Results 91 to 100 of about 22,537 (257)

Heterogenous Neuropathology in a Pedigree with RAB39B‐Related Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background In 2015, we reported a family with Parkinson's disease resulting from the RAB39B p.G192R (c.574G>A) variant. Since then, two affected brothers from the family have undergone autopsy. Objectives To characterize neuropathological findings, assess intracellular distribution of RAB39B protein, and examine the effect of p.G192R on α ...
Caitlin Latimer, Oswaldo Lorenzo‐Betancor, Dong‐Hui Chen, Kimmy Su, Marika Bogdani, Anna J. Park, Minsuh Kim, Joshua Weiss, Malia Callier, Ella H. Chiu, Sarah Fish, Jennifer L. Witt, Wendy H. Raskind, Marie Y. Davis, C. Dirk Keene, Cyrus P. Zabetian   +15 more
wiley   +1 more source

Globular Glial Tauopathy Type I Presenting as Atypical Progressive Aphasia, With Comorbid Limbic-Predominant Age-Related TDP-43 Encephalopathy

Frontiers in Aging Neuroscience, 2019
Globular glial tauopathies (GGTs) have heterogeneous presentations with little available information regarding typical clinical manifestations. We report on a case of atypical primary progressive aphasia (PPA) due to comorbid GGT and limbic transactive ...
Robert Rusina, Robert Rusina, Zsolt Csefalvay, Gabor G. Kovacs, Gabor G. Kovacs, Gabor G. Kovacs, Jiri Keller, Jiri Keller, Alena Javurkova, Alena Javurkova, Radoslav Matej, Radoslav Matej   +11 more
doaj   +1 more source

Role of FK506 binding protein 51 in central nervous system diseases

Frontiers in Molecular Neuroscience
FK506-binding protein 51 (FKBP51) is a pivotal molecular chaperone and scaffolding protein that integrates and modulates multiple signaling pathways—including those involving HSP90, the glucocorticoid receptor, AKT, and NF-κB—through its FK1, FK2, and ...
Haokun Peng, Yanhao Wei, Yanmei Qiu, Rentang Bi, Longhai Zeng, Bo Hu, Yanan Li   +6 more
doaj   +1 more source

Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death

Frontiers in Molecular Neuroscience, 2017
Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by cognitive impairment and memory loss. Amyloid β1-42 (Aβ) and hyper-phosphorylation of microtubule-associated protein tau have been considered as major histological features in AD.
Ki Hoon Lee, Sei-Jung Lee, Hyun Jik Lee, Gee Euhn Choi, Young Hyun Jung, Dah Ihm Kim, Amr Ahmed Gabr, Amr Ahmed Gabr, Jung Min Ryu, Ho Jae Han   +9 more
doaj   +1 more source

Caenorhabditis elegans models of tauopathy

, 2017
One of the hallmarks of the tauopathies, which include the neurodegenerative disorders, such as Alzheimer disease (AD), corticobasal degeneration, frontotemporal dementia, and progressive supranuclear palsy (PSP), is the abnormal accumulation of post ...
Ghulam Jeelani Pir, Choudhary, B., Eckhard Mandelkow, Bikash Choudhary, Mandelkow, E., Pir, G.   +5 more
core   +1 more source

Tauopathies as clinicopathological entities [PDF]

Parkinsonism & Related Disorders, 2016
Tauopathies are a class of neurodegenerative disorders characterized by neuronal and/or glial inclusions composed of the microtubule-binding protein, tau. Several lines of evidence suggest tau aggregation is central to the neurodegenerative process in tauopathies.
openaire   +2 more sources

Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity

eLife
Tauopathies represent a major class of neurodegenerative disorders associated with intracellular aggregates of the microtubule-associated protein Tau.
Anjali Bisht, Srikanth Pippadpally, Snehasis Majumder, Athulya T Gopi, Abhijit Das, Chandan Sahi, Mani Ramaswami, Vimlesh Kumar   +7 more
doaj   +1 more source

Plasticity in visual cortex is disrupted in a mouse model of tauopathy [PDF]

, 2022
Alzheimer’s disease and other dementias are thought to underlie a progressive impairment of neural plasticity. Previous work in mouse models of Alzheimer’s disease shows pronounced changes in artificially-induced plasticity in hippocampus, perirhinal and
Phillips, KG, Saleem, AB, Rodrigues, FR, Papanikolaou, A, Solomon, SG, Holeniewska, J   +5 more
core  

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

cis p-tau: early driver of brain injury and tauopathy blocked by antibody

, 2016
Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the best known environmental risk factors for chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD), whose defining pathologic features include ...
Yao, Yandan, Driver, Jane, Huang, Pengyu, Luo, Man-Li, Ryo, Akihide, Goldstein, Lee E, Lin, Yu-Min, Rotenberg, Alexander, Moncaster, Juliet, Sun, Yan, Pascual-Leone, Alvaro, Meehan, William, McKee, Ann C., Lu, Kun Ping, Qiu, Jianhua, Shahpasand, Koorosh, Wei, Shuo, Kondo, Asami, Albayram, Onder, Zhou, Xiao, Mannix, Rebekah, Chen, Chun-Hau   +21 more
core   +1 more source