Results 21 to 30 of about 104,850 (261)

Alzheimer disease pathology and the cerebrospinal fluid proteome

Alzheimer’s Research & Therapy, 2018
Background Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and tau-related neurodegeneration have ...
Loïc Dayon, Antonio Núñez Galindo, Jérôme Wojcik, Ornella Cominetti, John Corthésy, Aikaterini Oikonomidi, Hugues Henry, Martin Kussmann, Eugenia Migliavacca, India Severin, Gene L. Bowman, Julius Popp   +11 more
doaj   +1 more source

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

Cell Reports, 2016
Summary: Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the ...
Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin   +15 more
doaj   +1 more source

An Update on Blood-Based Markers of Alzheimer’s Disease Using the SiMoA Platform

Neurology and Therapy, 2019
The development of blood-based biomarkers of Alzheimer’s disease (AD) pathology as tools for screening the general population, and as the first step in a multistep process to determine which non-demented individuals are at greatest risk of developing AD ...
Danni Li, Michelle M. Mielke
doaj   +1 more source

Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies

Frontiers in Neuroscience, 2020
Tauopathies are the most common type of neurodegenerative proteinopathy, being characterized by cytoplasmic aggregates of hyperphosphorylated tau protein. The formation and morphologies of these tau inclusions, the distribution of the lesions and related
Fuyuki Kametani, Mari Yoshida, Tomoyasu Matsubara, Shigeo Murayama, Yuko Saito, Ito Kawakami, Mitsumoto Onaya, Hidetomo Tanaka, Akiyoshi Kakita, Andrew C. Robinson, David M. A. Mann, Masato Hasegawa   +11 more
doaj   +1 more source

Differences Between Human and Murine Tau at the N-terminal End

Frontiers in Aging Neuroscience, 2020
Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the ...
Félix Hernández, Félix Hernández, Jesús Merchán-Rubira, Laura Vallés-Saiz, Alberto Rodríguez-Matellán, Jesús Avila, Jesús Avila   +6 more
doaj   +1 more source

Tau Protein and Neurodegeneration

Alzheimer's & Dementia, 2004
Abstract Background In 1988, we showed that tau protein is an integral component of the paired helical filaments (PHFs) of Alzheimer's disease. Over thirty neurodegenerative diseases are now known to exhibit filamentous tau inclusions. We identified the six tau isoforms that are produced in the
openaire   +3 more sources

Tau Protein: Function and Pathology [PDF]

International Journal of Alzheimer's Disease, 2012
In the last decade, the fundamental role of the microtubule-associated protein tau in neurodegeneration and dementia has been widely accepted. The generation of various transgenic models for tau pathology, varying in expressed mutations and driving promoters with either permanent (constitutive) or inducible expression, as well as the use of alternative
Rosenmann, Hanna, Blum, David, Kayed, Rakez, Ittner, Lars M.   +3 more
openaire   +2 more sources

Improved Expression of Aggregation-Prone Tau Proteins Using a Spidroin-Derived Solubility Tag

Separations
Tauopathies, a group of neurodegenerative disorders, are characterized by the abnormal aggregation of microtubule-associated Tau proteins in neurons and glial cells.
Kevin Muwonge, Bedri Yaman, Attila Mészáros, Giorgio Russo, Alexander Volkov, Peter Tompa   +5 more
doaj   +1 more source

DnaJC7 specifically regulates tau seeding

eLife, 2023
Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate.
Valerie Ann Perez, David W Sanders, Ayde Mendoza-Oliva, Barbara Elena Stopschinski, Vishruth Mullapudi, Charles L White, Lukasz A Joachimiak, Marc I Diamond   +7 more
doaj   +1 more source

SUMO1 modification of 0N4R-tau is regulated by PIASx, SENP1, SENP2, and TRIM11

Biochemistry and Biophysics Reports
Tau is a microtubule-associated protein that contributes to cytoskeletal stabilization. Aggregation of tau proteins is associated with neurodegenerative disorders such as Alzheimer's disease.
Harmony Wada, Takuma Maruyama, Takako Niikura   +2 more
doaj   +1 more source