Results 71 to 80 of about 13,185 (147)

Oxidative stress-induced stress granules: a central link to protein aggregation in neurodegenerative diseases

Frontiers in Neuroscience
Intracellular aggregation of proteins such as Tau, TDP43, FUS, prion protein, and α-synuclein is a major hallmark of many major neurodegenerative diseases. Aberrant stress granules (SGs) are emerging as key contributors to the nucleation of toxic protein
Neelam Younas, Neelam Younas, Inga Zerr, Inga Zerr   +3 more
doaj   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Lineage-specific splicing regulation of MAPT gene in the primate brain

Cell Genomics
Summary: Divergence of precursor messenger RNA (pre-mRNA) alternative splicing (AS) is widespread in mammals, including primates, but the underlying mechanisms and functional impact are poorly understood.
Yocelyn Recinos, Suying Bao, Xiaojian Wang, Brittany L. Phillips, Yow-Tyng Yeh, Sebastien M. Weyn-Vanhentenryck, Maurice S. Swanson, Chaolin Zhang   +7 more
doaj   +1 more source

Elevated Plasma Phospho‐Tau217 in Beta‐Propeller Protein‐Associated Neurodegeneration

Movement Disorders, EarlyView.
Jae‐Hyeok Lee, Yun Soo Kim
wiley   +1 more source

The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs
Nazlı Şevval Menemenli, Bünyamin Akgül   +1 more
wiley   +1 more source

Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders

Frontiers in Aging Neuroscience
Tauopathies are neurodegenerative disorders characterized by the abnormal accumulation and aggregation of hyperphosphorylated tau protein. They can be primary or secondary depending on whether tau inclusions are the predominant pathology (e.g ...
Julia C. Colwell, Julia C. Colwell, Marina E. Emborg, Marina E. Emborg, Marina E. Emborg   +4 more
doaj   +1 more source

Visible Tongue Fasciculations With Electromyographic Denervation in Autopsy‐Proven Progressive Supranuclear Palsy Mimicking Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
Hiroyasu Inoue, Yoshihiko Horimoto, Yo Tsuda, Yuta Madokoro, Shoji Kawashima, Akio Akagi, Yasushi Iwasaki, Noriyuki Matsukawa   +7 more
wiley   +1 more source

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle, Fabio Lolicato, Carmelo Tempra, Martina Pannuzzo, Michele F. M. Sciacca, Danilo Milardi, Carmelo La Rosa   +6 more
wiley   +1 more source

A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo

Frontiers in Cellular Neuroscience
The failure of the autophagy-lysosomal pathway to clear the pathogenic forms of Tau exacerbates the pathogenesis of tauopathies. We have previously shown that the immunophilin FKBP52 interacts both physically and functionally with Tau, and that a ...
Emilie Lesport, Emilie Lesport, Lucie Commeau, Mélanie Genet, Etienne-Emile Baulieu, Etienne-Emile Baulieu, Marcel Tawk, Julien Giustiniani, Julien Giustiniani   +8 more
doaj   +1 more source

Homogenization of Smoluchowski-type equations with transmission boundary conditions

Advanced Nonlinear Studies
In this work, we prove a two-scale homogenization result for a set of diffusion-coagulation Smoluchowski-type equations with transmission boundary conditions.
Franchi Bruno, Lorenzani Silvia
doaj   +1 more source