Results 131 to 140 of about 22,537 (257)

Clinicopathological Correlates in Tauopathy and Aging

, 2022
Cognitive decline can result from both neurodegenerative or normal aging processes. Definitive diagnosis of many neurodegenerative diseases, such as Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP), requires post-mortem neuropathological
Maxwell, Selena Peggy-Lynn
core  

Mitochondrial NADK2‐dependent NADPH controls tau oligomer uptake in human neurons

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Reduced brain energy metabolism, mitochondria dysfunction, and extracellular tau oligomer buildup characterize Alzheimer's disease (AD), but how these phenomena cooperatively promote neurodegeneration is poorly understood. We now report that tau oligomers (TauOs) pathologically coordinate mitochondrial metabolism with increased ...
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena   +10 more
wiley   +1 more source

Abnormal Lipid Metabolism in Tauopathy Brains: Dysregulation and Intervention

Dysregulation of lipid metabolism is implicated in neurodegenerative diseases like Alzheimer's disease (AD). Lipid droplets (LDs) are dynamic organelles essential for cellular lipid metabolism and homeostasis.
Nie, Yuhang
core  

Choroid plexus remodeling linked to impaired CSF‐mediated clearance and Alzheimer's disease progression

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Impaired cerebrospinal fluid (CSF) ‐mediated clearance has been implicated in Alzheimer's disease (AD), but how choroid plexus (ChP) remodeling relates to these processes in vivo remains incompletely understood. METHODS In a large ADNI cohort, we integrated structural magnetic resonance imaging (MRI), amyloid/tau positron emission
Haolin Yin, Yuepeng Deng, ZiHao Lu, Yu Jiang, Chao Zuo, Jianyu Li, Linlin Guo, Binwu Ying, Giuseppe Battaglia, Xiaohe Tian, Qiyong Gong, for the Alzheimer's Disease Neuroimaging Initiative (ADNI)   +11 more
wiley   +1 more source

Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.

, 2008
The hypothesis that amyloid pathology precedes and induces the tau pathology of Alzheimer's disease is experimentally supported here through the identification of GSK-3 isozymes as a major link in the signaling pathway from amyloid to tau pathology. This
Borghgraef, Peter, Terwel, Dick, Croes, Sophie, Devijver, Herman, Muyllaert, David, Dewachter, Ilse, Van Leuven, Fred   +6 more
core   +1 more source

Blood‐based proteomic signature of amyloidosis: identification of novel regulators of amyloid load

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Cerebral amyloidosis is a defining feature of Alzheimer's disease (AD), yet the molecular heterogeneity among amyloidbeta‐positive (Aβ+) individuals remains poorly defined. We aimed to map the proteomic correlates of cerebral amyloidosis and link them to clinical variability within Aβ+ individuals.
Yike Chen, Michael R. Duggan, Jigyasha Timsina, Ying Xu, Daniel Western, Katherine Gong, Menghan Liu, John Budde, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Tammie L. S. Benzinger, Brian A. Gordon, Mahdi Moqri, Knight Alzheimer Disease Research Center (Knight‐ADRC), Laura Ibanez, Keenan A. Walker, Carlos Cruchaga, Muhammad Ali   +18 more
wiley   +1 more source

Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media

Annals of Neurology, Volume 99, Issue 6, Page 1452-1465, June 2026.
Objective Aqueously diffusible oligomers of the amyloid β‐protein (oAβ) are neurotoxic and play a role in neuronal dysfunction in Alzheimer's disease (AD). Accurate quantification of oAβ in brains and biofluids could be valuable for understanding and monitoring AD.
Yi Ran Xu, Youqi Tao, Alexandra M. Lish, Shaomin Li, Beth L. Ostaszewski, Amirah K. Anderson, Tracy Young‐Pearse, Trebor L. Lawton, Hyun‐Sik Yang, Dominic M. Walsh, Ting Yang, Dennis J. Selkoe   +11 more
wiley   +1 more source

Mitigating disparities in diagnosis of dementia

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 2, June 2026.
Abstract The field of Alzheimer's disease and related dementias (AD/ADRD) is undergoing a transformative shift with a better understanding of disease biology, biomarker‐based diagnostics, and disease‐modifying therapies. Yet, these advancements risk exacerbating existing disparities in diagnosis and care.
Lycia Tramujas Vasconcellos Neumann, Simin Mahinrad, Erin Abner, Soo Borson, Goldie S. Byrd, Maria C. Carrillo, Lindsay Clark, Anthony N. Correro II, Kacie D. Deters, Peggye Dilworth‐Anderson, Rebecca M. Edelmayer, Jason D. Flatt, Crystal M. Glover, Joshua D. Grill, Carl V. Hill, Thomas K. Karikari, Fred B. Ketchum, Emily A. Largent, Jennifer H. Lingler, Jose A. Luchsinger, Gladys E. Maestre, Michelle M. Mielke, Sid O'Bryant, Ozioma C. Okonkwo, Monica W. Parker, Annalise M. Rahman‐Filipiak, Rema Raman, Suzanne E. Schindler, Jose Soria Lopez, Shana D. Stites, Astrid M. Suchy‐Dicey, Whitney Wharton, Rachel A. Whitmer, Lisa Ann Kirk Wiese, Charles C. Windon, Amy Kind, Lisa L. Barnes   +36 more
wiley   +1 more source

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

Drug Design, Development and Therapy, 2016
Kuo-Hsuan Chang,1,* I-Cheng Chen,1,* Hsuan-Yuan Lin,2 Hsuan-Chiang Chen,2 Chih-Hsin Lin,1 Te-Hsien Lin,2 Yu-Ting Weng,1 Chih-Ying Chao,1 Yih-Ru Wu,1 Jung-Yaw Lin,2 Guey-Jen Lee-Chen,2 Chiung-Mei Chen1 1Department of Neurology, Chang Gung Memorial ...
Chang KH, Chen IC, Lin HY, Chen HC, Lin CH, Lin TH, Weng YT, Chao CY, Wu YR, Lin JY, Lee-Chen GJ, Chen CM   +11 more
doaj  

Loss of Smek1 Induces Tauopathy and Triggers Neurodegeneration by Regulating Microtubule Stability

Advanced Science
Suppressor of Mek1 (Smek1) is a regulatory subunit of protein phosphatase 4. Genome‐wide association studies have shown the protective effect of SMEK1 in Alzheimer's disease (AD). However, the physiological and pathological roles of Smek1 in AD and other
Ruo‐Nan Duan, Ai Liu, Yue‐Qing Sun, Yun‐Fang Xie, Shi‐Jun Wei, Shang Gao, Yi‐Ming Liu, Xi Li, Wen‐Jie Sun, Jiang‐Xia Li, Chuan‐Zhu Yan, Qi‐Ji Liu   +11 more
doaj   +1 more source