Results 1 to 10 of about 18,473 (221)
Oxidative Stress in Tauopathies: From Cause to Therapy [PDF]
Antioxidants, 2022 Oxidative stress (OS) is the result of an imbalance between the production of reactive oxygen species (ROS) and the antioxidant capacity of cells. Due to its high oxygen demand, the human brain is highly susceptible to OS and, thus, it is not a surprise ...
Fernando Bartolomé-Robledo +2 more
exaly +4 more sources
Astrocytes in Tauopathies [PDF]
Frontiers in Neurology, 2020 Tauopathies are a group of neurodegenerative diseases characterized by the progressive accumulation across the brain of hyperphosphorylated aggregates of the microtubule-associated protein tau that vary in isoform composition, structural conformation and
Matthew J. Reid +4 more
doaj +6 more sources
Cells, 2021 Genetic and sporadic forms of tauopathies, the most prevalent of which is Alzheimer’s Disease, are a scourge of the aging society, and in the case of genetic forms, can also affect children and young adults.
Geraldine Zimmer-Bensch, Hans Zempel
doaj +2 more sources
Astrogliopathy in Tauopathies [PDF]
Neuroglia, 2018 Astrocytes are involved in many diseases of the central nervous system, not only as reactive cells to neuronal damage but also as primary actors in the pathological process. Astrogliopathy is a term used to designate the involvement of astrocytes as key elements in the pathogenesis and pathology of diseases and injuries of the central nervous system ...
Isidro Ferrer
core +5 more sources
Cellular and pathological heterogeneity of primary tauopathies
Molecular Neurodegeneration, 2021 Microtubule-associated protein tau is abnormally aggregated in neuronal and glial cells in a range of neurodegenerative diseases that are collectively referred to as tauopathies.
Dah-eun Chloe Chung +3 more
doaj +2 more sources
Annual Review of Neuroscience, 2001 ▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent filamentous tau inclusions and brain degeneration in the absence of β-amyloid deposits are also hallmarks of neurodegenerative tauopathies exemplified by sporadic corticobasal ...
V M, Lee, M, Goedert, J Q, Trojanowski
openaire +3 more sources
Clinical Spectrum of Tauopathies [PDF]
Frontiers in Neurology, 2022 Tauopathies are both clinical and pathological heterogeneous disorders characterized by neuronal and/or glial accumulation of misfolded tau protein. It is now well understood that every pathologic tauopathy may present with various clinical phenotypes based on the primary site of involvement and the spread and distribution of the pathology in the ...
Nahid Olfati +3 more
openaire +6 more sources
Nature Communications, 2023 Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The tau isoforms observed in post mortem human brain aggregates is used to classify tauopathies.
Nathalie Kyalu Ngoie Zola +11 more
doaj +2 more sources
Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms
Frontiers in Neuroscience, 2017 Tauopathies are a diverse group of diseases featuring progressive dying-back neurodegeneration of specific neuronal populations in association with accumulation of abnormal forms of the microtubule-associated protein tau.
Andrew Kneynsberg +8 more
doaj +3 more sources
Progress in Neurobiology, 2019 Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative diseases defined by cytoplasmic inclusions predominantly composed of tau protein isoforms with four microtubule-binding domains.
Roesler, Thomas W. +17 more
openaire +5 more sources