Results 131 to 140 of about 1,190 (173)
Some of the next articles are maybe not open access.
Neurology India, 2007
Tau protein is a neuronal microtubule-associated protein (MAP), which localizes primarily in the axon. It is one of the major and most widely distributed MAPs in the central nervous system. Its biochemistry and molecular pathology is being increasingly studied. Tau is a key component of neurofbrillary tangles in Alzheimer's disease (AD). Disorders with
Mathuranath, PS, Robert, M
openaire +2 more sources
Tau protein is a neuronal microtubule-associated protein (MAP), which localizes primarily in the axon. It is one of the major and most widely distributed MAPs in the central nervous system. Its biochemistry and molecular pathology is being increasingly studied. Tau is a key component of neurofbrillary tangles in Alzheimer's disease (AD). Disorders with
Mathuranath, PS, Robert, M
openaire +2 more sources
Pathogenesis of the Tauopathies
Journal of Molecular Neuroscience, 2011Microtubule-associated protein tau is the most commonly misfolded protein in human neurodegenerative diseases, where it becomes hyperphosphorylated and filamentous. Mutations in MAPT, the tau gene, cause approximately 5% of cases of frontotemporal dementia. They are frequently accompanied by parkinsonism. The existence of MAPT mutations has established
Michel, Goedert +1 more
openaire +2 more sources
Molecular Pathogenesis of the Tauopathies
Annual Review of Pathology: Mechanisms of Disease, 2019The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia as their common denominator. In this review, we describe the biochemical and histological differences in Tau pathology that are characteristic of the spectrum of frontotemporal lobar degeneration as primary tauopathies and of Alzheimer's disease as a secondary ...
Götz, Jürgen +2 more
openaire +5 more sources
Neuropathology, 2006
In this symposium, cutting‐edge data on neuropathology, pathological biochemistry and molecular biology of sporadic and familial tauopathies, as well as on the development of model animals, were presented and discussed by five expert neuropathologists.
openaire +2 more sources
In this symposium, cutting‐edge data on neuropathology, pathological biochemistry and molecular biology of sporadic and familial tauopathies, as well as on the development of model animals, were presented and discussed by five expert neuropathologists.
openaire +2 more sources
2014
Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The spectrum of tau pathologies expands beyond the traditionally discussed disease forms like Pick disease, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. Emerging entities and pathologies include
openaire +2 more sources
Tauopathies are neurodegenerative disorders characterized by the deposition of abnormal tau protein in the brain. The spectrum of tau pathologies expands beyond the traditionally discussed disease forms like Pick disease, progressive supranuclear palsy, corticobasal degeneration, and argyrophilic grain disease. Emerging entities and pathologies include
openaire +2 more sources
Clinicopathological features of the tauopathies
Biochemical Society Transactions, 2005Developments in molecular neuropathology have led to protein-based classification systems for neurodegenerative disorders. Key proteins include α-synuclein, amyloid and tau. Alternative mRNA splicing and post-translational change, induced by a bewildering variety of protein modifying processes such as phosphorylation and ubiquitination, have generated ...
B, Murray, T, Lynch, M, Farrell
openaire +2 more sources
Imaging biomarkers in tauopathies
Parkinsonism & Related Disorders, 2016Abnormally aggregated tau protein is central to the pathophysiology of Alzheimer's disease, frontotemporal dementia variants, progressive supranuclear palsy, corticobasal degeneration and chronic traumatic encephalopathy. The post-mortem cortical density of hyperphosphorylated tau tangles correlates with pre-morbid cognitive dysfunction and neuron loss.
Dani, Melanie +2 more
openaire +2 more sources
Anatamopathological spectrum of tauopathies
Movement Disorders, 2003The presence of tau-positive intraneuronal filamentous inclusions with or without additional inclusions in glial cells has been recognised as a major neuropathological feature in a significant group of neurodegenerative diseases, which are described as tauopathies.
Tamas, Revesz, Janice L, Holton
openaire +2 more sources
Treatment Options for Tauopathies
Current Treatment Options in Neurology, 2012To date, there are no approved and established pharmacologic treatment options for tauopathies, a very heterogenous group of neuropsychiatric diseases often leading to dementia and clinically diagnosed as atypical Parkinson syndromes. Among these so-called Parkinson plus syndromes are progressive supranuclear palsy (PSP), also referred to as Steele ...
Tarik, Karakaya +3 more
openaire +2 more sources
Neuropathology, 2006
Intracellular fibrillar amyloid lesions comprised of tau proteins are pathological hallmarks in diverse neurodegenerative disorders. As models of these tauopathies, transgenic mice overexpressing tau with or without mutations discovered in familial tauopathies were generated.
Makoto, Higuchi +2 more
openaire +2 more sources
Intracellular fibrillar amyloid lesions comprised of tau proteins are pathological hallmarks in diverse neurodegenerative disorders. As models of these tauopathies, transgenic mice overexpressing tau with or without mutations discovered in familial tauopathies were generated.
Makoto, Higuchi +2 more
openaire +2 more sources