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Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice [PDF]
Frontiers in Molecular Neuroscience, 2020 Alzheimer’s disease (AD) is characterized by the accumulation in the brain of intraneuronal aggregates of abnormally and hyperphosphorylated tau proteins and of extracellular deposits of amyloid-β surrounded by dystrophic neurites.
Sarah Houben +9 more
doaj +2 more sources
Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease [PDF]
Cell Reports, 2019 Summary: A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotypes ...
Eleanor K. Pickett +29 more
doaj +5 more sources
Autophagy and Tau Protein [PDF]
International Journal of Molecular Sciences, 2021 Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques (SPs) are pathological hallmarks of Alzheimer’s disease (AD). In swollen axons, many autophagic vacuoles are observed around SP in the AD brain. This suggests that autophagy function is disturbed in AD.
Tadanori Hamano +6 more
openaire +2 more sources
Tau interactome and RNA binding proteins in neurodegenerative diseases
Molecular Neurodegeneration, 2022 Pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates in these diseases the affected brain regions, clinical symptoms, and morphology ...
Tomas Kavanagh +2 more
doaj +1 more source
Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey
Biomedicines, 2022 Tau proteins are known to be mainly involved in regulation of microtubule dynamics. Besides this function, which is critical for axonal transport and signal transduction, tau proteins also have other roles in neurons.
Paulo J. da Costa +3 more
doaj +1 more source
Molecular Neurodegeneration, 2022 Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration.
Pieter Jelle Visser +29 more
doaj +1 more source
The C291R Tau variant forms different types of protofibrils [PDF]
, 2020 Mutations in the MAPT gene can lead to disease-associated variants of tau. However, the pathological mechanisms behind these genetic tauopathies are poorly understood. Here, we characterized the aggregation stages and conformational changes of tau C291R,
Karikari, Thomas K. +2 more
core +1 more source
TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation [PDF]
BioMed Research International, 2015 Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes. Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and cellular processes involved.
Liao, Jung-Chi +4 more
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Neurobiology of Disease, 2022 Neurofibrillary tangles (NFT), a neuronal lesion found in Alzheimer's disease (AD), are composed of fibrillary aggregates of modified forms of tau proteins.
M.-A. de Fisenne +7 more
doaj +1 more source
Tau: A Signaling Hub Protein [PDF]
Frontiers in Molecular Neuroscience, 2021 Over four decades ago,in vitroexperiments showed that tau protein interacts with and stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the widespread hypotheses that these properties extend to living neurons and that reduced stability of microtubules represents a major disease-driving event induced by pathological ...
Rebecca L. Mueller +11 more
openaire +4 more sources