Results 51 to 60 of about 1,790,741 (301)

Tau Protein: Function and Pathology [PDF]

International Journal of Alzheimer's Disease, 2012
In the last decade, the fundamental role of the microtubule-associated protein tau in neurodegeneration and dementia has been widely accepted. The generation of various transgenic models for tau pathology, varying in expressed mutations and driving promoters with either permanent (constitutive) or inducible expression, as well as the use of alternative
Rosenmann, Hanna, Blum, David, Kayed, Rakez, Ittner, Lars M.   +3 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Deregulation of oxidative phosphorylation system and energy homeostasis in Alzheimer's disease [PDF]

, 2009
Alzheimer’s disease (AD) is the most frequent form of dementia among the elderly affecting dozens of million people worldwide. Post-mortem, the disease is characterized by two main neuropathological hallmarks: extracellular amyloid plaques and ...
Rhein, Virginie
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Tau protein, A beta 42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies [PDF]

, 2005
The intra vitam diagnosis of dementia with Lewy bodies (DLB) is still based on clinical grounds. So far no technical investigations have been available to support this diagnosis.
Cepek, L., Neumann, M., Ciesielczyk, Barbara, Cepek, Lukas, Neumann, Manuela, Trenkwalder, C., Kretzschmar, Hans A., Otto, M., Mollenhauer, B., Schulz-Schaeffer, W. J., Poser, Sigrid, Otto, Markus, Ciesielczyk, B., Steinacker, Petra, Steinacker, P., Wiltfang, J., Schulz-Schaeffer, Walter J., Poser, S., Bibl, Mirko, Mollenhauer, Brit, Trenkwalder, Claudia, Bibl, M., Wiltfang, Jens, Kretzschmar, H. A.   +23 more
core   +1 more source

Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. [PDF]

PLoS ONE, 2012
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD). The aggregation of hyperphosphorylated tau into neurofibrillary tangles is also a hallmark brain lesion of AD.
Yang Yu, Lan Zhang, Xiaojing Li, Xiaoqin Run, Zhihou Liang, Yi Li, Ying Liu, Moon H Lee, Inge Grundke-Iqbal, Khalid Iqbal, David J Vocadlo, Fei Liu, Cheng-Xin Gong   +12 more
doaj   +1 more source

ALZHEIMER'S DISEASE AND TAU PROTEINS

The Lancet, 1986
info:eu-repo/semantics ...
Brion, Jean Pierre, Flament Durand, Jacqueline, Dustin, Pierre   +2 more
openaire   +3 more sources

Proteasomal degradation of tau protein [PDF]

Journal of Neurochemistry, 2002
AbstractFilamentous inclusions composed of the microtubule‐associated protein tau are a defining characteristic of a large number of neurodegenerative diseases. Here we show that tau degradation in stably transfected and non‐transfected SH‐SY5Y cells is blocked by the irreversible proteasome inhibitor lactacystin.
Della C, David, Robert, Layfield, Louise, Serpell, Yolanda, Narain, Michel, Goedert, Maria Grazia, Spillantini   +5 more
openaire   +2 more sources

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source