Results 61 to 70 of about 18,473 (221)
Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies
Translational NeurodegenerationThe deposition of abnormal tau protein is characteristic of Alzheimer’s disease (AD) and a class of neurodegenerative diseases called tauopathies. Physiologically, tau maintains an intrinsically disordered structure and plays diverse roles in neurons ...
Xingyu Zhang +3 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer’s disease (AD) and mitigates both amyloid and Tau lesions in transgenic mouse models of the disease.
Emilie Faivre +22 more
doaj +1 more source
A Multi-Criteria Decision Aid Tool for Radiopharmaceutical Selection in Tau PET Imaging
Pharmaceutics, 2023 The accumulation of pathologically misfolded tau is a feature shared by a group of neurodegenerative disorders collectively referred to as tauopathies. Alzheimer’s disease (AD) is the most prevalent of these tauopathies.
Ilker Ozsahin +4 more
doaj +1 more source
A Tale of Two Tauopathies [PDF]
Neurology, 2011 A 77-year-old man developed progressive language and balance difficulties. He had difficulty rising from a chair, with falls occurring within the first year of symptoms. After 1 year, rapid, spontaneous jerks appeared in the left hand, which he described as “useless.” Neurologic examination 3 years after his initial symptoms demonstrated 23/30 on the ...
Jason S, Hawley +2 more
openaire +2 more sources
Advanced Science, EarlyView.Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu +16 more
wiley +1 more source
Tau exhibits unique seeding properties in globular glial tauopathy
Acta Neuropathologica Communications, 2019 Tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. They are clinically and pathologically heterogeneous depending on the isoform of tau protein that accumulates (three or ...
Dah-eun Chloe Chung +9 more
doaj +1 more source
Advanced Science, EarlyView.This study establishes a universally applicable framework for vesicle surface analysis by combining engineered amyloid‐β‐displaying nanovesicles with machine‐learning‐optimized impedance spectroscopy. Equivalent‐circuit modeling reveals that membrane capacitance correlates with the surface protein states, enabling label‐free quantification of vesicle ...
Jaeyoon Song +5 more
wiley +1 more source
BiomoleculesTauopathies are a diverse group of neurodegenerative diseases characterized by the presence of Tau inclusions in neurons and glia. Rather than the classic steps in the transformation of Tau into neurofibrillary tangles, as first studied in Alzheimer’s ...
Danton H. O’Day
doaj +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source