Results 111 to 120 of about 5,518 (179)

Modulation of neuroinflammation and tauopathy by RNA-binding protein TIA1 in the P301S mouse model of tauopathy [PDF]

, 2020
Tauopathies are a class of neurodegenerative diseases characterized by aggregation of hyperphosphorylated microtubule associated protein tau (phospho-tau), resulting in neuroinflammation and neurodegeneration. Neuroinflammatory processes play an integral
LeBlang, Chelsey Jenna
core  

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

Tauopathy in the young autistic brain: novel biomarker and therapeutic target

, 2020
: Given our recent discovery of somatic mutations in autism spectrum disorder (ASD)/intellectual disability (ID) genes in postmortem aged Alzheimer's disease brains correlating with increasing tauopathy, it is important to decipher if tauopathy is ...
Marusic, Zlatko, Hait, Tom Aharon, Vukovic, Jurica, Grigg, Iris, Grigoriadis, Nikolaos, Van Dijck, Anke, Lagoudaki, Roza, Touloumi, Olga, Ivashko-Pachima, Yanina, Anicic, Mirna, Korenkova, Vlasta, Gozes, Illana, Kooy, Frank   +12 more
core  

Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer’s-like Tauopathy Mouse Model

Cells
Basal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of Alzheimer’s disease (AD). Recent evidence suggests that tau protein is a putative target for the treatment of dementia, and the tau ...
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R. Harrington, Claude M. Wischik, Gernot Riedel, Grazyna Niewiadomska   +7 more
doaj   +1 more source

Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model

, 2017
Tauopathy comprises a group of disorders caused by abnormal aggregates of tau protein. In these disorders phosphorylated tau protein tends to accumulate inside neuronal cells (soma) instead of the normal axonal distribution of tau.
Magdy, Alshimaa, Mohamed, Wael Mohamed Yousef, Mohamed Salama, Ahmed G. Omran, Omran, Ahmed G., Elhussiny, Mahmoud, Aziza Alsayed, Alshimaa Magdy, Ramy Ashry, Wael Mohamed, Salama, Mohamed, Alsayed, Aziza, Mahmoud Elhussiny, Ashry, Ramy   +13 more
core   +1 more source

Implications of mitochondrial phosphatidylethanolamine in neuronal health and neurodegeneration

Neural Regeneration Research
Phosphatidylethanolamine is a major phospholipid class abundant in the brain, particularly in the inner leaflet of the plasma and mitochondrial membranes. Although it is primarily synthesized from phosphatidylserine via decarboxylation in mitochondria or
Yantao Zuo, Niharika Amireddy, Qian Cai
doaj   +1 more source

Astrocytes from P301S Tau mice exhibit non-canonical protein secretion and reduced morphological complexity

Neural Regeneration Research
Astrocytes have important neurosupportive functions in the brain that are altered in neurodegenerative diseases by unresolved mechanisms. We showed previously that astrocytes cultured from mice transgenic for human P301S-tau (P301S-mice) recapitulate the
Aishwarya G. Nadadhur, Matthew Mason, Johanna S. Rees, Marta Sidoryk-Wegrzynowicz, Aviva M. Tolkovsky, Maria Grazia Spillantini   +5 more
doaj   +1 more source

The Genotoxic Stress Sensor ZBP1 Drives Tau Pathology

Cells
Genotoxic stress, which includes DNA damage and the mis-localization of DNA and RNA, is a defining feature of tauopathies, Alzheimer’s disease, and several other neurodegenerative disorders.
Jessica M. Thanos, Olivia C. Campbell, Nick R. Natale, Ana Royo Marco, Michael A. Puchalski, John R. Lukens   +5 more
doaj   +1 more source

The Tauopathies [PDF]

The American Journal of Pathology, 1999
Michel Goedert, Masato Hasegawa
openaire   +1 more source

Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy [PDF]

Neurofibrillary tangles composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases collectively termed tauopathy.
Matsumoto, Kazuki, Suhara, Tetsuya, Mori, Nozomu, Kimura, Taeko, Sahara, Naruhiko, Matsumoto, Gen, Higuchi, Makoto   +6 more
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