Results 121 to 130 of about 22,537 (257)
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Chronic traumatic encephalopathy (CTE) is a tauopathy linked to repetitive head impacts. Factors influencing brain regional susceptibility to tau deposition and spreading remain unclear. METHODS We used three datasets: [18F]flortaucipir positron emission tomography (PET) in 157 former professional American football players and 53 ...
Tim L. T. Wiegand +25 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract Patients with atypical variants of Alzheimer's disease (AD) often present at a younger age with predominantly non‐amnestic impairments and a more aggressive disease course. Historically, individuals with atypical presentations have not been included in large‐scale clinical trials, which typically focus on late‐onset, sporadic amnestic ...
Nick Corriveau‐Lecavalier +36 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION The extent to which non‐pathological aging influences plasma biomarkers remains unclear. Here, we investigate factors influencing plasma p‐tau217 levels in cognitively unimpaired (CU), amyloid‐beta–negative (Aβ‐) individuals. METHODS Plasma p‐tau217 was measured in CU Aβ‐ positron emission tomography–negative (PET‐) participants ...
Anna E Mammel +11 more
wiley +1 more source
CellsBasal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of Alzheimer’s disease (AD). Recent evidence suggests that tau protein is a putative target for the treatment of dementia, and the tau ...
Maciej Zadrozny +7 more
doaj +1 more source
Tauopathy in the PAG of old Tau.P301L mice.
, 2013 Immunohistochemistry with AT100 as tauopathy marker on midbrain coronal sections of old Tau.P301L mice reveals dramatic tauopathy in the whole PAG, affecting both its caudal (A) and rostral (B) parts.
Fred Van Leuven (259572) +7 more
core +1 more source
Allele specific expression in Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION Allele‐specific expression (ASE), preferential expression of one allele at a heterozygous locus, is implicated in various brain diseases but remains largely uncharacterized in Alzheimer's disease (AD). METHODS We performed a genome‐wide characterization of ASE variants across seven brain regions of 2,231 AD and Control patients ...
Zishan Wang +6 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION It is desirable to measure brain metabolism without needing ionizing radiation and elucidate its time trajectory. This study employed a positron emission tomography ‐validated, non‐invasive magnetic resonance imaging (MRI) technique to characterize longitudinal changes in cerebral metabolic rate of oxygen (CMRO2) in both ...
Jiani Wu +14 more
wiley +1 more source
Untangling the Tauopathy for Alzheimer’s disease and parkinsonism
, 2018 Tau is a microtubule-associated protein that mainly localizes to the axon to stabilize axonal microtubule structure and neuronal connectivity. Tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative ...
Tzu-Kang Sang +2 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION The relationship between sleep, other dementia risk factors, and dementia remains unclear. We aim to explore these associations using a two‐sample Mendelian randomization (MR) approach. METHODS We identified genetic instrumental variables for sleep characteristics from the UK Biobank and obtained summary‐level genetic association ...
Yunyun Guo +4 more
wiley +1 more source