Results 121 to 130 of about 31,957 (244)
Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.ABSTRACT SARS‐CoV‐2 infection is linked to persistent neurological symptoms Post‐Acute Sequelae SARS‐CoV‐2 (neuro‐PASC) and elevated risk of neurodegenerative disease, but molecular events connecting acute viral injury to long‐term CNS dysfunction remain unclear.
Gunjan Bawne +4 more
wiley +1 more source
Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]
, 2019 BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G +14 more
core
Galectin-3 aggravates microglial activation and tau transmission in tauopathy
The Journal of Clinical InvestigationAlzheimer’s disease is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (pTau), and microglia activation.
Jian Jing Siew +21 more
doaj +1 more source
Phytotherapy Research, Volume 40, Issue 5, Page 2604-2631, May 2026.Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli +4 more
wiley +1 more source
Brain Pathology, Volume 36, Issue 3, May 2026.We investigated neuropathological manifestations of hypothermia in 168 cases. Patients aged 65 years or more constituted 80% of the total cohort. Alzheimer's disease was the most common comorbidity, affecting 40% of all patients. Abstract There is a paucity of autopsy‐based studies providing detailed neuropathological characteristics of fatal ...
Shojiro Ichimata +2 more
wiley +1 more source
Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases [PDF]
, 2008 We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions and ...
Gil-Mi Ryu +4 more
core +1 more source
Discovery and characterization of stereodefined PMO-gapmers targeting tau
Molecular Therapy: Nucleic AcidsAntisense oligonucleotides (ASOs) are an important class of therapeutics to treat genetic diseases, and expansion of this modality to neurodegenerative disorders has been an active area of research.
Kunihiko Kanatsu +25 more
doaj +1 more source
Brain Pathology, Volume 36, Issue 3, May 2026.The study analyzed the seeding activity of misfolded tau protein in Alzheimer's disease and rapidly progressive Alzheimer's disease patients and provides evidence for the existence of different tau assemblies supported by differences in cellular toxicity and morphology of thioflavin T‐positive real‐time quaking‐induced conversion products.
Matthias Schmitz +13 more
wiley +1 more source
Advanced ScienceProtein aggregates are a hallmark of neurodegenerative disease, yet the molecular processes that control their appearance remain incompletely characterized.
Shih‐Huan Huang +8 more
doaj +1 more source
Brain Pathology, Volume 36, Issue 3, May 2026.The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown +7 more
wiley +1 more source