Results 41 to 50 of about 1,790,741 (301)
Tau Protein and Neurodegeneration
Alzheimer's & Dementia, 2004 Abstract Background In 1988, we showed that tau protein is an integral component of the paired helical filaments (PHFs) of Alzheimer's disease. Over thirty neurodegenerative diseases are now known to exhibit filamentous tau inclusions. We identified the six tau isoforms that are produced in the openaire +3 more sourcesCerebrospinal Fluid Tau, p-Tau 181 and Amyloid-beta(38/40/42) in Frontotemporal Dementias and Primary Progressive Aphasias [PDF]
, 2010 Background/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-beta(A beta)(1-38), A beta(1-40), A beta(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25 ...Hermann Esselmann, Mirko Bibl, Johannes Kornhuber, Markus Otto, Esselmann, Hermann, Rüther, Eckart, Otto, Markus, Lewczuk, Piotr, Kornhuber, Johannes, Eckart Rüther, Piotr Lewczuk, Brit Mollenhauer, Bibl, Mirko, Wolf, Stefanie, Jens Wiltfang, Mollenhauer, Brit, Wiltfang, Jens, Stefanie Wolf, Esselmann, Hermann; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany, Wiltfang, Jens; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany, Mollenhauer, Brit; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany, Bibl, Mirko; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany, Rüther, Eckart; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany, Rüther, Echart, Wolf, Stefanie; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany, Lewczuk, Piotr; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany, Otto, Markus; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany, Kornhuber, Johannes; aDepartment of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, and bKlinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen, Essen, cUniversity of Göttingen and Paracelsus-Elena Klinik, Kassel, dDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, eDepartment of Psychiatry, University of Göttingen, Göttingen, fInstitute for Neurology, University of Ulm, Ulm, and gDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University of Munich, Munich, Germany +27 morecore +1 more sourceHistological markers in nasal mucosa of patients with Alzheimer's disease [PDF]
, 1998 Neuropathological changes such as dystrophic neurites and the presence of abnormal tau protein in the olfactory system, including primary sensory cells and nerve fibres have previously been demonstrated in nasal mucosa tissue of patients with Alzheimer's Müller-Spahn, Franz, Mandelkow, Eva-Maria, Golombowski, Sidonie, Peschel, Oliver, Unger, Jürgen, Hock, Christoph, Probst, Alphonse, Riederer, Andreas +7 morecore +1 more sourceDnaJC7 specifically regulates tau seeding
eLife, 2023 Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate.Valerie Ann Perez, David W Sanders, Ayde Mendoza-Oliva, Barbara Elena Stopschinski, Vishruth Mullapudi, Charles L White, Lukasz A Joachimiak, Marc I Diamond +7 moredoaj +1 more sourceStructural characterization of intrinsically disordered proteins by NMR spectroscopy. [PDF]
, 2013 Recent advances in NMR methodology and techniques allow the structural investigation of biomolecules of increasing size with atomic resolution. NMR spectroscopy is especially well-suited for the study of intrinsically disordered proteins (IDPs) and ...Contreras-Martos, Sara, Peter Tompa, Cedeno, Cesyen, Simone Kosol, Kosol, Simone, Tompa, Péter, Sara Contreras-Martos, Cesyen Cedeño +7 morecore +1 more sourceMAPping out distribution routes for kinesin couriers [PDF]
, 2013 In the crowded environment of eukaryotic cells, diffusion is an inefficient distribution mechanism for cellular components. Long-distance active transport is required and is performed by molecular motors including kinesins.Moores, Carolyn A., Houdusse, A., Atherton, Joseph, Joseph Atherton, Carolyn Moores, Anne Houdusse +5 morecore +1 more source
