Results 11 to 20 of about 176,754 (305)

ALZHEIMER'S DISEASE AND TAU PROTEINS

The Lancet, 1986
info:eu-repo/semantics ...
Brion, Jean Pierre, Flament Durand, Jacqueline, Dustin, Pierre   +2 more
openaire   +5 more sources

Amyloidogenesis of Tau protein [PDF]

Protein Science, 2017
AbstractThe role of microtubule‐associated protein Tau in neurodegeneration has been extensively investigated since the discovery of Tau amyloid aggregates in the brains of patients with Alzheimer's disease (AD). The process of formation of amyloid fibrils is known as amyloidogenesis and attracts much attention as a potential target in the prevention ...
Bartosz Nizynski, Wojciech Dzwolak, Krzysztof Nieznanski   +2 more
openaire   +2 more sources

Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks

Frontiers in Aging Neuroscience, 2022
Background and objectiveBlood-based biomarkers represent a promising approach to help identify early Alzheimer’s disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for potential ...
Yuting Zhang, Upamanyu Ghose, Noel J. Buckley, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Kristel Sleegers, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleó, Julius Popp, Julius Popp, Pablo Martinez-Lage, Cristina Legido-Quigley, Cristina Legido-Quigley, Frederik Barkhof, Frederik Barkhof, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Pieter Jelle Visser, Pieter Jelle Visser, Lars Bertram, Lars Bertram, Simon Lovestone, Simon Lovestone, Alejo J. Nevado-Holgado, Liu Shi   +30 more
doaj   +1 more source

RNA binding proteins co-localize with small tau inclusions in tauopathy

Acta Neuropathologica Communications, 2018
The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer’s disease (AD).
Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F. Abisambra, Hu Li, Benjamin Wolozin   +11 more
doaj   +1 more source

Fibril-forming motifs are essential and sufficient for the fibrillization of human Tau. [PDF]

PLoS ONE, 2012
BACKGROUND: The misfolding of amyloidogenic proteins including human Tau protein, human prion protein, and human α-synuclein is involved in neurodegenerative diseases such as Alzheimer disease, prion disease, and Parkinson disease.
Sheng-Rong Meng, Ying-Zhu Zhu, Tong Guo, Xiao-Ling Liu, Jie Chen, Yi Liang   +5 more
doaj   +1 more source

Nuclear tau and its potential role in Alzheimer’s disease [PDF]

, 2016
Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra, Bukar Maina, Mahmoud, Serpell, Louise   +2 more
core   +2 more sources

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis

Frontiers in Aging Neuroscience, 2017
Microtubule-associated protein tau is hyperphosphorylated and aggregated in affected neurons in Alzheimer disease (AD) brains. The tau pathology starts from the entorhinal cortex (EC), spreads to the hippocampus and frontal and temporal cortices, and ...
Wen Hu, Wen Hu, Feng Wu, Yanchong Zhang, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Liu, Fei Liu   +8 more
doaj   +1 more source

Tau Proteins and Tauopathies in Alzheimer's Disease. [PDF]

Cell Mol Neurobiol, 2018
Chong FP, Ng KY, Koh RY, Chye SM.
europepmc   +2 more sources

EFhd2 Affects Tau Liquid–Liquid Phase Separation

Frontiers in Neuroscience, 2019
The transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in Alzheimer’s disease and related dementias, is poorly understood.
Irving E. Vega, Irving E. Vega, Irving E. Vega, Andrew Umstead, Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan   +6 more
doaj   +1 more source

Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities [PDF]

, 2011
Alzheimer\u27s disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins.
Brody, David L, Holtzman, David M, LaFerla, Frank M, Tran, Hien T   +3 more
core   +2 more sources