Results 151 to 160 of about 22,537 (257)

Rhizomes as Multi-Target Pharmacological Platforms Against Tauopathy: Neuro-Metabolic Crosstalk, Drug-Likeness, and Translational Challenges. [PDF]

Pharmaceuticals (Basel)
Setiawan AW, Choi J, Park S, Choi M, Tjandrawinata RR, Hadinata E, Park MN, Ikrar T, Nurkolis F, Kim B.   +9 more
europepmc   +1 more source

Deciphering Freezing of Gait: What Neuropathology Reveals About an Episodic Phenomenon

European Journal of Neuroscience, Volume 63, Issue 12, June 2026.
Freezing of gait (FoG) occurs across Parkinson's disease, multiple neurodegenerative conditions and non‐neurodegenerative disorders. This review synthesizes the structural, neurochemical and proteinopathic substrates underlying FoG, showing how cumulative damage to distributed locomotor circuits—compounded by overlapping pathologies—progressively ...
Gabor G. Kovacs
wiley   +1 more source

Modification of early behavioural, physiological and neuropathological endpoints by syntaxin-6 knockout in a humanised P301S transgenic model of tauopathy. [PDF]

Acta Neuropathol
Hill E, Linehan J, Farmer M, Jakubcova T, Hamdan S, Tomlinson A, Purro S, Argentina F, Jones E, Kaye N, Fitzhugh C, de Silva R, Brandner S, Collinge J, Cunningham TJ, Mead S.   +15 more
europepmc   +1 more source

Clinicopathological features of primary tauopathies: a brain bank series. [PDF]

Front Neurol
Ryan B, Marriott L, Murray H, Faull RLM, Turner CP, Curtis MA.   +5 more
europepmc   +1 more source

An Integrative Proteomic Approach to Reveal Altered Signaling Modules During Alzheimer's Disease Progression in PS19 Tauopathy Mice. [PDF]

Mol Cell Proteomics
Cho E, Lee S, Lee H, Kim J, Kwon YW, Hoe HS, Kim D, Yoon JH.   +7 more
europepmc   +1 more source

Comparison of Proteomic Analysis of Cerebrospinal Fluid From Neurological Patients With and Without Amyotrophic Lateral Sclerosis

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness in both bulbar and extremity muscles, leading to a diverse clinical phenotype with motor and non‐motor symptoms. Cerebrospinal fluid (CSF) from sporadic ALS patients were analysed for proteomics content and revealed altered inflammatory and ...
Eleonora Sabetta, Karin Rallmann, Pille Taba, Abigail L. Pfaff, Bal Hari Poudel, Davide Ferrari, Massimo Locatelli, Sulev Kõks, Jonas Bergquist   +8 more
wiley   +1 more source

Inhibition of beta-arrestin oligomerization in tauopathy

As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when
Woo, Jung A., Lewandowski, Eric, Liggett, Stephen Bryant, Kang, David E., Chen, Yu   +4 more
core  

Mass spectrometry-based proteomic profiling of human tauopathy brains suggests mitochondria-associated alterations. [PDF]

Front Mol Neurosci
Jannah AR, Hasegawa M, Ham J, Hara N, Tsukie T, Obinata A, Kikuchi M, Kasuga K, Yamaguchi H, Hamasaki H, Tada M, Kakita A, Matsumoto M, Miyashita A, Ikeuchi T.   +14 more
europepmc   +1 more source

AAIC 2026 to kick off July 12 in London, United Kingdom, and online

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
wiley   +1 more source

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source