Results 111 to 120 of about 18,473 (221)

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies

Tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or phosphorylation and aggregation of the microtubule-associated protein TAU, encoded by the gene MAPT. Neuronal
Zempel, Hans, Wunderlich, Gilbert, Langerscheidt, Felix, Wied, Tamara, Eimeren, Thilo van, van Eimeren, Thilo, Al Kabbani, Mohamed Aghyad   +6 more
core   +1 more source

Disease-modifying therapies for tauopathies: agents in the pipeline

, 2019
Introduction: Tauopathies are heterogeneous clinicopathological entities characterized by abnormal neuronal and/or glial inclusions of the microtubule-binding protein tau.
Greco A., Daniele A.
core   +1 more source

Chronic effects of inflammation on tauopathies

, 2023
Tauopathies are a heterogeneous group of neurodegenerative disorders that are characterised by the aggregation of the microtubule-associated protein tau into filamentous inclusions within neurons and glia.
Langworth-Green, C, Lees, A, Zandi, M, Thom, M, Patel, S, Jaunmuktane, Z, Hardy, J, Jabbari, E, Morris, H, Duff, K   +9 more
core  

Arginine metabolism and tauopathies

, 2019
Tauopathies refers to a group of neurodegenerative diseases characterized by the intracellular accumulation of hyperphosphorylated tau protein.
Vemula, Pranav Kumar
core  

TAU PROTEIN AND HUMAN TAUOPATHIES: AN OVERWIEV* [PDF]

, 2008
The growing knowledge of the molecular mechanisms of neurodegenerative diseases isunveiling their common characteristics, enabling their classification according to the pathologically changed protein that aggregates in the diseased central nervous system.
Mara Bresjanac, Nina Mohorko
core  

ANXA2 Protein and Its Role in Neurodegeneration Processes

Life
ANXA2 is a multifunctional member of the annexin protein family, implicated in vesicular transport, antioxidant defense, and actin remodeling. Its role in oncogenesis is actively investigated, notably in glioblastoma, astrocytoma, and breast cancer ...
Suzanna A. Partevian, Petr A. Slominsky, Maria I. Shadrina, Anelya Kh. Alieva   +3 more
doaj   +1 more source

Molecular signatures distinguishing tauopathies

Alzheimer’s disease and primary tauopathies are neurodegenerative disorders involving the aggregation of different isoforms of the tau protein (named either 4R or 3R).
Kyalu Ngoie Zola, Nathalie
core  

The Tauopathies [PDF]

The American Journal of Pathology, 1999
Michel Goedert, Masato Hasegawa
openaire   +1 more source

Astrogliopathy in tauopathies

Astrocytes are involved in many diseases of the central nervous system, not only as reactive cells to neuronal damage but also as primary actors in the pathological process.
Ferrer, Isidro (Ferrer Abizanda)
core   +1 more source