Results 61 to 70 of about 1,190 (173)
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Cognitive health in postmenopausal women is significantly affected by hormonal shifts, especially the drop in estrogen levels. This review explores the intricate relationship between menopause and cognitive functions across six domains: perception, attention, memory, language, executive functioning, and motor skills.
Suvarna Khadilkar +3 more
wiley +1 more source
Sex differences for clinical presentations and co-pathologies in four-repeat tauopathies
Biology of Sex DifferencesBackground Four-repeat (4R)-tauopathies cause variable clinical profiles leading to clinical misdiagnosis. While sex differences are reported in Alzheimer’s disease (AD), Lewy body disease (LBD), and clinically-defined frontotemporal dementia (FTD ...
Ece Bayram +4 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.Background Progressive supranuclear palsy (PSP) is a rare and devastating tauopathy with limited global data. Given India's large population, genetic diversity, and clinical heterogeneity, large multicenter datasets are crucial to enrich global understanding of PSP. Objective To characterize the demographic, clinical, and phenotypic profiles of a large
Prashanth Lingappa Kukkle +31 more
wiley +1 more source
Tau-Cofactor Complexes as Building Blocks of Tau Fibrils
Frontiers in Neuroscience, 2019 The aggregation of the human tau protein into neurofibrillary tangles is directly diagnostic of many neurodegenerative conditions termed tauopathies.
Yann Fichou +7 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider +3 more
wiley +1 more source
Experimental modeling for tauopathies: An isogenic panel of humanized MAPT knock-in mice
Neuroscience ResearchTauopathies are a group of neurodegenerative diseases characterized by the aberrant accumulation of tau protein in the brain. While numerous mouse models have been developed to study tauopathies, the majority depend on tau overexpression, which may ...
Takahiro Morito, Naoto Watamura
doaj +1 more source
What is the evidence that tau pathology spreads through prion-like propagation?
Acta Neuropathologica Communications, 2017 Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas.
Amrit Mudher +10 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background Emerging evidence implicates neuroinflammation in progressive supranuclear palsy (PSP) pathophysiology, with elevated cyto‐chemokines suggesting natural killer (NK) cell involvement. Methods We characterized peripheral NK in PSP (N = 11) versus Parkinson's disease (PD, N = 10) and healthy controls (HC, N = 8) at both ...
Marina Picillo +11 more
wiley +1 more source
New Features about Tau Function and Dysfunction
Biomolecules, 2016 Tau is a brain microtubule-associated protein that directly binds to a microtubule and dynamically regulates its structure and function. Under pathological conditions, tau self-assembles into filamentous structures that end up forming neurofibrillary ...
Miguel Medina +2 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background Differentiating progressive supranuclear palsy (PSP) from Parkinson's disease (PD) can be clinically challenging. In the neuroimaging field, radiomics has emerged as a promising approach to capture subtle microstructural and textural image alterations, improving differential diagnoses.
Chiara Camastra +8 more
wiley +1 more source