Results 41 to 50 of about 18,473 (221)

In Vivo Assessment of Neuroinflammation in 4-Repeat Tauopathies. [PDF]

, 2020
BACKGROUND Neuroinflammation has received growing interest as a therapeutic target in neurodegenerative disorders, including 4-repeat tauopathies. OBJECTIVES The aim of this cross-sectional study was to investigate 18 kDa translocator protein ...
Leonie Beyer, Boris‐Stephan Rauchmann, Palleis, Carla, Robert Perneczky, Estrella Morenas‐Rodriguez, Alexander Nitschmann, Francois Ruch‐Rubinstein, Christian Haass, Jochen Herms, Prix, Catharina, Danek, Adrian, Stoecklein, Sophia, Adrian Danek, Gloria Biechele, Unterrainer, Marcus, Catharina Prix, Harris, Stefanie, Levin, Johannes, Eckenweber, Florian, Beyer, Leonie, Morenas-Rodriguez, Estrella, Stefanie Harris, Ruch‐Rubinstein, Francois, Julia Sauerbeck, Stöcklein, Sophia, Rainer Rupprecht, Axel Rominger, Johannes Levin, Lindner, Simon, Simon Lindner, Höglinger, Günter U., Endy Weidinger, Marcus Unterrainer, Nathalie L. Albert, Morenas‐Rodriguez, Estrella, Bötzel, Kai, Blume, Tanja, Wetzel, Christian, Florian Eckenweber, Christian Wetzel, Tanja Blume, Herms, Jochen, Weidinger, Endy, Kai Bötzel, Sophia Stöcklein, Nitschmann, Alexander, Albert, Nathalie L, Rauchmann, Boris‐Stephan, Finze, Anika, Biechele, Gloria, Rominger, Axel, Haass, Christian, Ruch-Rubinstein, Francois, Brendel, Matthias, Shi, Yuan, Sauerbeck, Julia, Perneczky, Robert, Rupprecht, Rainer, Julia Schmitt, Matthias Brendel, Schmitt, Julia, Rauchmann, Boris-Stephan, Peter Bartenstein, Yuan Shi, Carla Palleis, Höglinger, Günter U, Anika Finze, Albert, Nathalie L., Bartenstein, Peter, Günter U. Höglinger   +69 more
core   +2 more sources

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration

Frontiers in Neuroscience, 2021
The human tau protein is implicated in a wide range of neurodegenerative “tauopathy” diseases, consisting of Alzheimer’s disease (AD) and frontotemporal lobar degeneration which includes progressive supranuclear palsy, corticobasal degeneration, Pick’s ...
Ben Boyarko, Vivian Hook, Vivian Hook
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Modifications of Lysine Residues 294 and 311 Within the Microtubule‐Binding Region Alter Tau Aggregation and Tubulin Binding Equilibria

Angewandte Chemie, EarlyView.
The molecular consequences of specific lysine modifications in Alzheimer´s disease remain insufficiently resolved in the context of full‐length protein. Here we integrate protein semisynthesis, segmental isotope labelling, and high‐resolution NMR spectroscopy to achieve residue‐resolved interrogation of site‐specific acetylation and carboxymethylation.
Dominik P. Vogl, Mario Migotti, Robert Konrat, Anne C. Conibear, Christian F. W. Becker   +4 more
wiley   +2 more sources

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Environmental tauopathies [PDF]

, 2016
Neurodegenerative diseases, of which tauopathies form a major class, are increasing in prevalence worldwide. Tauopathies are characterized by the presence of abnormal neuronal and glial inclusions that are composed predominantly of the microtubule ...
Green, Cari Lynn
core   +1 more source

Stratification of brain-derived extracellular vesicles of Alzheimer’s disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles

Translational Neurodegeneration
Background Alzheimer’s disease (AD) is the most prominent form of dementia worldwide. It is characterized by tau lesions that spread throughout the brain in a spatio-temporal manner.
Marie Oosterlynck, Elodie Leroux, Balasubramaniam Namasivayam, Thomas Bouillet, Raphaelle Caillierez, Anne Loyens, Daniele Mazur, Romain Perbet, Christophe Lefebvre, Soulaimane Aboulouard, Claude-Alain Maurage, Bertrand Accart, Luc Buée, Morvane Colin   +13 more
doaj   +1 more source

The Sulfation Code of Tauopathies: Heparan Sulfate Proteoglycans in the Prion Like Spread of Tau Pathology

Frontiers in Molecular Biosciences, 2021
Tauopathies are a heterogenous family of progressive neurodegenerative diseases defined by the appearance of proteinaceous lesions within the brain composed of abnormally folded species of Microtubule Associated Protein Tau (tau). Alzheimer’s Disease (AD)
Dylan Mah, Jing Zhao, Jing Zhao, Xinyue Liu, Xinyue Liu, Fuming Zhang, Jian Liu, Lianchun Wang, Robert Linhardt, Chunyu Wang   +9 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source