Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice [PDF]
Frontiers in Molecular Neuroscience, 2020 Alzheimer’s disease (AD) is characterized by the accumulation in the brain of intraneuronal aggregates of abnormally and hyperphosphorylated tau proteins and of extracellular deposits of amyloid-β surrounded by dystrophic neurites.
Sarah Houben +9 more
doaj +2 more sources
Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer’s Disease Progression [PDF]
International Journal of Molecular Sciences, 2020 Total tau (t-tau) and phosphorylated tau (p-tau) protein elevations in cerebrospinal fluid (CFS) are well-established hallmarks of Alzheimer’s disease (AD), while the associations of serum t-tau and p-tau levels with AD have been inconsistent ...
Eunjoo Nam, Yeong-Bae Lee, Cheil Moon
exaly +4 more sources
Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey
Biomedicines, 2022 Tau proteins are known to be mainly involved in regulation of microtubule dynamics. Besides this function, which is critical for axonal transport and signal transduction, tau proteins also have other roles in neurons.
Paulo J. da Costa +3 more
doaj +2 more sources
Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis [PDF]
Frontiers in Aging Neuroscience, 2017 Microtubule-associated protein tau is hyperphosphorylated and aggregated in affected neurons in Alzheimer disease (AD) brains. The tau pathology starts from the entorhinal cortex (EC), spreads to the hippocampus and frontal and temporal cortices, and ...
Wen Hu +8 more
doaj +2 more sources
Neurofilaments and tau proteins in cerebrospinal fluid and serum in dementias and neuroinflammation
Biomedical Papers, 2017 Aims: The aim of this study was to evaluate the diagnostic potential of cerebrospinal fluid (CSF) and serum levels of neurocytoskeletal proteins and their ratios for the diagnosis of dementias and to assess the differences in neurocytoskeletal proteins ...
Lenka Fialova +2 more
doaj +3 more sources
Electrochemical Immunosensors Developed for Amyloid-Beta and Tau Proteins, Leading Biomarkers of Alzheimer’s Disease [PDF]
Biosensors, 2023 Lucio Angnes +2 more
exaly +2 more sources
Autophagy and Tau Protein [PDF]
International Journal of Molecular Sciences, 2021 Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques (SPs) are pathological hallmarks of Alzheimer’s disease (AD). In swollen axons, many autophagic vacuoles are observed around SP in the AD brain. This suggests that autophagy function is disturbed in AD.
Tadanori Hamano +6 more
openaire +2 more sources
Tau interactome and RNA binding proteins in neurodegenerative diseases
Molecular Neurodegeneration, 2022 Pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates in these diseases the affected brain regions, clinical symptoms, and morphology ...
Tomas Kavanagh +2 more
doaj +1 more source
Tau Proteins and Tauopathies in Alzheimer’s Disease [PDF]
Cellular and Molecular Neurobiology, 2018 Khuen Yen Ng, Rhun Yian Koh
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Amyloidogenesis of Tau protein [PDF]
Protein Science, 2017 AbstractThe role of microtubule‐associated protein Tau in neurodegeneration has been extensively investigated since the discovery of Tau amyloid aggregates in the brains of patients with Alzheimer's disease (AD). The process of formation of amyloid fibrils is known as amyloidogenesis and attracts much attention as a potential target in the prevention ...
Bartosz Nizynski +2 more
openaire +3 more sources