Results 111 to 120 of about 31,957 (244)

Understanding the Phenotypic Heterogeneity Within the Sporadic Creutzfeldt–Jakob Disease MV1 Subtype

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
We present the clinical, pathological and prion biophysical features of three atypical cases of the MV1 subtype of sporadic Creutzfeldt–Jakob disease (sCJD). We propose that these heterozygous cases exist on a spectrum ranging from MM1‐like to VV1‐like phenotypes and recommend that subtyping be performed at pH 6.9 to avoid missing atypical or mixed ...
Satish K. Nemani, Leonardo M. Cortez, Jennifer Myskiw, Ignazio Cali, Stephanie A. Booth, Gerard H. Jansen, Valerie L. Sim   +6 more
wiley   +1 more source

Tau promotes neurodegeneration through global chromatin relaxation [PDF]

, 2014
The microtubule-associated protein tau is involved in a number of neurodegenerative disorders, including Alzheimer’s disease (AD). Previous studies link oxidative stress and subsequent DNA damage to neuronal death in AD and related tauopathies. Since DNA
Feany, Mel B., Frost, Bess, Hemberg, Martin, Lewis, Jada   +3 more
core   +1 more source

Identification of Alzheimer's disease subtypes and biomarkers from human multi‐omics data using subspace merging algorithm

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS We applied a subspace‐merging algorithm to integrate multi‐omics data from brain tissues
Ziyan Song, Xiaoqing Huang, Asha Jacob Jannu, Travis S. Johnson, Jie Zhang, Kun Huang   +5 more
wiley   +1 more source

Atypical parkinsonism: An Update. [PDF]

, 2013
Purpose of review: This update discusses novel aspects on genetics, diagnosis, and treatments of atypical parkinsonism published over the past 2 years. Recent findings: A genome-wide association study identified new genetic risk factors for progressive ...
Hoeglinger, GU, Stamelou, M
core   +1 more source

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy. [PDF]

, 2019
ObjectiveTo characterize individual and group-level neuroimaging findings in patients at risk for Chronic Traumatic Encephalopathy (CTE).MethodsEleven male patients meeting criteria for Traumatic Encephalopathy Syndrome (TES, median age: 64) underwent ...
Baker, Suzanne L, Bourakova, Viktoriya, Chaudhary, Kiran, Edwards, Lauren, Gardner, Raquel C, Jagust, William J, Janabi, Mustafa, Kramer, Joel H, La Joie, Renaud, Lesman-Segev, Orit H, Miller, Bruce L, O'Neil, James P, Perry, David C, Rabinovici, Gil D, Sonni, Ida, Stephens, Melanie L, Tsai, Richard, Visani, Adrienne V   +17 more
core  

Investigation of the pharmacological activity of the tetrapeptide HAEЕ, zinc, and human serum albumin in a transgenic mouse model with tau protein overexpression (P301S)

Research Results in Pharmacology
Introduction: Neurodegenerative diseases affecting neurons represent a wide spectrum of pathological conditions. To slow the accumulation of pathological tau protein, therapeutic interventions such as a pharmaceutical composition consisting of the ...
Veronika S. Shmigerova, Yulia V. Stepenko, Alexandra A. Kurbatova, Nikita S. Zhunusov, Nikita S. Lyapkalov, Maria S. Sviridova, Tatyana V. Avtina, Arkadiy V. Nesterov, Alexander A. Popov, Natalia I. Nesterova, Mariia Iu. Goltsova, Tatiana G. Pokrovskaya   +11 more
doaj   +1 more source

circPDE4B downregulation triggers GEMIN5‑dependent translational stress response and autophagy to reduce MAPT pathology

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri, Sophie J. F. van der Spek, Mintao Lin, Zihan Wang, Jacob Porter, Junming Hu, Liyuan Hu, Alejandro N. Rondón‐Ortiz, Alexander Knyshov, Jenna L. Libera, Scott E. Counts, Debomoy K. Lahiri, Julia TCW, Andrew Emili, Xiaoling Zhang, Benjamin Wolozin   +15 more
wiley   +1 more source

Tauopathies, motricité et cognition [Tauopathy, motricity and cognition]

, 2023
The tauopathies are one of the families of proteinopathies causing neurodegenerative diseases. They are characterized by a combination of cognitive and motor disorders. In this article, we summarize the clinical features of progressive supranuclear palsy and cortico-basal degeneration, focusing on their cognitive-behavioral impairment profiles, which ...
Kermorvant, H., Castro-Jimenez, M., Allali, G., Bally, J.F.   +3 more
openaire   +1 more source

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, Volume 99, Issue 5, Page 1343-1353, May 2026.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source