuldeep Shetty, Charulata Sankhla, Pankaj Agarwal, Heli S. Shah, Suvorit Bhowmick, Mitesh Chandarana, Malini Venkata, Thenral S. Geetha, Ramesh Menon, Sandeep Charugulla, Sakthivel Murugan, Ravi Gupta, Niraj Kumar, Atanu Biswas, Hrishikesh Kumar, Rupam Borgohain, Huw Morris, Vedam. L Ramprasad, Parkinson's Research Alliance of India (PRAI) and the Global Parkinson's Genetic Program (GP2)   +31 more
wiley   +1 more source

The Link Between Tau and Insulin Signaling: Implications for Alzheimer’s Disease and Other Tauopathies

Frontiers in Cellular Neuroscience, 2019
The microtubule-associated protein tau (MAPT) is mainly identified as a tubulin binding protein essential for microtubule dynamics and assembly and for neurite outgrowth.
Rafaella Araujo Gonçalves, Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E. Fraser, Paul E. Fraser, Fernanda G. De Felice, Fernanda G. De Felice, Fernanda G. De Felice   +7 more
doaj   +1 more source

siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice [PDF]

, 2019
Tauopathy is a pathological hallmark of many neurodegenerative diseases. It is characterized by abnormal aggregates of pathological phosphotau and somatodendritic redistribution.
Magdy, Khaled, El-Khodery, Sabry A., Mohamed, Wael Mohamed Yousef, El-Hussiny, Mahmoud, Shabka, Osama, Youssef, Mohamed A., Alsayed, Aziza, Sobh, Mohamed, Salama, Mohamed M., Fekry, Emad, El-Desouky, Sara   +10 more
core   +1 more source

Natural Killer Subset Changes and Vascular Endothelial Growth Factor‐A Plasma Profile in Progressive Supranuclear Palsy: The NKscape Study

Movement Disorders, EarlyView.
Abstract Background Emerging evidence implicates neuroinflammation in progressive supranuclear palsy (PSP) pathophysiology, with elevated cyto‐chemokines suggesting natural killer (NK) cell involvement. Methods We characterized peripheral NK in PSP (N = 11) versus Parkinson's disease (PD, N = 10) and healthy controls (HC, N = 8) at both ...
Marina Picillo, Cristina Basile, Francesco Montella, Valentina Lopardo, Mariangela Orlando, Roberta Tarallo, Domenico Palumbo, Viola Melone, Maria Francesca Tepedino, Paolo Barone, Annibale Alessandro Puca, Elena Ciaglia   +11 more
wiley   +1 more source

Prolyl Isomerase Pin1 Directly Regulates Calcium/Calmodulin-Dependent Protein Kinase II Activity in Mouse Brains

Frontiers in Pharmacology, 2018
Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1-/- mouse ...
Taiki Shimizu, Kenta Kanai, Yui Sugawara, Chiyoko Uchida, Takafumi Uchida   +4 more
doaj   +1 more source

A Brainstem Radiomics Framework to Distinguish Progressive Supranuclear Palsy from Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Differentiating progressive supranuclear palsy (PSP) from Parkinson's disease (PD) can be clinically challenging. In the neuroimaging field, radiomics has emerged as a promising approach to capture subtle microstructural and textural image alterations, improving differential diagnoses.
Chiara Camastra, Jolanda Buonocore, Antonio Augimeri, Camilla Calomino, Maria Giovanna Bianco, Alessia Sarica, Pier Paolo Arcuri, Aldo Quattrone, Andrea Quattrone   +8 more
wiley   +1 more source