Results 91 to 100 of about 19,301 (220)

Intranasal Administration of Isoeugenol Improves Memory Deficits in APP/PS1 Old Mice—A Role Beyond Nrf2 Activation?

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Inactivation of the Nrf2/Are pathway in AD leads to decreased antioxidant and anti‐inflammatory response and to the accumulation of beta‐amyloid (Aβ) plaques, resulting in cognitive failure. Treatment with Isoeugenol activates Nrf2, reversing these outcomes by promoting antioxidant response in neuronal cells (N2a) and by increasing the anti ...
Ana Silva, Sónia Silva, Jéssica Macedo, Patrícia Moreira, Diana Baptista, Joana Bicker, Ana Fortuna, Joana Liberal, Beatriz Rodrigues, Rosa Resende, Inês Vitorino, Armanda E. Santos, Bruno Miguel Neves, Cláudia Pereira, Maria Teresa Cruz   +14 more
wiley   +1 more source

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1530-1542, August 2026.
ABSTRACT Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p‐tau) and amyloid‐β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence ...
Syeda Amrah Hashmi, Aleksander Luniewski, Vanessa Smith, Matthew McCord, Jaideep Kapur, Mark Quigg, Catherine Joshua, Ifrah Zawar   +7 more
wiley   +1 more source

Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer’s-like Tauopathy Mouse Model

Cells
Basal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of Alzheimer’s disease (AD). Recent evidence suggests that tau protein is a putative target for the treatment of dementia, and the tau ...
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R. Harrington, Claude M. Wischik, Gernot Riedel, Grazyna Niewiadomska   +7 more
doaj   +1 more source

Developing a Functional Polyelectrolyte Hybrid Layer Scaffold Coating and Evaluation of Its Performance for Interaction With Neural Cells

Advanced Materials Interfaces, Volume 13, Issue 15, 4 August 2026.
Polyelectrolyte scaffold coatings modified with Cu and Fe3O4 nanoparticles regulate neural stem cell behavior in vitro. Increased Fe3O4 content enhances mitochondrial activity and neuronal differentiation, whereas higher Cu levels reduce cell viability.
Anna Grzeczkowicz, Agata Lipko, Angelika Kwiatkowska, Marcin Strawski, Monika Drabik, Ludomira H. Granicka   +5 more
wiley   +1 more source

Dorsal raphe tau pathology disrupts sleep‐wake orchestration and sleep architecture in a sex‐specific manner

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Sleep disturbances are frequent symptoms of Alzheimer's disease (AD), mirrored by early pathology in the dorsal raphe nucleus (DRN). Whether early DRN pathology can drive sleep disturbances, and the relative contributions of serotonin (5‐HT) and sex, has not been directly tested.
Louis J. Kolling, Ruixiang Wang, Gabriel S. Gaudencio, Jamie S. Fishbeyn, Thomas D. James, Suzanne M. Mason, Riley O. McCoy, Zhimin Song, Ian Pascal McConnell, Kylie Ziemke, Kasia M. Janik, Yu Xu, Gabrielle Bierlein‐De La Rosa, Shafa Ismail, Catherine Anne Marcinkiewcz   +14 more
wiley   +1 more source

Sex specificity of resistance to caTAUstrophe

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION As amyloid beta (Aβ) accumulates, tau pathology spreads beyond medial temporal lobe (MTL) into neocortical (NEO) regions, though some older adults resist this progression, or what we call here “caTAUstrophe.” Given previous evidence of higher tau levels in women, we tested how tau resistance presented in men and women separately ...
Maria Carrigan, Colin Birkenbihl, Hannah M. Klinger, Oliver Langford, Gillian T. Coughlan, Mabel Seto, Jane A. Brown, Annie Li, Madison Cuppels, Michael Properzi, Jasmeer Chhatwal, Julie Price, Aaron Schultz, Dorene Rentz, Rebecca Amariglio, Harm J. Krugers, Rik Ossenkoppele, Keith Johnson, Reisa Sperling, Timothy J. Hohman, Michael Donohue, Rachel F. Buckley   +21 more
wiley   +1 more source

The Tauopathies [PDF]

The American Journal of Pathology, 1999
Michel Goedert, Masato Hasegawa
openaire   +1 more source

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION An extra copy of the amyloid precursor protein (APP) gene causes autosomal dominant Alzheimer's disease (AD) and AD in Down syndrome (DS), but the factors underlying variability in age at onset (AAO) remain unclear. We investigated whether sporadic AD risk variants modify AAO. METHODS We analyzed clinical and genetic data from 100
Joan Groeneveld, Danna Perlaza, Clàudia Olivé, Lou Grangeon, Niccolo Tesi, Aude Nicolas, Chenyang Jiang, Itziar de Rojas, David Wallon, Stéphane Rousseau, Marta Rovira, Diego Real de Asúa, Fernando Moldenhauer, Ruihao Mu, Kévin Cassinari, Aline Zarea, Joaquim Aumatell Escabias, Jean‐Charles Lambert, Yolande A. L. Pijnenburg, Marc Hulsman, Everard G. B. Vijverberg, Johannes Levin, Mathias Jucker, Eric McDade, Juan Fortea, Henne Holstege, Flora H. Duits, Lisa Vermunt, Maulikkumar Patel, Matthew Johnson, Alan E. Renton, Alison M. Goate, Carlos Cruchaga, Cyril Pottier, Maria Victoria Fernandez, Olivia Belbin, Gael Nicolas, Oriol Dols‐Icardo, Sven J. van der Lee, Dominantly Inherited Alzheimer Network   +39 more
wiley   +1 more source

Implications of mitochondrial phosphatidylethanolamine in neuronal health and neurodegeneration

Neural Regeneration Research
Phosphatidylethanolamine is a major phospholipid class abundant in the brain, particularly in the inner leaflet of the plasma and mitochondrial membranes. Although it is primarily synthesized from phosphatidylserine via decarboxylation in mitochondria or
Yantao Zuo, Niharika Amireddy, Qian Cai
doaj   +1 more source

Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) features amyloid beta (Aβ) plaques and tau tangles, yet how their coexistence reshapes brain transcriptomic programs remains unclear. METHODS We performed high‐quality, sex‐balanced single‐nucleus RNA sequencing of 5XFAD (Aβ), PS19 (tau), and combined 5XFAD;PS19 mice.
Jung Hyun Park, Byungwook Kim, Md Mamun Al‐Amin, Mason Douglas Tate, Ahmad Daniel Sharify, Sutha K. John, Hande Karahan, Hui‐Chen Lu, Luke Child Dabin, Jungsu Kim   +9 more
wiley   +1 more source