Results 111 to 120 of about 1,190 (173)

Diagnostic Performance of the AlzoSure Predict Assay and Its Association With Alzheimer's Disease Biomarkers and Imaging Findings

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Early diagnosis of Alzheimer's disease (AD) is critical for improving patient outcomes. The laboratory‐developed blood test of AlzoSure measures the unfolded conformational variant of p53 (U‐p53AZ) in plasma and has shown promise as a screening tool for AD risk.
Ali Rajabpour‐Sanati, Hamide Nasiri, Farbod Khosravi, Farhang Ghahrieh, Alireza Asemanrafat, Alireza Keshavarz Bahaqiqat, Parsa Saberian, Rozhin Bakhshi, Faranak Rastegari, Ramin Ahangar‐Sirous, Amirmohammad Shahidzadehasadi, Hadis Seif, Maryam Ghahremani, Faeze Gandomi‐Nasrabadi, Zahra Azizan, Mahsa Mayeli, for the Alzheimer's Disease Neuroimaging Initiative*   +16 more
wiley   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm, Volume 7, Issue 8, August 2026.
The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
wiley   +1 more source

Voice and Speech in Atypical Parkinsonian Disorders

Movement Disorders Clinical Practice, Volume 13, Issue 8, Page 1848-1860, August 2026.
Background Motor speech disorders are early, common, and functionally limiting features of atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA). These impairments are underrecognized and undertreated in neurology clinics.
Federico Rodriguez‐Porcel, Farwa Ali, Michiko Bruno, Heather Davis Cuevas, Rohit Dhall, Kylie Dunne‐Platero, Lawrence I. Golbe, Ihtsham Haq, Nicole Herndon, Lawrence S. Honig, Kyurim Kang, Sarah Kremen, Guillaume Lamotte, Nikolaus R. McFarland, Michela Mir, Leila Montaser‐Kouhsari, Alexander Pantelyat, Joel Page, Hylan Pickett, Laura Purcell Verdun, Kelly Richardson, Jessica Shurer, Michelle Troche, Rene L. Utianski, Katya Villarreal‐Cavazos, Tuhin Virmani, Anne‐Marie Wills, as the Diagnosis and Treatment Working Group, CurePSP Center of Care (CoC) Network, Farwa Ali, Michiko Bruno, Timothy Chang, Rohit Dhall, Kimiko Domoto‐Reilly, Lawrence I. Golbe, Ihtsham Haq, Lawrence S. Honig, Sarah Kremen, Guillaume Lamotte, Zoltan Mari, Nikolaus R. McFarland, Leila Montaser‐Kouhsari, Alexander Pantelyat, Federico Rodriguez‐Porcel, Junaid Siddiqui, Jessica Shurer, Christopher Spears, Tuhin Virmani, Anne‐Marie Wills   +48 more
wiley   +1 more source

Distinct Transposable Element Transcript Patterns in Microglia Across Aging and Alzheimer's Disease

Aging Cell, Volume 25, Issue 8, August 2026.
Microglia‐specific transposable element patterns across human aging, Alzheimer's disease, mouse models of Alzheimer's disease pathology, and in vitro experiments. ABSTRACT Microglia, the brain's resident immune cells, are transcriptionally diverse and highly dynamic, but during aging and disease they lose their transcriptomic flexibility and adopt a ...
Randy A. Grant, Rachel L. Doser, Thomas J. LaRocca   +2 more
wiley   +1 more source

Water‐Mediated Phosphoryl Wires Stabilize Pathological Tau Fibrils

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
Extended 1D phosphoryl “wires” stabilize in‐register amyloid tau fibrils, as demonstrated by multiple‐quantum spin‐counting NMR, TEM, and MD simulations, using fibrils of tau peptide jR2R3‐P301L (tau295–313) with phosphorylation at S305 or Y310. ABSTRACT Hyperphosphorylation of tau is a hallmark of tauopathies, with specific phosphorylation sites ...
Lokeswara Rao Potnuru, Austin DuBose, Fiona Mon, Mesopotamia S. Nowotarski, Michael Vigers, Boqin Zhang, Chung‐Ta Han, John E. Straub, Songi Han   +8 more
wiley   +2 more sources

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source

Gait Impairment and Alzheimer's Disease Pathology: A Narrative Review on Mechanistic Links

Geriatrics &Gerontology International, Volume 26, Issue 8, August 2026.
Gait impairment and AD‐related pathology may be linked through shared risks, preclinical AD changes, feedback effects of persistent gait dysfunction, and life‐course susceptibility, underscoring the importance of maintaining brain–body health across the lifespan. ABSTRACT In older adults, gait has emerged as an important indicator of overall health and
Ryota Sakurai, Manuel Montero‐Odasso
wiley   +1 more source

Microtubules in Spinal Cord Injury: From Cytoskeletal Dysregulation to Therapeutic Regeneration

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
Graphical illustration of the microtubule interactome following spinal cord injury as potential targets for therapy. ABSTRACT Spinal cord injury (SCI) triggers an immediate and sustained disruption of the composition and organization of the neuronal cytoskeleton.
Itzhak Fischer, Peter W. Baas
wiley   +1 more source

Structural Heterogeneity of TDP‐43 Fragments in Alzheimer's Disease and Primary Age‐Related Tauopathy by Artificial Intelligence (AI)–Based 3D Segmentation

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
Immunostaining of anti‐phosphorylated TDP‐43 (pTDP‐43), TDP‐43 C‐terminal fragment (TDP‐43 C) and TDP‐43 N‐terminal fragment (TDP‐N), combined with an AI‐based object recognition, reconstruction and automatic 3D morphometric analysis pipeline in limbic regions revealed that distinct TDP‐43 fragment aggregation patterns, underscoring region‐specific ...
Gokhan Uruk, Rodolfo G. Gatto, Nadia Hossain, Jennifer L. Whitwell, R. Ross Reichard, Keith A. Josephs   +5 more
wiley   +1 more source

Attenuation of Tau Hyperphosphorylation by Chronic Toxoplasma gondii Infection in a Mouse Model of Alzheimer's Disease

Parasite Immunology, Volume 48, Issue 8, August 2026.
ABSTRACT Alzheimer's disease (AD) is characterized by amyloid‐β (Aβ) peptide accumulation and tau protein‐mediated neurodegeneration, and neuroinflammation is increasingly recognized as a major process associated with tau pathology. Chronic Toxoplasma gondii infection reduces amyloid accumulation in AD models through immune modulation, but its stage ...
Seung‐Hwan Seo, Ji‐Eun Lee, Eun‐Ji Cho, Eun‐Hee Shin   +3 more
wiley   +1 more source