Results 101 to 110 of about 5,518 (179)

Perspectives from Alzheimer's Disease Research Centers site directors on the early steps and the lasting impact

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Since the groundbreaking work of Alois Alzheimer in the early 1900s, Alzheimer's disease research has evolved immensely, most notably with the establishment of the Alzheimer's Disease Research Centers (ADRC). Fueled by the vision and funding of the National Institute on Aging (NIA), ADRCs have created a legacy through their work standardizing ...
John H. Growdon, John C. Morris, Ronald C. Petersen, Mary Sano, Lon S. Schneider   +4 more
wiley   +1 more source

siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice [PDF]

, 2019
Tauopathy is a pathological hallmark of many neurodegenerative diseases. It is characterized by abnormal aggregates of pathological phosphotau and somatodendritic redistribution.
Magdy, Khaled, El-Khodery, Sabry A., Mohamed, Wael Mohamed Yousef, El-Hussiny, Mahmoud, Shabka, Osama, Youssef, Mohamed A., Alsayed, Aziza, Sobh, Mohamed, Salama, Mohamed M., Fekry, Emad, El-Desouky, Sara   +10 more
core   +1 more source

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau‐PET.
Isabella Bizzi, Arthur C. Macedo, Lydia Trudel, Joseph Therriault, Nesrine Rahmouni, Firoza Z. Lussier, Cécile Tissot, Gleb Bezgin, Étienne Aumont, Tevy Chan, Seyyed Ali Hosseini, Delphine Oliva‐Lopez, Marina Pereira Gonçalves, Guilherme Povala, Pamela C. L. Ferreira, Bruna Bellaver, Livia Amaral, Emma Ruppert, Marina Scop Medeiros, Rayan Mroué, Andréia Rocha, Kok Pin Ng, Eduardo R. Zimmer, Joseph Masdeu, Belen Pascual, Val J. Lowe, Hwamee Oh, David N. Soleimani‐Meigooni, Juan Fortea, Zahinoor Ismail, Suzanne Baker, Tharick A Pascoal, Pedro Rosa‐Neto, for the HEAD Study, Cristiano S Aguzzoli, Livia Amaral, Guilherme Bauer‐Negrini, Bruna Bellaver, Ann D Cohen, Alvaro de Oliveira Franco, Douglas T Leffa, Pamela C L Ferreira, Firoza Z Lussier, Marina S Medeiros, Rayan Mroué, Markley S Oliveira, Tharick A Pascoal, Guilherme Povala, Andréia Rocha, Matheus S Rodrigues, Emma Ruppert, Pampa Saha, Juli Singer, Carolina Soares, Dana L Tudorascu, Raphael L Tuma, Suzanne L Baker, Cécile Tissot, Hsin‐Yeh Tsai, Pedro Rosa‐Neto, Tevy Chan, Vladimir Fonov, Yasser Iturria‐Medina, Wan Lu Jia, Jesse Klostranec, Maxime Montembault, Nesrine Rahmouni, Jenna Stevenson, Karine Provost, Paolo Vitali, Selma Avdagic, Emerine Cummings, Brian A Gordon, Danielle Gray, Victoria Tate, Joseph C Masdeu, Belen Pascual, Hwamee Oh, Xiaoyang Hu, Val Lowe, David N Soleimani‐Meigooni, Juan Fortea, Arthur Toga, Tatiana Foroud   +83 more
wiley   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, Volume 100, Issue 4, Page 709-736, October 2026.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Discovery and characterization of stereodefined PMO-gapmers targeting tau

Molecular Therapy: Nucleic Acids
Antisense oligonucleotides (ASOs) are an important class of therapeutics to treat genetic diseases, and expansion of this modality to neurodegenerative disorders has been an active area of research.
Kunihiko Kanatsu, Yoshinori Takahashi, Tetsuya Sakaguchi, Dae-Shik Kim, Miki Murota, Mingde Shan, Kazuki Fukami, Wataru Itano, Kenji Kikuta, Hikaru Yoshimura, Toshiki Kurokawa, Yuko Nagayama, Rena Ishikawa, Ryo Dairiki, Zhi Zhou, Kristen Sanders, Jacob Stupalski, So Yasui, Diana Liu, Farid Benayoud, Hui Fang, Enxuan Jing, Makoto Ogo, Francis G. Fang, John Wang, Hyeong-wook Choi   +25 more
doaj   +1 more source

Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease

BioEssays, Volume 48, Issue 10, October 2026.
Recent human genetic studies highlight the critical role of microglial pathways in Alzheimer's disease, with risk loci enriched in microglia‐specific genes such as SPI1 and MEF2C. Dysregulation of these transcription factors contributes to disease pathogenesis.
Byungwook Kim, Selena S. Wang, Justin R. Kim, Jungsu Kim   +3 more
wiley   +1 more source

The silent consequence of overdose: The case for brain injury‐informed opioid treatment

Addiction, EarlyView.
Nathaniel Day, Kym Kaufmann, Mauricio Garcia‐Barrera, Jitender Sareen, Daniel Vigo   +4 more
wiley   +1 more source

Quantifying the Diamagnetic and Paramagnetic Components of Beta‐Amyloid Plaques Using Decomposed Quantitative Susceptibility Mapping in Mouse Models of Alzheimer's Disease

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Ex vivo MRI was performed on AD mouse models using high‐resolution multi‐echo gradient‐echo imaging on a 9.4T scanner to generate quantitative susceptibility maps (QSM) and separate diamagnetic and paramagnetic components. Amyloid‐β$$ \beta $$ plaques were detected from the susceptibility maps.
Juan Liu, Jingjia Chen, Season K. Wyatt‐Johnson, Jie Chen, Zhuoheng Liu, Hongbo Wu, Li Feng, Randy R. Brutkiewicz, Nian Wang   +8 more
wiley   +1 more source

cis p-tau: early driver of brain injury and tauopathy blocked by antibody

, 2016
Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the best known environmental risk factors for chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD), whose defining pathologic features include ...
Yao, Yandan, Driver, Jane, Huang, Pengyu, Luo, Man-Li, Ryo, Akihide, Goldstein, Lee E, Lin, Yu-Min, Rotenberg, Alexander, Moncaster, Juliet, Sun, Yan, Pascual-Leone, Alvaro, Meehan, William, McKee, Ann C., Lu, Kun Ping, Qiu, Jianhua, Shahpasand, Koorosh, Wei, Shuo, Kondo, Asami, Albayram, Onder, Zhou, Xiao, Mannix, Rebekah, Chen, Chun-Hau   +21 more
core   +1 more source

Function within disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation

Protein Science, Volume 35, Issue 10, October 2026.
Abstract In numerous neurodegenerative diseases known collectively as tauopathies, the microtubule‐associated protein tau forms fibrillar aggregates that are hallmarks of disease pathology. Tauopathies represent a substantial fraction of diseases associated with protein misfolding.
Mia Cervantes, Maria K. Janowska, Lisa M. Tuttle, Miklos Guttman, Abhinav Nath, Rachel E. Klevit   +5 more
wiley   +1 more source