Results 101 to 110 of about 22,537 (257)
Heritability in frontotemporal tauopathies
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019 AbstractIntroductionExploring the degree of heritability in a large cohort of frontotemporal lobar degeneration with tau‐immunopositive inclusions (FTLD‐tau) and determining if different FTLD‐tau subtypes are associated with stronger heritability will provide important insight into disease pathogenesis.MethodsUsing modified Goldman pedigree ...
Shelley L. Forrest +9 more
openaire +3 more sources
Brain Pathology, EarlyView.We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour +10 more
wiley +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Research Results in PharmacologyIntroduction: Neurodegenerative diseases affecting neurons represent a wide spectrum of pathological conditions. To slow the accumulation of pathological tau protein, therapeutic interventions such as a pharmaceutical composition consisting of the ...
Veronika S. Shmigerova +11 more
doaj +1 more source
Neurodegenerative tauopathy in the worm [PDF]
Proceedings of the National Academy of Sciences, 2003 The most common neurodegenerative diseases are characterized by the presence of abnormal filamentous protein inclusions in nerve cells of the brain. In Alzheimer's disease, these inclusions are made of hyperphosphorylated tau protein (1). Together with the extracellular β-amyloid deposits, they constitute the defining neuropathological characteristics ...
openaire +2 more sources
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract INTRODUCTION Pathological tau aggregates are key therapeutic targets in Alzheimer's disease (AD), but current approaches face limitations including poor intracellular penetration, lack of selectivity for aggregated over physiological tau, or reliance on invasive administration.
Nicolas Preitner +19 more
wiley +1 more source
White matter tauopathy: Transient functional loss and novel myelin remodeling [PDF]
, 2018 Early white matter (WM) changes are common in dementia and may contribute to functional decline. We here examine this phenomenon in an induced dementia model for the first time.
Cowan, K +20 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract INTRODUCTION Recent epidemiological datasets have associated viral encephalitis exposure (i.e., viral‐induced neuroinflammation) with increased risk of Alzheimer's disease (AD) and dementia, highlighting the need to uncover how it may impact AD neuropathology.
Dominic Ibarra Javonillo +10 more
wiley +1 more source
Progress in Neurobiology, 2019 Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative diseases defined by cytoplasmic inclusions predominantly composed of tau protein isoforms with four microtubule-binding domains.
Roesler, Thomas W. +17 more
openaire +4 more sources
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, Volume 36, Issue 4, July 2026.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source