Results 91 to 100 of about 18,473 (221)
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Brain Pathology, EarlyView.This study investigates amyloid‐beta (Aβ) pathology in a forensic autopsy cohort of relatively young individuals (40–69 years). Using detailed immunohistochemical analyses of multiple Aβ species, we demonstrate marked regional and molecular heterogeneity, particularly within the striatum.
Shojiro Ichimata +4 more
wiley +1 more source
Biomolecular Concepts, 2018 The microtubule-associated protein Tau plays a crucial role in stabilizing neuronal microtubules. In Tauopathies, Tau loses its ability to bind microtubules, detach from them and forms intracellular aggregates.
Pérez Mar +3 more
doaj +1 more source
Neuropsychiatric features of parkinsonian tauopathies and alpha-synucleinopathies. [PDF]
, 2008 The goal of this thesis is to determine if neuropsychiatric features can differentiate parkinsonian patients with: tauopathies from those with alpha-synucleinopathies and explore caregiver distress.
Thompson, Megan Rayne, 1985-
core +1 more source
Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration
Brain Pathology, EarlyView.Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk +6 more
wiley +1 more source
مجله علمی دانشگاه علوم پزشکی کردستان, 2021 Background and Aim: Tau protein is a microtubule-associated protein that plays a critical role in microtubule dynamics and maintaining the structure of neurons.
Mohammad Majidi +2 more
doaj
Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations
Journal of Intellectual Disability Research, EarlyView.ABSTRACT Background Down syndrome (DS) entails widespread age‐related functional decline affecting multiple organ systems, including genetically determined early‐onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life.
Georg Nübling +11 more
wiley +1 more source
Heritability in frontotemporal tauopathies
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019 AbstractIntroductionExploring the degree of heritability in a large cohort of frontotemporal lobar degeneration with tau‐immunopositive inclusions (FTLD‐tau) and determining if different FTLD‐tau subtypes are associated with stronger heritability will provide important insight into disease pathogenesis.MethodsUsing modified Goldman pedigree ...
Shelley L. Forrest +9 more
openaire +3 more sources
Elevated Plasma Phospho‐Tau217 in Beta‐Propeller Protein‐Associated Neurodegeneration
Movement Disorders, EarlyView.
Jae‐Hyeok Lee, Yun Soo Kim
wiley +1 more source
Brain Pathology, Volume 36, Issue 6, November 2026.We generated digital pathologic algorithms (AI‐based modules that can be freely shared) to: optimize the sampling (ROI) for diagnosis of ADNC‐related tau pathology; compare/transition between Aperio and HALO platforms; and rationalize severe Braak NFT staging, so that all Braak‐VI cases had dementia, and all Braak‐V cases had MCI or dementia.
Ryan K. Shahidehpour +10 more
wiley +1 more source