Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease
, 2010 Hyperphosphorylation of the microtubule-associated protein tau is a significant determinant in AD (Alzheimer's disease), where it is associated with disrupted axonal transport and probably causes synaptic dysfunction.
Perry, V. Hugh +2 more
core +1 more source
Deletion of endogenous Tau proteins is not detrimental in Drosophila. [PDF]
Sci Rep, 2016 Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble paired helical filaments is involved in the pathogenesis of Alzheimer's disease (AD ...
Burnouf S +9 more
europepmc +2 more sources
Deregulation of oxidative phosphorylation system and energy homeostasis in Alzheimer's disease [PDF]
, 2009 Alzheimer’s disease (AD) is the most frequent form of dementia among the elderly affecting dozens of million people worldwide. Post-mortem, the disease is characterized by two main neuropathological hallmarks: extracellular amyloid plaques and ...
Rhein, Virginie
core +1 more source
Improved Expression of Aggregation-Prone Tau Proteins Using a Spidroin-Derived Solubility Tag
SeparationsTauopathies, a group of neurodegenerative disorders, are characterized by the abnormal aggregation of microtubule-associated Tau proteins in neurons and glial cells.
Kevin Muwonge +5 more
doaj +1 more source
SUMO1 modification of 0N4R-tau is regulated by PIASx, SENP1, SENP2, and TRIM11
Biochemistry and Biophysics ReportsTau is a microtubule-associated protein that contributes to cytoskeletal stabilization. Aggregation of tau proteins is associated with neurodegenerative disorders such as Alzheimer's disease.
Harmony Wada +2 more
doaj +1 more source
Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. [PDF]
PLoS ONE, 2012 Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD). The aggregation of hyperphosphorylated tau into neurofibrillary tangles is also a hallmark brain lesion of AD.
Yang Yu +12 more
doaj +1 more source
Proteasomal degradation of tau protein [PDF]
Journal of Neurochemistry, 2002 AbstractFilamentous inclusions composed of the microtubule‐associated protein tau are a defining characteristic of a large number of neurodegenerative diseases. Here we show that tau degradation in stably transfected and non‐transfected SH‐SY5Y cells is blocked by the irreversible proteasome inhibitor lactacystin.
Della C, David +5 more
openaire +2 more sources
The Calcium-Binding Protein EFhd2 Modulates Synapse Formation In Vitro and Is Linked to Human Dementia [PDF]
, 2014 EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal dementia.
Gunn-Moore, Frank J +7 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
ALZHEIMER'S DISEASE AND TAU PROTEINS
The Lancet, 1986 info:eu-repo/semantics ...
Brion, Jean Pierre +2 more
openaire +3 more sources