Results 21 to 30 of about 110,474 (301)

Total and phosphorylated tau proteins: Evaluation as core biomarker candidates in frontotemporal dementia [PDF]

, 2004
An ever increasing number of patients with neurodegenerative disorders calls for the evaluation of potential diagnostic markers that allow an early diagnosis and an early initiation of specific therapy. Clinical diagnosis of Alzheimer's disease (AD), the
Teipel, S. J., Hampel, H., Harald Hampel, Stefan J. Teipel   +3 more
core   +1 more source

Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: Marker candidates for dementia with Lewy bodies [PDF]

, 2007
Background: The measurement of biomarkers in cerebrospinal fluid (CSF) has gained increasing acceptance in establishing the diagnosis of some neurodegenerative diseases.
Steinacker, Petra, Brechlin, Peter, Bahn, Erik, Bibl, Mirko, Locascio, Joseph J., Kretzschmar, Hans A., Mollenhauer, Brit, Trenkwalder, Claudia, Schlossmacher, Michael G., Poser, Sigrid, Otto, Markus, Wiltfang, Jens   +11 more
core   +1 more source

The Molecular Chaperone Artemin Efficiently Blocks Fibrillization of TAU Protein In Vitro

Cell Journal, 2017
Objective: Aggregation of the TAU proteins in the form of neurofibrillary tangles (NFTs) in the brain is a common risk factor in tauopathies including Alzheimer’s disease (AD).
Zahra Khosravi, Mohammad Ali Nasiri Khalili, Sharif Moradi, Reza Hassan Sajedi, Mehdi Zeinoddini   +4 more
doaj   +1 more source

Folding of the Tau Protein on Microtubules

Angewandte Chemie International Edition, 2015
Abstract Microtubules are regulated by microtubule‐associated proteins. However, little is known about the structure of microtubule‐associated proteins in complex with microtubules. Herein we show that the microtubule‐associated protein Tau, which is intrinsically disordered in solution, locally folds into a stable structure upon ...
Kadavath, H., Jaremko, M., Jaremko, L., Biernat, J., Mandelkow, E., Zweckstetter, M.   +5 more
openaire   +6 more sources

Analytical performance and clinical utility of the INNOTEST (R) PHOSPHO-TAU(181P) assay for discrimination between Alzheimer's disease and dementia with Lewy bodies [PDF]

, 2006
Background: Total tau (T-tau) and beta-amyloid((1-42)) (A beta(1-42)) levels in cerebrospinal fluid (CSF) can differentiate Alzheimer's disease (AD) from normal aging or depressive pseudo-dementia.
Bläser, Miriam, Blennow, Kaj,, Vanderstichele, Hugo, Bürger, Katharina, Karen De Vreese, Anari, Lessia, Olsson, Annika Ohrfelt, Miriam Bläser, OLSSON AO, BLASER M, Eugeen Vanmechelen, Harald Hampel, DiLuca, Monica, BURGER K, ANDREASEN N, Christian Sindic, Niels Andreasen, Vanmechelen, Eugeen, Frank Hulstaert, PARNETTI L, LANARI A, VANDERSTICHELE H, Andreasen, Niels, DILUCA M, Katharina Bürger, Pottel, Hans, Öhrfelt Olsson, Annika,, Lanari, Alessia, Parnetti, Lucilla, DE VREESE K, Sindic, Christian, Hulstaert, Frank, Buerger, Katharina, PADOVANI, Alessandro, Monica DiLuca, De Vreese, Karen, Kaj Blennow, Ivanoiu, Adrian, POTTEL H, Padovani, Allesandro, BLENNOW K, Lucilla Parnetti, Annika Ohrfelt Olsson, Hans Pottel, HAMPEL H, Alessia Lanari, Allesandro Padovani, Hampel, Harald, Hugo Vanderstichele, SINDIC C, IVANOIU A, VANMECHELEN E., Blennow, Kaj, HULSTAERT F, Adrian Ivanoiu   +54 more
core   +1 more source

Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates

Frontiers in Immunology, 2023
Single-domain antibodies, also known as nanobodies, are broadly important for studying the structure and conformational states of several classes of proteins, including membrane proteins, enzymes, and amyloidogenic proteins.
Jennifer M. Zupancic, Jennifer M. Zupancic, Matthew D. Smith, Matthew D. Smith, Hanna Trzeciakiewicz, Mary E. Skinner, Sean P. Ferris, Emily K. Makowski, Emily K. Makowski, Michael J. Lucas, Michael J. Lucas, Michael J. Lucas, Nikki McArthur, Ravi S. Kane, Henry L. Paulson, Henry L. Paulson, Henry L. Paulson, Peter M. Tessier, Peter M. Tessier, Peter M. Tessier, Peter M. Tessier, Peter M. Tessier, Peter M. Tessier   +22 more
doaj   +1 more source

Distinct tau fibril types and their role in prion diseases [PDF]

, 2023
Neurodegenerative diseases are often characterized by the co-deposition of different amyloidogenic proteins, normally defining distinct proteinopathies.
CELAURO, LUIGI
core  

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

Cell Reports, 2016
Summary: Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau interacts with the RNA-binding protein (RBP) TIA1 in brain tissue, and we present the ...
Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin   +15 more
doaj   +1 more source

The regulatory effect of Tau protein on polymerization of MCF7 microtubules in vitro

Biochemistry and Biophysics Reports, 2019
Growing evidence continues to point toward the critical role of beta tubulin isotypes in regulating some intracellular functions. Changes that were observed in the microtubules’ intrinsic dynamics, the way they interact with some chemotherapeutic agents,
Mitra Shojania Feizabadi, Marcos A.V. Hernandez, Jane B. Breslin, Ibukunoluwa I. Akintola   +3 more
doaj   +1 more source

Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies

Frontiers in Neuroscience, 2020
Tauopathies are the most common type of neurodegenerative proteinopathy, being characterized by cytoplasmic aggregates of hyperphosphorylated tau protein. The formation and morphologies of these tau inclusions, the distribution of the lesions and related
Fuyuki Kametani, Mari Yoshida, Tomoyasu Matsubara, Shigeo Murayama, Yuko Saito, Ito Kawakami, Mitsumoto Onaya, Hidetomo Tanaka, Akiyoshi Kakita, Andrew C. Robinson, David M. A. Mann, Masato Hasegawa   +11 more
doaj   +1 more source