Results 31 to 40 of about 110,474 (301)
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Eales, Katherine L. +1 more
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Alzheimer disease pathology and the cerebrospinal fluid proteome
Alzheimer’s Research & Therapy, 2018 Background Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and tau-related neurodegeneration have ...
Loïc Dayon +11 more
doaj +1 more source
Characterization of amyloid-ß and other proteins related to Alzheimer's disease, their role in neurodegeneration and biomarker discovery [PDF]
, 2006 Studies were performed to identify factors explaining the difference in the neurodegeneration seen in Alzheimer’s disease (AD) and in transgenic mice.
Güntert, Andreas
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An Update on Blood-Based Markers of Alzheimer’s Disease Using the SiMoA Platform
Neurology and Therapy, 2019 The development of blood-based biomarkers of Alzheimer’s disease (AD) pathology as tools for screening the general population, and as the first step in a multistep process to determine which non-demented individuals are at greatest risk of developing AD ...
Danni Li, Michelle M. Mielke
doaj +1 more source
Genetic association of CDC2 with cerebrospinal fluid tau in Alzheimer's disease [PDF]
, 2005 We have recently reported that a polymorphism in the cell division cycle (CDC2) gene, designated Ex6 + 7I/D, is associated with Alzheimer's disease (AD). The CDC2 gene is located on chromosome 10q21.1 close to the marker D10S1225 linked to AD.
Prince, J. A. +23 more
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Differences Between Human and Murine Tau at the N-terminal End
Frontiers in Aging Neuroscience, 2020 Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the ...
Félix Hernández +6 more
doaj +1 more source
Tau Protein and Neurodegeneration
Alzheimer's & Dementia, 2004 Abstract Background In 1988, we showed that tau protein is an integral component of the paired helical filaments (PHFs) of Alzheimer's disease. Over thirty neurodegenerative diseases are now known to exhibit filamentous tau inclusions. We identified the six tau isoforms that are produced in the
openaire +3 more sources
Histological markers in nasal mucosa of patients with Alzheimer's disease [PDF]
, 1998 Neuropathological changes such as dystrophic neurites and the presence of abnormal tau protein in the olfactory system, including primary sensory cells and nerve fibres have previously been demonstrated in nasal mucosa tissue of patients with Alzheimer's
Müller-Spahn, Franz +7 more
core +1 more source
DnaJC7 specifically regulates tau seeding
eLife, 2023 Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate.
Valerie Ann Perez +7 more
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Tau Protein: Function and Pathology [PDF]
International Journal of Alzheimer's Disease, 2012 In the last decade, the fundamental role of the microtubule-associated protein tau in neurodegeneration and dementia has been widely accepted. The generation of various transgenic models for tau pathology, varying in expressed mutations and driving promoters with either permanent (constitutive) or inducible expression, as well as the use of alternative
Rosenmann, Hanna +3 more
openaire +2 more sources