Results 1 to 10 of about 104,701 (117)

Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice [PDF]

Frontiers in Molecular Neuroscience, 2020
Alzheimer’s disease (AD) is characterized by the accumulation in the brain of intraneuronal aggregates of abnormally and hyperphosphorylated tau proteins and of extracellular deposits of amyloid-β surrounded by dystrophic neurites.
Sarah Houben, Marie-Ange de Fisenne, Kunie Ando, Virginie Vanden Dries, Luc Poncelet, Zehra Yilmaz, Salwa Mansour, Robert De Decker, Jean-Pierre Brion, Karelle Leroy   +9 more
doaj   +2 more sources

Electrochemical Immunosensors Developed for Amyloid-Beta and Tau Proteins, Leading Biomarkers of Alzheimer’s Disease [PDF]

Biosensors, 2023
Masoud Negahdary, N Sattarahmady, Hossein Heli   +2 more
exaly   +2 more sources

Tau Proteins and Tauopathies in Alzheimer’s Disease [PDF]

Cellular and Molecular Neurobiology, 2018
Chye Soi Moi, Khuen Yen Ng, Rhun Yian Koh   +2 more
exaly   +2 more sources

Tau interactome and RNA binding proteins in neurodegenerative diseases

Molecular Neurodegeneration, 2022
Pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates in these diseases the affected brain regions, clinical symptoms, and morphology ...
Tomas Kavanagh, Aditi Halder, Eleanor Drummond   +2 more
doaj   +1 more source

Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey

Biomedicines, 2022
Tau proteins are known to be mainly involved in regulation of microtubule dynamics. Besides this function, which is critical for axonal transport and signal transduction, tau proteins also have other roles in neurons.
Paulo J. da Costa, Malika Hamdane, Luc Buée, Franck Martin   +3 more
doaj   +1 more source

Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease

Molecular Neurodegeneration, 2022
Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration.
Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J. B. Vos, Isabelle Bos, ADNI, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms   +29 more
doaj   +1 more source

Alzheimer PHF-tau aggregates do not spread tau pathology to the brain via the Retino-tectal projection after intraocular injection in male mouse models

Neurobiology of Disease, 2022
Neurofibrillary tangles (NFT), a neuronal lesion found in Alzheimer's disease (AD), are composed of fibrillary aggregates of modified forms of tau proteins.
M.-A. de Fisenne, Z. Yilmaz, R. De Decker, V. Suain, L. Buée, K. Ando, J.-P. Brion, K. Leroy   +7 more
doaj   +1 more source

Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks

Frontiers in Aging Neuroscience, 2022
Background and objectiveBlood-based biomarkers represent a promising approach to help identify early Alzheimer’s disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for potential ...
Yuting Zhang, Upamanyu Ghose, Noel J. Buckley, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Kristel Sleegers, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleó, Julius Popp, Julius Popp, Pablo Martinez-Lage, Cristina Legido-Quigley, Cristina Legido-Quigley, Frederik Barkhof, Frederik Barkhof, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Pieter Jelle Visser, Pieter Jelle Visser, Lars Bertram, Lars Bertram, Simon Lovestone, Simon Lovestone, Alejo J. Nevado-Holgado, Liu Shi   +30 more
doaj   +1 more source

RNA binding proteins co-localize with small tau inclusions in tauopathy

Acta Neuropathologica Communications, 2018
The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer’s disease (AD).
Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F. Abisambra, Hu Li, Benjamin Wolozin   +11 more
doaj   +1 more source

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis

Frontiers in Aging Neuroscience, 2017
Microtubule-associated protein tau is hyperphosphorylated and aggregated in affected neurons in Alzheimer disease (AD) brains. The tau pathology starts from the entorhinal cortex (EC), spreads to the hippocampus and frontal and temporal cortices, and ...
Wen Hu, Wen Hu, Feng Wu, Yanchong Zhang, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Liu, Fei Liu   +8 more
doaj   +1 more source