Results 101 to 110 of about 19,301 (220)

Astrocytes from P301S Tau mice exhibit non-canonical protein secretion and reduced morphological complexity

Neural Regeneration Research
Astrocytes have important neurosupportive functions in the brain that are altered in neurodegenerative diseases by unresolved mechanisms. We showed previously that astrocytes cultured from mice transgenic for human P301S-tau (P301S-mice) recapitulate the
Aishwarya G. Nadadhur, Matthew Mason, Johanna S. Rees, Marta Sidoryk-Wegrzynowicz, Aviva M. Tolkovsky, Maria Grazia Spillantini   +5 more
doaj   +1 more source

Epigenetic Mechanisms Underlying Cognitive Dysfunction in Parkinson's Disease: Current Evidence and Future Prospects

Brain and Behavior, Volume 16, Issue 8, August 2026.
Epigenetic mechanismsincluding DNA methylation, histone modifications, and microRNA (miRNA) regulationmodulate gene expression without altering the DNA sequence and are increasingly implicated in the cognitive impairment associated with Parkinson's disease (PD). Environmental and molecular factors influence these epigenetic pathways, leading to altered
Fatemeh Hasani, Mohammad Ebrahim Kherad, Mohammad Sharifi Sarasyabi, Kimia Jazi, Ali Ashkbari, Payam Ahmadi, Hadise Heidarpour, Mahdi Masrour, Sina Khamaki, Rahem Rahmati, Andrei Surguchov   +10 more
wiley   +1 more source

Emerging Trends and Hot Spots in Tauopathy Research (2003–2025): A Bibliometric Analysis

Brain and Behavior, Volume 16, Issue 8, August 2026.
This bibliometric analysis systematically evaluated global research trends in tauopathy from 2003 to 2025. Using bibliometric methods, including R package bibliometrix, VOSviewer, and Scimago Graphica, we identified publication trends, influential countries, institutions, authors, journals, and emerging research themes.
Si‐Yao Zhang, Hui‐Jie Ren, Hao‐Yu Liu, Shu‐Ying Xu, Yong‐Jun Peng   +4 more
wiley   +1 more source

Chronic Smoking Impairs Glymphatic Transport and Cognitive Function in Adolescent Mice Through Cardiac, Vascular, and Perivascular Aquaporin‐4 Mechanisms

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Chronic smoking during adolescence impairs glymphatic transport, leading to cognitive decline and aberrant accumulation of phosphorylated tau in the hippocampal DG region. Smoking‐induced glymphatic dysfunction compromises synaptogenesis and neurogenesis in the hippocampal DG region.
Chuanxiang Lv, Chengyu Xia, Zean Li, Tao Liu, Zhuang Sha, Shiying Dong, Yu Qian, Mingqi Liu, Kang Zhang, Xinran Zhang, Rongcai Jiang, Li Bie   +11 more
wiley   +1 more source

A Novel Nogo‐A Receptor Antagonist Peptide Impedes Alzheimer's Disease Pathology by Nogo‐A/NgR/ROCK Signaling Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
NAP2, a NgR1 antagonist peptide, improved cognition in APP/PS1 mice, reduced Aβ plaques and tau hyperphosphorylation, increased dendritic spine density, and alleviated mitochondrial damage, acting through inhibition of the Nogo‐A/NgR/ROCK pathway, highlighting its therapeutic potential for Alzheimer's disease.
Zheng Zhang, Huimin Tan, Fang Shi, Jiajia Dai, Weilong Ding, Junliang Li, Yuke Wang, Rui Yang, Xinke Xu, Cheng Chen, Fei Xiao, Li‐an Huang, Xiaoyan Liu, Rui Liao, Li Yan   +14 more
wiley   +1 more source

Multimodel Diffusion MRI Signatures in Atypical Parkinsonian Disorders

Human Brain Mapping, Volume 47, Issue 11, 01 August 2026.
We implemented a diffusion MRI framework to analyze clinically compatible multishell data across 123 participants, including controls, Parkinson's disease (PD), corticobasal syndrome (CBS), and progressive supranuclear palsy Richardson's syndrome (PSP‐RS). Diffusion models included DTI, free‐water elimination (FWE), NODDI, and fixel‐based analysis (FBA)
Yuqi Tian, Farwa Ali, Mary M. Machulda, Val. J. Lowe, Keith A. Josephs, Jennifer L. Whitwell   +5 more
wiley   +1 more source

Diagnostic Performance of the AlzoSure Predict Assay and Its Association With Alzheimer's Disease Biomarkers and Imaging Findings

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Early diagnosis of Alzheimer's disease (AD) is critical for improving patient outcomes. The laboratory‐developed blood test of AlzoSure measures the unfolded conformational variant of p53 (U‐p53AZ) in plasma and has shown promise as a screening tool for AD risk.
Ali Rajabpour‐Sanati, Hamide Nasiri, Farbod Khosravi, Farhang Ghahrieh, Alireza Asemanrafat, Alireza Keshavarz Bahaqiqat, Parsa Saberian, Rozhin Bakhshi, Faranak Rastegari, Ramin Ahangar‐Sirous, Amirmohammad Shahidzadehasadi, Hadis Seif, Maryam Ghahremani, Faeze Gandomi‐Nasrabadi, Zahra Azizan, Mahsa Mayeli, for the Alzheimer's Disease Neuroimaging Initiative*   +16 more
wiley   +1 more source

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Drug Design, Development and Therapy, 2016
Kuo-Hsuan Chang,1,* I-Cheng Chen,1,* Hsuan-Yuan Lin,2 Hsuan-Chiang Chen,2 Chih-Hsin Lin,1 Te-Hsien Lin,2 Yu-Ting Weng,1 Chih-Ying Chao,1 Yih-Ru Wu,1 Jung-Yaw Lin,2 Guey-Jen Lee-Chen,2 Chiung-Mei Chen1 1Department of Neurology, Chang Gung Memorial ...
Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM   +11 more
doaj  

Refining our understanding of sleep impairment and connection to Alzheimer's disease in preclinical models

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Darcy Wear, Christopher D Morrone, Wai Haung Yu   +2 more
wiley   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm, Volume 7, Issue 8, August 2026.
The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
wiley   +1 more source